Signal transduction mediated through focal adhesions and their roles in tissue and disease development.

Shih YP, Sun P, Wang A, Lo SH., Tensin1 positively regulates RhoA activity through its interaction with DLC1., Biochim Biophys Acta. 2015 Sep 28;1853(12):3258-3265. Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J; PROMESA investigators, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH., Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Mvp-France, Jeunemaitre X; Leducq Transatlantic MITRAL Network., Genetic association analyses highlight biological pathways underlying mitral valve prolapse., Nat Genet. 2015 Oct;47(10):1206-11. Liao, Y. C., Chen, N. T., Shih Y. P., Dong, Y., Lo, S. H. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer cells through b-catenin. Cancer Res 2009, 69:4563- 4566. Lin, Y., Chen, N. T., Shih,Y. P., Liao, Y. C., Xue, L., and Lo, S. H, DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 2010, 29:3010-3016 Shih, Y.P., Liao, YC., Lin, Y., Lo, S. H. DLC1 negatively regulates angiogenesis in a paracrine fashion. Cancer Res 2010, 70:8270-8275. Shih Y.P., Takada, Y., Lo, S.H. Silencing of DLC1 promotes PAI-1 expression and reduces normal cell migration. Mol Cancer Res. 2012, 10:34-39. Li, J.R., Shi, L., Deng, Z., Lo, S. H., Liu, G.Y. Nanostructures of Designed Geometry and Functionality Enable Regulation of Cellular Signaling Processes. Biochemistry 2012, 51, 5876–5893 Shi L, Li, J.R., Shih, Y.P., Lo, S. H., Liu, G. Y., Nanogratings of Fibronectin Provide an Effective Biochemical Cue for Regulating Focal Adhesion and Cellular Structure. Nano Res 2012, 8): 565–575 Hong, S. Y., Shih, Y. P., Li, T., Carraway, K., Lo, S.H. CTEN Prolongs Signaling by EGFR through Reducing Its Ligand-Induced Degradation. Cancer Res. 2013, 73(16):5266-76. Lo. S.H. C-terminal tensin-like (CTEN): a promising biomarker and target for cancer. J Biochem Cell Biol. 2014, 51:150-4.