Novel Two-component signal transduction systems in bacteria - functional genomic analyses. Regulation of chromosomal β-lactamase production in Gram-negative bacteria - biochemical and molecular genetic analyses. Functional analysis and regulation of multidrug efflux pump expression in Gram-negative bacteria. Antibiotic induced mutation and bacteriophage induction in Campylobacter jejuni and E. coli. Predicting evolutionary potential of mobile antimicrobial drug resistance genes. Testing novel antimicrobial drugs and inhibitors of antibiotic resistance.

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