Chromatin Remodelling and Genome Stability

Schalbetter, S, Mansoubi, S, Chambers, A, Downs, J & Baxter, J, 2015, ‘Fork rotation and DNA pre-catenation is restricted during DNA replication to prevent chromosomal instability’. Proceedings of the National Academy of Sciences of the United States of America, vol 112., pp. E4565?E4570 Kakarougkas, A, Ismail, A, Chambers, AL, Riballo, E, Herbert, AD, Künzel, J, L?brich, M, Jeggo, PA & Downs, JA, 2014, ‘Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin’. Molecular Cell, vol 55., pp. 723-32 Brownlee, PM, Chambers, AL, Cloney, R, Bianchi, A & Downs, JA, 2014, ‘BAF180 promotes cohesion and prevents genome instability and aneuploidy’. Cell Reports, vol 6., pp. 973-81 Chambers, AL, Pearl, LH, Oliver, AW & Downs, JA, 2013, ‘The BAH domain of Rsc2 is a histone H3 binding domain’. Nucleic acids research, vol 41., pp. 9168-82 Chambers, AL, Ormerod, G, Durley, SC, Sing, TL, Brown, GW, Kent, NA & Downs, JA, 2012, ‘The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres’. Genes & development, vol 26., pp. 2590-603 Brownlee, PM, Chambers, AL, Oliver, AW & Downs, JA, 2012, ‘Cancer and the bromodomains of BAF180’. Biochemical Society transactions, vol 40., pp. 364-9 Chambers, AL & Downs, JA, 2012, ‘The RSC and INO80 chromatin-remodeling complexes in DNA double-strand break repair’. Progress in molecular biology and translational science, vol 110., pp. 229-61 Niimi, A, Chambers, AL, Downs, JA & Lehmann, AR, 2012, ‘A role for chromatin remodellers in replication of damaged DNA’. Nucleic acids research, vol 40., pp. 7393-403 Chambers, AL, Brownlee, PM, Durley, SC, Beacham, T, Kent, NA & Downs, JA, 2012, ‘The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses’. PloS one, vol 7., pp. e32016 Kent, NA, Chambers, AL & Downs, JA, 2007, ‘Dual chromatin remodeling roles for RSC during DNA double strand break induction and repair at the yeast MAT locus’. Journal of Biomedical Material Research: Applied Biomaterials, vol 282., pp. 27693-701