MNB/DYRK1a Kinase How does the Down Syndrome critical kinase, MNB/DYRK1a, regulate the microtubule cytoskeleton directly or indirectly during neuronal development and maintenance? How is MNB/DYRK1a regulated both temporally and spatially within a cell? Neuronal Cytoarchitecture How is the cytoskeleton organized and regulated in order to produce a distinct neuronal morphology? Tubulin Phosphorylation How does phosphorylation of tubulin affects its ability to polymerize into microtubules?

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