Education PhD in Chemistry, UCLA 2013 BS in Chemistry, Nanjing University, 2008 Awards NIH/NIGMS MIRA Award NIH/NIBIB Trailblazer Award Omnibus Research and Travel Award, UCR Featured Young Investigators in Analytical nd Bioanalytical Science, Analytical and Bioanalytical Chemistry

Single-Cell Analysis Bioorganic Chemistry and Chemical Biology Fluorescence Spectroscopy

INHIBITING MATRIX METALLOPROTEINASE-2 ACTIVATION BY PERTURBING PROTEIN-PROTEIN INTERACTIONS USING A CYCLIC PEPTIDE. P. Sarkar, Z. Li, W. Ren, S. Wang, S. Shao, J. Sun, X. Ren, N.G. Perkins, Z. Guo, C.-E. A. Chang, J. Song, and M. Xue, J. Med. Chem. 2020, 63, 6979-6990. doi: 10.1021/acs.jmedchem.0c00180 MULTI-OMIC SINGLE-CELL SNAPSHOTS REVEAL MULTIPLE INDEPENDENT TRAJECTORIES TO DRUG TOLERANCE IN A MELANOMA CELL LINE. Y. Su, M.E. Ko, H. Cheng, R. Zhu, M. Xue, J. Wang, J.W. Lee, L. Frankiw, A. Xu, S. Wong, L. Robert, K. Takata, D. Yuan, Y. Lu, S. Huang, A. Ribas, R. Levine, G.P. Nolan, W. Wei, S.K. Plevritis, G. Li, D. Baltimore, and J.R. Heath, Nat. Comm. 2020, 11, 2345. doi: 10.1038/s41467-020-15956-9 MONITORING THE CROSSTALK BETWEEN METHYLATION AND PHOSPHORYLATION ON HISTONE PEPTIDES WITH HOST-ASSISTED CAPILLARY ELECTROPHORESIS. J. Lee, J. Chen, P. Sarkar, M. Xue, R.J. Hooley, and W. Zhong, Anal. Bioanal. Chem. 2020, doi: 10.1007/s00216-020-02486-y SENSING OF CITRULLINE MODIFICATIONS IN HISTONE PEPTIDES BY DEEP CAVITAND HOSTS. A.D. Gill, B.L. Hickey, S. Wang, M. Xue, W. Zhong, and R.J. Hooley, Chem. Comm. 2019, 55, 13259-13262. doi: 10.1039/C9CC07002H LIQUID BIOPSY-BASED SINGLE-CELL METABOLIC PHENOTYPING OF LUNG CANCER PATIENTS FOR INFORMATIVE DIAGNOSTICS. Z. Li, Z. Wang, Y. Tang, X. Lu, J. Chen, Y. Dong, B. Wu, C. Wang, L. Yang, Z. Guo, M. Xue, S. Lu, W. Wei, and Q. Shi, Nat. Comm. 2019, 10 (1): 1856. doi: 10.1038/s41467-019-11808-3 FLUORESCENCE IMAGING-BASED METHODS FOR SINGLE-CELL PROTEIN ANALYSIS. S. Wang, F. Ji, Z. Li, and M. Xue, Anal. Bioanal. Chem. 2019, 3, 1-9. doi: 10.1007/s00216-019-01694-5 A CHEMICAL APPROACH FOR PROFILING INTRACELLULAR AKT SIGNALING DYNAMICS FROM SINGLE CELLS. S. Shao, Z. Li, H. Cheng, S. Wang, N.G. Perkins, P. Sarkar, W. Wei, and M. Xue, J. Am. Chem. Soc. 2018, 140, 13586-13589. doi: 10.1021/jacs.8b08931 CONSTRUCTION OF A SEQUENCEABLE PROTEIN MIMETIC PEPTIDE LIBRARY WITH A TRUE 3D DIVERSIFIABLE CHEMICAL SPACE. Z. Li, S. Shao, X. Ren, J. Sun, Z. Guo, S. Wang, M.M. Song, C.-E.A. Chang, and M. Xue, J. Am. Chem. Soc. 2018, 140, 14552-14556. doi: 10.1021/jacs.8b08338 DESIGN OF A MULTISPHERICAL CAVITY CARBON WITH IN SITU SILICA MODIFICATIONS AND ITS SELF‐HUMIDIFICATION APPLICATION ON FUEL CELL ANODE SUPPORT. J. Zhang, D. Liu, S. Hou, L. Du, H. Song, S. Liao, and M. Xue, Adv. Mater. Inter. 2018, 5, 1800314. doi: 10.1002/admi.201800314 SURFACE IMMOBILIZATION OF REDOX‐LABILE FLUORESCENT PROBES: ENABLING SINGLE‐CELL CO‐PROFILING OF AEROBIC GLYCOLYSIS AND ONCOGENIC PROTEIN SIGNALING ACTIVITIES. Z. Li, H. Cheng, S. Shao, X. Lu, L. Mo, J. Tsang, P. Zeng, Z. Guo, S. Wang, D. A. Nathanson, J. R. Heath, W. Wei, M. Xue, Angew. Chem. Int. Ed. 2018, 57, 11554-11558. doi: 10.1002/anie.201803034 AN EFFICIENT CARBON CATALYST SUPPORTS WITH MESOPOROUS GRAPHENE-LIKE MORPHOLOGY. D. Liu, J. Zhang, C. Zhang, M. Lv, X. Zhang, H. Song, L. Du, and M. Xue, J. Porous Mater. 2018, 25, 913-921. doi: 10.1007/s10934-017-0503-1 SUPRAMOLECULAR ANALYTICAL CHEMISTRY IN CANCER RESEARCH. S. Shao and M. Xue, Adv. Cancer Res. 2018, 139, 147-161. doi: 10.1016/bs.acr.2018.04.005