Regulation of the hypothalamo-pituitary-adrenal (HPA) axis in health and disease

Stavreva, DA, Wiench, M, John, S, Conway-Campbell, B, McKenna, M, Pooley, J, Johnson, TA, Voss, TC, Lightman, S & Hager, GL, 2009, ‘Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription’. Nature Cell Biology, vol 11., pp. 1093 - 1102 Walker, J, Terry, J & Lightman, S, 2010, ‘Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis’. Proceedings of the Royal Society B: Biological Sciences, vol 277., pp. 1627 - 1633 Conway-Campbell, B, Pooley, J, Hager, G & Lightman, S, 2012, ‘Molecular dynamics of ultradian glucocorticoid receptor action’. Mol Cell Endocrinol, vol 30;348(2)., pp. 383 - 393 Biddie, S, John, S, Sabo, P, Thurman, R, Schiltz, R, Johnson, T, Sung, M, Trump, S, Lightman, S, Vinson, C, Stamatoyannopoulos, J & Hager, G, 2011, ‘Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding’. Molecular Cell, vol 43 ., pp. 145 - 155 Conway-Campbell, B, George, C, Pooley, J, Knight, D, Norman, M, Hager, GL & Lightman, S, 2011, ‘The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its co-regulatory molecules CBP/P300 during ultradian ligand treatment’. Molecular Endocrinology, vol 25., pp. 944 - 954 Spiga, F, Waite, E, Liu, Y, Kershaw, Y, Aguilera, G & Lightman, S, 2011, ‘ACTH-Dependent Ultradian Rhythm of Corticosterone Secretion’. Endocrinology, vol 152(4)., pp. 1448 - 1457 Lightman, S & Conway-Campbell, B, 2010, ‘The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration’. Nat Rev Neurosci, vol 11., pp. 710 - 718 Sarabdjitsingh, RA, Conway-Campbell, B, Leggett, J, Waite, E, Meijer, OC, Kloet, ERd & Lightman, S, 2010, ‘Stress responsiveness varies over the ultradian glucocorticoid cycle in a brain-region-specific manner’. Endocrinology, vol 151., pp. 5369 - 5379 Atkinson, H, Leggett, J, Wood, S, Castrique, E, Kershaw, Y & Lightman, S, 2010, ‘Regulation of the hypothalamic-pituitary-adrenal axis circadian rhythm by endocannabinoids is sexually diergic’. Endocrinology, vol 151 (8)., pp. 3720 - 3727 Cameron, G, Henley, D, Carrell, R, Zhou, A, Clarke, A & Lightman, S, 2010, ‘Temperature-responsive release of cortisol from its binding globulin: A protein thermocouple’. The Journal of Clinical Endocrinology & Metabolism, vol 95 (10)., pp. 4689 - 4695