Develop methodologies to monitor the pharmacokinetics and metabolism of anticancer drugs Perform analyses of clinical and pre-clinical samples using High Performance Liquid Chromatography and Mass Spectrometry technologies, within a Quality Management (GCLP) environment Undertake method validation for drugs entering clinical trials, to high quality standards, for external collaborators Apply methodologies to determine pharmacodynamic endpoints for anticancer drugs in clinical trials

Phillips RM, Jaffar M, Maitland DJ, Loadman PM, Shnyder SD, Steans G, Cooper PA, Race A, Patterson AV and Stratford IJ, Pharmacological and biological evaluation of a series of substituted 1,4 naphthoquinone bioreductive drugs. Biochemical Pharmacology 68: 2107-2116, 2004