Organic synthesis, NMR, molecular modeling, biophysical characterization, molecular biology assays

The Raskatov Lab: Disease-Oriented Chemical Biology. We draw inspiration from aging-related medicinally challenging questions, which are becoming increasingly pressing as life expectancy continues to rise (the cancer/inflammation interface is of specific interest). We identify biomolecular signaling nodes that are sufficiently well-understood at the molecular level, so that a biology problem can be translated into a chemistry problem. As chemists we synthesize molecules and study their properties by means of NMR spectroscopy, crystallography and DFT computation. Molecular scaffolds that show initial promise are tested in relevant biological systems.