BS University of Paris XII, Paris, France MS University of Paris XII, Paris, France PhD Pasteur Institute, Paris, France

Recombinant antibody, phage display, protein engineering, cell-based assay development and hematopoietic stem cells

Emadi, S., Liu, R., Yuan, B., Schulz, P., Chad, M., Lyubchenko, Y., Messer, A., and Sierks, MR.,“Inhibiting aggregation of α-synuclein with human single chain antibody fragments,” Biochemistry, 43, 2871-2878, 2004. Emadi, S., Clay, D., Desterke, C., Guerton, B., Maquarre, E., Charpentier, A., Jasmin, C. and Le Bousse-Kerdilès, MC., “Il8 and its CXCR-1 and CXCR-2 receptors participate in the control of megakaryocytic proliferation, differentiation and ploidy in myeloid metaplasia with myelofibrosis,” Blood, 105 (2), 464-73, 2005. Emadi, S., Barkhordarian, H., Wang, MS., Schulz, P., and Sierks, MR., “Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity,” Journal of Molecular Biology, 364 (4), 1132-1144, 2007. Emadi, S., Kasturiangan, S., Wang, MS., Schultz, P., and Sierks, MR., “Detecting morphologically distinct oligomeric forms of α-synuclien,” The Journal of Biological Chemistry, 24; 284 (17), 11048-11058, 2009. Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E, “ESCRT mediated uptake and degradation of brain targeted α-synuclein-single chain antibody attenuates neuronal degeneration in vivo”Molecular Therapy, 2014.