Ph.D. (Doctor of Philosophy)

Genomics Proteomics and Bioinformatics Molecular and Development Genetics Molecular Biology and Disease

Our main research interest is focused on understanding the molecular basis of drug (anthelmintic) resistance in parasites and in the identification of novel drug targets. We are currently interested in how nematodes metabolize drugs and the potential role of such mechanisms in drug resistance. Our research undertakes genomic and genetic approaches with both parasites and the free-living nematode Caenorhabditis elegans as a model system. The lab also has projects involving the population genetics, molecular epidemiology and molecular diagnostics of parasitic nematodes. Please visit the lab web page for further details.

Burns A, Luciani G, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, McQuibban G, Caffrey C, Cutler S, Tyers M, Giaever G, Nislow C, Fraser A, MacRae C, Gilleard JS. Roy, P (2015). Caenorhabditis elegans is a useful model for anthelmintic discovery. Nature Communications, 6:7485. doi: 10.1038/ncomms8485. Chaudhry U, Redman EM, Raman M, Gilleard ,J.S (2015) .Genetic evidence for the spread of a benzimidazole resistance mutation across southern India from a single origin in the parasitic nematode Haemonchus contortus. International Journal for Parasitology, pii: S0020-7519(15)00149-6. doi: 10.1016/j.ijpara.2015.04.007. Redman E, Whitelaw F, Tait A, Burgess C, Bartley Y, Skuce PJ, Jackson F and Gilleard JS (2015) The Emergence of Resistance to the Benzimidazole Anthelmintics in Parasitic Nematodes of Livestock is Characterised by Multiple Independent Hard and Soft Selective Sweeps. PLoS Neglected Tropical Diseases, PLoS Negl Trop Dis. 2015 Feb; 9(2): e0003494. Published online 2015 Feb 6. doi: 10.1371/journal.pntd.0003494 Laing R, Bartley D, Morrison A, Rezansoff A , Martinelli A, Laing S, Gilleard JS. (2015) The Cytochrome P450 Family in the Parasitic Nematode Haemonchus contortus. International Journal for Parasitology, 45(4):243-51.. pii: S0020-7519(14)00311-7. doi: 10.1016/j.ijpara.2014.12.001. Chaudhry U, Redman E, AbbasM, Raman M, Ashraf K and Gilleard JS. (2015) Genetic evidence for hybridization between Haemonchus contortus and Haemonchus placei in natural field populations and its implications for interspecies transmission of anthelmintic resistance. International Journal for Parasitology,45(2-3):149-59. doi:10.1016/j.ijpara.2014.09.002. Curran D, Gilleard J, Wasmuth J. (2014) Figmop: a profile HMM to identify genes and bypass troublesome gene modals in draft genomes. Bioinformatics, 15;30(22):3266-7. Gilleard JS. (2013) Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance. Parasitology, 140, issue 12, pp. 1506-1522. Laing R, Kikuchi T, Martinelli A, Tsai IJ, Beech RN, Redman E, Holroyd N, Bartley DJ, Beasley H, Britton C, Curran D, Devaney E, Gilabert A, Hunt M, Jackson F, Johnston S, Kryukov I, Li K, Morrison AA, Reid AJ, Sargison N, Saunders G, Wasmuth JD, Wolstenholme A, Berriman M, Gilleard JS*, Cotton JA* (2013) The genome and transcriptome of Haemonchus contortus: a key model parasite for drug and vaccine discovery. Genome Biology, 2013 Aug 28;14(8):R88. [Epub ahead of print] (* joint corresponding authors). Redman E, Sargison N, Morrison AA, Bartley DJ, Whitelaw F, Jackson F and Gilleard JS. (2012) Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing. PLoS Pathogens, 2012 Feb;8(2):e1002534. Epub 2012 Feb 16.