Mark Bond completed his BSc in Molecular and Cellular Biology at the University of Nottingham in 1994. He then joined Prof. Andrew Newby’s group, initially at the University of Cardiff, Wales (later moving with Prof. Newby to Bristol) to study the regulation of matrix metalloproteinase gene expression by inflammatory cytokines and growth factors. Following his PhD, he joined Dr Andrew Baker’s group to study the mechanistic basis for the pro-apoptotic effects of TIMP3. Following this, he returned to Prof Newby’s group as a lecturer, studying the regulation of vascular smooth muscle cell proliferation, with a particular emphasis on the role of novel cAMP-dependent signalling pathways. Dr Bond is currently a senior lecturer at the University of Bristol.

Transcriptional regulation of vascular cell behaviour

Arun, MZ, Reel, B, Sala-Newby, GB, Bond, M, Tsaousi, A, Maskell, P & Newby, AC, 2016, ‘Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress’. Drug Design, Development and Therapy, vol 2016., pp. 1453-1460 Kimura-Wozniak, T, Duggirala, A, Smith, MC, White, SJ, Sala-Newby, G, Newby, AC & Bond, M, 2015, ‘The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP’. Journal of Molecular and Cellular Cardiology, vol 90., pp. 1-10 Kimura, TE, Duggirala, A, Hindmarch, CCT, Hewer, RC, Cui, M-Z, Newby, AC & Bond, M, 2014, ‘Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells’. Journal of molecular and cellular cardiology, vol 72., pp. 9-19 Duggirala, A, Kimura, TE, Sala-Newby, GB, Johnson, JL, Wu, Y-J, Newby, AC & Bond, M, 2014, ‘cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1’. Journal of Molecular and Cellular Cardiology, vol 79., pp. 157-168 Bond, M & Wu, Y-J, 2011, ‘Proliferation unleashed: the role of Skp2 in vascular smooth muscle cell proliferation’. Front Biosci, vol 1;16., pp. 1517 - 1535 Hewer, R, Sala-Newby, G, Wu, Y, Newby, A & Bond, M, 2011, ‘PKA and Epac synergistically inhibit smooth muscle cell proliferation’. Journal of Molecular and Cellular Cardiology, vol 50., pp. 87 - 98 Ivette, H-N, B, S-N, Andras, P, R, KG, Newby, A & Bond, M, 2011, ‘Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription-activating factor (STAF)’. Biochemical Journal, vol 436., pp. 133-143 Wu, Y-J, Sala-Newby, G, Shu, K, Yeh, H, Nakayama, K, Nakayama, K, Newby, A & Bond, M, 2009, ‘S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo’. Journal of Vascular Surgery, vol 50., pp. 1135 - 1142 Muzaffar, S, Shukla, N, Bond, M, Newby, A, Angelini, G, Sparatore, A, Soldato, PD & Jeremy, J, 2008, ‘Exogenous Hydrogen Sulfide Inhibits Superoxide Formation, NOX-1 Expression and Rac(1) Activity in Human Vascular Smooth Muscle Cells’. J Vasc Res, vol 7;45(6)., pp. 521 - 528 Muzaffar, S, Shukla, N, Bond, M, Sala-Newby, G, Newby, A, Angelini, G & Jeremy, J, 2008, ‘Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate’. British Journal of Pharmacology, vol 155., pp. 847 - 856