Synaptic Plasticity and Alzheimer's Disease

Jo, J, Whitcomb, DJ, Olsen, KM, Kerrigan, TL, Lo, S-C, Bru-Mercier, G, Dickinson, B, Scullion, S, Sheng, M, Collingridge, G & Cho, K, 2011, ‘Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β’. Nature Neuroscience, vol 14., pp. 545 - 547 Li, Z, Jo, J, Jia, J, Lo, S, Whitcomb, D, Jiao, S, Cho, K & Sheng, M, 2010, ‘Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization’. Cell, vol 141., pp. 859 - 871 Whitehead, G, Jo, J, Hogg, EL, Piers, T, Kim, D-H, Seaton, G, Seok, H, Bru-Mercier, G, Son, GH, Regan, PL, Hildebrandt, L, Waite, E, Kim, B-C, Kerrigan, TL, Kim, K, Whitcomb, DJ, Collingridge, GL, Lightman, SL & Cho, K, 2013, ‘Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus’. Brain, vol 136., pp. 3753-3765 Whitcomb, DJ, Hogg, EL, Regan, P, Piers, T, Narayan, P, Whitehead, G, Winters, BL, Kim, DH, Kim, E, St George-Hyslop, P, Klenerman, D, Collingridge, GL, Jo, J & Cho, K, 2015, ‘Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus’. Scientific Reports, vol 5. Regan, P, Piers, T, Yi, JH, Kim, DH, Huh, S, Park, SJ, Ryu, JH, Whitcomb, DJ & Cho, K, 2015, ‘Tau phosphorylation at serine 396 residue is required for hippocampal LTD’. The Journal of Neuroscience, vol 35., pp. 4804-4812 Lee, K, Kim, J, Kwon, O, An, K, Ryu, J, Cho, K, Suh, Y & Kim, H, 2012, ‘An Activity-Regulated microRNA, miR-188, Controls Dendritic Plasticity and Synaptic Transmission by Downregulating Neuropilin-2’. J Neurosci, vol 18;32(16)., pp. 5678 - 5687 Jo, J, Son, G, Winters, B, Kim, M, Whitcomb, D, Dickinson, B, Lee, Y, Futai, K, Amici, M, Sheng, M, Collingridge, G & Cho, K, 2010, ‘Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95’. Nature Neuroscience, vol 13., pp. 1216 - 1224 Jang, S, Oh, D, Lee, Y, Hosy, E, Shin, H, van Riesen, C, Whitcomb, D, Warburton, JM, Jo, J, Kim, D, Kim, SG, Um, SM, Kwon, S-K, Kim, M-H, Roh, JD, Woo, J, Jun, H, Lee, D, Mah, W, Kim, H, Kaang, B-K, Cho, K, Rhee, J-S, Choquet, D & Kim, E, 2016, ‘Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity’. Nature Neuroscience, vol 19., pp. 84-93 Regan, PL, Whitcomb, DJ & Cho, K, 2016, ‘Physiological and Pathophysiological Implications of Synaptic Tau’. Neuroscientist.