Research activities in the laboratory focus on investigating the replication and pathogenesis of Dengue virus and SARS coronavirus with an overall aim of developing improved antiviral agents and vaccines

Décembre, E., Assil, S., Hillaire, M. L. B., Dejnirattisai, W., Mongkolsapaya, J., Screaton, G. R., Davidson, A. D. and Dreux, M. (2014) Sensing of immature particles produced by dengue virus infected cells induces an antiviral response by plasmacytoid dendritic cells. PLOS Pathogens 10, e1004434. Chiu, H-C., Hannemann, H., Heesom, K. J., Matthews, D. A. and Davidson, A.D. (2014) High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells PLOS ONE 9 3, e93305. Hannemann, H., Sung, P-Y, Chui, H-C, Bird, J, Lim, S.P., and Davidson, A.D. (2013) Serotype specific differences in dengue virus non-structural protein 5 nuclear localization J. Biol. Chem. 288, 22621-22635. Kumar, A., Bühler, S., Selisko, B., Davidson, A., Mulder, K., Canard, B., Miller, S. and Bartenschlager, R. (2013) Nuclear localization of Dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling. J. Virol. 87, 4545-4557. van den Worm, S.H.E., Eriksson, K.K., Zevenhoven, J.C., Weber, F., Züst, R., Kuri, T., Dijkman, R., Chang, G., Siddell, S.G., Snijder, E.J., Thiel, V., and Davidson, A.D. (2012) Reverse genetics of SARS-related coronavirus using vaccinia virus-based recombination. PLOS ONE 7(3), e32857. Kuri, T., Eriksson, K.K., Putics, A., Züst, R., Snijder, E.J., Davidson, A.D., Siddell, S.G., Thiel, V., Ziebuhr, J. and Weber, F. (2011) The ADP-ribose-1’’-monophosphatase domains of SARS-coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses. J. Gen. Virol. 92 (8), 1899-1905. Mazzon, M., Jones, M., Davidson, A., Chain, B. and Jacobs, M. (2009) Dengue virus NS5 inhibits interferon-α signalling by blocking STAT2 phosphorylation. J. Infect. Dis. 200, 1261-1270. Davidson, A.D. (2009) New insights into flavivirus nonstructural protein 5. Advances in Virus Research 74, 41-101. Kroschewski, K., Lim, S. P., Butcher, R.E., Yap, T.L., Lescar, J., Wright, P.J., Vasudevan, S.G. and Davidson, A.D. (2008) Mutagenesis of the Dengue virus type 2 NS5 methyltransferase domain. J. Biol. Chem. 283, 19410-19421. Pryor, M.J., Rawlinson, S.M., Butcher, R.E., Barton, C.L., Waterhouse, T.A., Vasudevan, S.G., Bardin, P.G., Wright, P.J., Jans, D.A. and Davidson, A.D. (2007) Nuclear localization of dengue virus NS5 through its importin α/β–recognized NLS is integral to viral infection. Traffic 8, 795-807.