Dr. McPherson’s research group, based on the Sacramento Campus, is interested: in understanding the mechanisms underlying structural rearrangements in tumors; in bringing advanced genomic technologies to clinical application in personalized diagnosis and targeted therapeutics through maximizing the data yield from small biopsies and circulating cell free DNA; and in reducing chemotherapy-induced side effects during cancer treatment.

Tran B et al. Feasibility of Real Time Next Generation Sequencing of Cancer Genes Linked to Drug Response: Results from a Clinical Trial. Int. J. Cancer. 2012;132:1547-1555. Boutros et al. Spatial genomic heterogeneity within localized, multifocal prostate cancer. Nature Genetics. 2015;47; 736-745. Tam S, Tsao MS, McPherson JD. Optimization of miRNA-seq data preprocessing. Brief. Bioinform. 2015 Epub ahead of print. Ji J et al. Antioxidant Supplementation Reduces Genomic Alterations in human Induced Pluripotent Stem Cells. Stem Cell Reports. 2014;2: 45-51.