Aswad, Dana W.
Professor
所属大学: University of California, Irvine
所属学院: Department of Molecular Biology and Biochemistry
邮箱:
dwaswad@uci.edu
个人主页:
http://www.faculty.uci.edu/profile.cfm?faculty_id=2135
研究领域
Regulation of protein function and gene expresssion by post-translational modification. Biochemistry of protein damage, aging, and repair. Biochemical characterization of protein pharmaceuticals.
近期论文
Juang C, Chen B, Bru JL, Nguyen K, Huynh E, Momen M, Kim J, Aswad DW. (2017) Polymorphic Variants of Human Protein L-Isoaspartyl Methyltransferase Affect Catalytic Activity, Aggregation, and Thermal Stability; Implications for the Etiology of Neurological Disorders and Cognitive Aging. J Biol Chem. 292:3656-3665. PMID: 28100787 Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJ, Aswad DW, Laird-Offringa IA. (2016) Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. J Neuroimmunol. 299:70-78. PMID: 27725125 Qin Z, Zhu JX, Aswad DW. (2016) The D-isoAsp-25 variant of histone H2B is highly enriched in active chromatin: potential role in the regulation of gene expression? Amino Acids 48(2):599-603. PMID: 26666674. Cahill L, Aswad DW. (2015) Sex Influences on the Brain: An Issue Whose Time has Come. Neuron 88(6):1084–1085. Qin Z, Dimitrijevic A, and Aswad DW (2015) Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging. Neurobiology of Aging, 36:1029-36 PMID:25465735 Dimitrijevic A, Qin Z, Aswad DW. (2014) Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse. PLoS One. 23: e100622. PMID:24955845 Qin Z, Yang J, Klassen HJ, and Aswad DW (2014) Isoaspartyl Protein Damage and Repair in Mouse Retina. Invest Ophthalmol Vis Sci. 55:1572-1579. PIMD:24550364