Education: Ph.D., 2004 — University of Pittsburgh B.S., 1997 — Peking University

Professor Ye's research is focused on developing the nanoscale surface chemistry needed to manipulate and measure biomolecules and analogous systems. The nanoscale arrangements of biomolecules, such as proteins and DNA, underlie a wide spectrum of biological functions. Yet our ability to measure and control biomolecules at the nanoscale and single molecule level remains very limited. His group is using and developing sophisticated nanoscience tools to position and measure single molecules with nanometer resolution, dynamically activate the functions of individual biomolecules on surfaces, and develop artificial analogs of biological motors. The greatly improved understanding and control of biomolecules at the nanoscale have implications in unraveling key biological functions, creating artificial functional bimolecular structures, and developing ultra-sensitive biosensors.

Abel, G. R., Cao, B. H., Hein, J., Ye, T. (2014). Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry. Chemical Communications, 50, 8131-8133(Link) Shao, J., Josephs, E. A., Lee, C., Lopez, A., Ye, T. (2013) Electrochemical etching of gold within nanoshaved self-assembled monolayers. ACS Nano, 7, 5421-5429 (Link) Abel, G.R., Josephs, E. A., Luong, N., Ye, T. (2013). A switchable surface enables visualization of single DNA hybridization events with atomic force microscopy. Journal of the American Chemical Society, 135, 6399-6402(Link) Josephs, E. A., Shao, J., Ye, T. (2013). Nanografting sodium dodecyl sulfate under potential control: New insights into tip-directed molecular assembly. Nanoscale,5, 4139-4143(Link) Josephs, E. A., Ye, T. (2013). Nanoscale spatial distribution of DNA probes on model nucleic acid sensor surfaces. ACS Nano,7, 3653-3660 (Link) Josephs, E. A., Ye, T. (2012). Electric-field dependent conformations of single DNA molecules on a model biosensor surface. Nano Letters, 12, 5255-5261(Link) Lee, C., Josephs, E. A., Shao, J., Ye, T. (2012). Nanoscale chemical patterns on Au microplates. Journal of Physical Chemistry C, 116, 17625-17632. (Link) Josephs, E. A., Ye, T. (2012). A single-molecule view of conformational switching of DNA tethered to a gold electrode. Journal of the American Chemical Society, 134, 10021-10030. (Link) Hujdic, J. E., Sargisian, A. P., Shao, J., Ye, T., Menke, E. J. (2011). High-density gold nanowire arrays by lithographically patterned nanowire electrodeposition. Nanoscale, 3, 2697. (Link) Iski, E. V., El-Kouedi, M., Calderon, C., Wang, F., Bellisario, D. O., Ye, T., Sykes, E. C. H. (2010). The extraordinary stability imparted to silver monolayers by chloride. Electrochimica Acta, 56, 1652-1661. (Link) Josephs, E. A., Ye, T. (2010). Nanoscale positioning of individual DNA molecules by an atomic force microscope. Journal of the American Chemical Society, 132, 10236–10238. (This paper has been highlighted in JACS Select) Shao, J., Mirafzal, H., Petker, J. R., Cosio, J. L. S., Kelley, D. F., Ye, T. (2009). Nanoscale organization of GaSe quantum dots on a gold surface. Journal of Physical Chemistry C, 113(44), 19102–19106.(Link) Zhang, L., Kerszulis, J. A., Clark, R. J., Ye, T., Zhu, L. (2009). Catechol boronate formation and its electrochemical oxidation. Chemical Communications, 2009, 2151–2153. (Link)