Neurotrophins and Neurodegeneration

Kailainathan, S, Piers, TM, Yi, JH, Choi, SM, Fahey, MS, Borger, E, Gunn-Moore, FJ, O'Neill, L, Lever, M, Whitcomb, DJ, Cho, K & Allen, SJ, 2015, ‘Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)’. Pharmacological Research, vol 104., pp. 97-107 Shoemark, DK, Williams, C, Fahey, MS, Watson, JJ, Tyler, SJ, Scoltock, SJ, Ellis, R, Wickendon, E, Burton, AJ, Hemmings, JLL, Bailey, CD, Dawbarn, D, Jane, DE, Willis, CL, Sessions, RB, Allen, SJ & Crump, MP, 2015, ‘Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery’. Journal of Medicinal Chemistry, vol 58., pp. 767-777 Frias, B, Santos, J, Morgado, M, Sousa, MM, Gray, SMY, McCloskey, KD, Allen, S, Cruz, F & Cruz, CD, 2015, ‘The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO)’. The Journal of Neuroscience, vol 35., pp. 2146-60 Shoemark, DK & Allen, SJ, 2014, ‘The Microbiome and Disease: Reviewing the Links between the Oral Microbiome, Aging, and Alzheimer's Disease’. J Alzheimers Dis, vol 43., pp. 725-38 Allen, SJ, Watson, JJ, Shoemark, DK, Barua, NU & Patel, NK, 2013, ‘GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration’. Pharmacology & Therapeutics, vol 138., pp. 155 Crompton, LA, Byrne, ML, Taylor, H, Kerrigan, TL, Bru-Mercier, G, Badger, JL, Barbuti, PA, Jo, J, Tyler, SJ, Allen-Birt, SJ, Kunath, T, Cho, K & Caldwell, MA, 2013, ‘Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling’. Stem Cell Research, vol 11., pp. 1206-1221 Wang, H, Sessions, RB, Prime, SS, Shoemark, DK, Allen-Birt, SJ, Hong, W, Narayanan, S & Paterson, IC, 2013, ‘Identification of novel small molecule TGF-β antagonists using structure-based drug design’. Journal of Computer Aided Design, vol 27., pp. 365-372 Frias, B, Allen-Birt, SJ, Dawbarn, D, Charrua, A, Cruz, F & Cruz, CD, 2013, ‘Brain Derived Neurotrophic Factor (BDNF), acting at the spinal cord level, participates in bladder hyperactivity in and referred pain chronic bladder inflammation’. BMC Neuroscience, vol 234., pp. 88-102 Allen, S, Watson, J & Dawbarn, D, 2011, ‘The neurotrophins and their role in Alzheimer's disease’. Current Neuropharmacology, vol 9., pp. 559 - 573 Watson, J, Shoemark, D, Hemmings, JL, Tyler, S, Fahey, M, Williams, C, Bailey, C, McArdle, C, Caunt, J, Jane, D, Sessions, R, Crump, M, Willis, C & Allen-Birt, S, 2011, ‘Towards a model of sporadic Alzheimer’s disease: aiding design of small molecule TrkA agonists’. in: Alzheimer's & Dementia. Elsevier, pp. S802