BSc(Hons) First Class in Biochemistry, 1987, University of Manchester PhD in Biochemistry, 1991, University of Glasgow 1997-2014: Lecturer (1997-2004), Senior Lecturer (2004-2008) and Reader (2008-2014), University of Glasgow, Scotland, UK 1991-1997: Postdoctoral Research Associate and American Heart Association Research Fellow, Duke University Medical Centre, Durham, North Carolina, USA 2015 – present: Honorary Senior Research Fellow, Institute of Cardiovascular & Medical Sciences, University of Glasgow, Scotland, UK

Cardiovascular Disease; Regulation of Cytokine Signalling; Identification and Validation of New Signalling Pathway Targets

Rutherford C, Palmer TM. Regulation of Adenosine Receptor Desensitisation and Function, for "Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects" 2015 (Editors. V Ramkumar, RP de Carvalho) Nova Science Publishing ISBN: 978-1-63483-186-4 Parnell E, Palmer TM, Yarwood SJ. The future of EPAC-targeted therapies: agonism versus antagonism. Trends Pharmacol Sci. 2015;36:203-214 Williams JJL, Munro KMA, Palmer TM. Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression. Cells 2014; 3:546-562; doi:10.3390/cells3020546 Williams JJL, Palmer TM. Cavin-1: caveolae-dependent signalling and cardiovascular disease. Biochem. Soc. Trans. 2014; 42:284-88 Rutherford C, Childs S, Ohotski J, McGlynn L, Riddick M, MacFarlane S, Tasker D, Pyne S, Pyne NJ, Edwards J, Palmer TM. Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated up-regulation of Mcl-1, Cell Death and Disease 2013;4, e927; doi:10.1038/cddis.2013.455 Cannavo A, Rengo G, Liccardo D, Pagano G, Zincarelli C, De Angelis MC, Puglia R, Di Pietro E, Rabinowitz J, Barone MV, Cirillo P, Trimarco B, Palmer TM, Koch W, Leosco D, Rapacciuolo A. ?1-adrenergic receptor and Sphingosine-1-phosphate receptor 1 reciprocal down-regulation influences cardiac hypertrophic response and progression toward heart failure: protective role of S1PR1 cardiac gene therapy. Circulation. 2013 Oct 8;128(15):1612-1622 Long JS, Crighton D, O'Prey J, Mackay G, Zheng L, Palmer TM, Gottlieb E, Ryan KM. Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Mol Cell. 2013 May 9;50(3):394-406 Dondelinger F, Rogers S, Filippone M, Cretella R, Palmer TM, Smith R, Millar A, Husmeier D. (2012) Parameter inference in mechanistic models of cellular regulation and signalling pathways using gradient matching. In: WCSB2012 - 9th International Workshop on Computational Systems Biology, 4-6 Jun 2012, Ulm, Germany Salt IP, Palmer TM. Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opin. Investig. Drugs, 2012; 21:1155-67 Jones SE, Palmer TM. Protein kinase A-mediated phosphorylation of RhoA on serine 188 triggers the rapid induction of a neuroendocrine-like phenotype in prostate cancer epithelial cells. Cell. Signal. 2012; 24:1504–14 Rutherford C, Woolson HD, Palmer TM. Cross-Regulation of JAK-STAT Signalling: Implications For Approaches to Combat Chronic Inflammatory Diseases and Cancers in "Protein Kinases / Book 2 (Editor: Dr. Gabriela Da Silva Xavier)" In-Tech Publishers, 2012, ISBN 979-953-307-890-7 Williams JJL, Palmer TM. Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3. Biochem. Soc. Trans. 2012; 40:215-18 Milne GR, Palmer TM, Yarwood SJ. Novel control of cAMP-regulated transcription in vascular endothelial cells. Biochem Soc Trans. 2012; 40:1-5 Sands WA, Woolson HD, Yarwood SJ, Palmer TM. Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter. Methods Mol Biol. 2012; 809:201-14 Parnell E, Smith BO, Palmer TM, Terrin A, Zaccolo M, Yarwood SJ. Regulation of the Inflammatory Response of Vascular Endothelial Cells by EPAC1. Br J Pharmacol. 2012; 166:434–446 Williams JJL, Palmer TM. Interleukin-6 (IL6) signalling and its role in the development of cardiovascular disease, in "Endothelium and Epithelium: Composition, Functions and Pathology" (Editors: Jo?o Carrasco and Matheus Mota), 157-173, Nova Publishers, 2011, ISBN 978-1-61470-874-2 Milne GR, Palmer, TM. Anti-inflammatory and immunosuppressive effects of the A2A adenosine receptor. The Scientific World Journal 2011 11:320-339 Rutherford C, Palmer TM. Molecular basis of protective anti-inflammatory signalling by cyclic AMP in the vascular endothelium, in "Systems Biology of Signaling Networks" (Editor Sangdun Choi). 561-588, Springer, 2010, ISBN: 978-1-4419-5796-2 Safhi MMA, Rutherford C, Ledent C, Sands WA, Palmer TM. Priming of signal transducer and activator of transcription proteins for cytokine-triggered polyubiquitylation and degradation by the A2A adenosine receptor. Mol. Pharmacol. 2010 77:968–978 Mundell SJ, Matharu A-L, Palmer TM, Benovic JL, Kelly E. Deletion of the distal COOH-terminus of the A2B adenosine receptor switches agonist-induced internalisation to an arrestin- and clathrin-independent pathway and inhibits receptor recycling. Br J Pharmacol 2010 159:518–533 Woolson HD, Thompson VS, Rutherford C, Yarwood SJ, Palmer TM. Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3. Cell. Signal. 2009 21:1706–1715 Borland G, Bird R, Palmer TM, Yarwood SJ. Activation of protein kinase Cα by EPAC1 is required for the ERK- and C/EBP?-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. J. Biol. Chem. 2009 284:17391–17403 Yarwood SJ, Borland G, Sands WA, Palmer TM. Identification of C/EBPs as EPAC-activated transcription factors that mediate the induction of the SOCS-3 gene. J Biol Chem. 2008 283(11):6843-53 Mair KM, MacLean MR, Morecroft I, Dempsie Y, Palmer TM. Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. Br J Pharmacol. 2008 155:606-616 Palmer TM, Trevethick MA. Suppression of inflammatory and immune responses by the A(2A) adenosine receptor: an introduction. Br J Pharmacol. 2008 153:S27–S34 Sands WA, Palmer TM. Regulating gene transcription in response to cyclic AMP elevation. Cell Signal. 2008 Mar;20(3):460-6