PhD (Bradford), BSc Hons (CNAA), CBiol MRSB

Pharmacokinetics and tumour drug metabolism of anti cancer drugs Matrix metalloproteinases as targets for tumour-selective delivery of anticancer therapeutics Drug delivery and prodrug design Novel advances in analytical techniques. HPLC, GC, CE and LC/MS/MS Drug interactions both in vitro and in vivo

Proteases in cancer drug delivery, Jennifer Vandooren, Ghislain Opdenakker, Paul M. Loadman, Dylan R. Edwards, Advanced Drug Delivery Reviews, (2016),97,144–155 doi:10.1016/j.addr.2015.12.020 Probing cytochrome P450-mediated activation with a truncated azinomycin analogue, Victoria Vinader, Maria Sadiq, Mark Sutherland, Mengying Huang, Paul M. Loadman, Lina Elsalem, Steven D. Shnyder, Hongjuan Cui, Kamyar Afarinkia, Mark Searcey, Laurence H. Patterson and Klaus Pors, Med. Chem. Commun., 2015,6, 187-191 Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treated with the vascular disrupting agent DMXAA, Afnan Batubara, Vikki A Carolan, Paul M. Loadman, Chris Sutton, Steve D. Shnyder and Malcolm R. Clench Rapid Commun. Mass Spectrom. 2015, 29, 1–9 Andrew J Cockbain, Milene Volpato, Amanda D Race, Alessandra Munnarini, Chiara Fazio, Andrea Belluzzi, Paul M Loadman, Giles J Toogood, Mark A Hull, Anti-colorectal cancer activity of the omega-3 fatty acid eicosapentaenoic acid, (2014) Gut;63(11):1760-8 Jason H. Gill, Paul M. Loadman, Steven D. Shnyder, Patricia Cooper, Laurence H.Patterson, Jennifer M. Atkinson, Goretti Ribeiro Morais, Robert A. Falconer The Tumor-Targeted Vascular Disrupting Agent ICT2588 Demonstrates Therapeutic Activity Against Solid Tumours and Reduced Potential For Cardiovascular Toxicity.. (2014) Mol. Pharmaceutics, 11, 1294?1300 Piazzi, Giulia; D'argenio, Giuseppe; Prossomariti, Anna; Lembo, Vincenzo; Mazzone, Giovanna; Candela, Marco; Biagi, Elena; Brigidi, Patrizia; Vitaglione, Paola; Fogliano, Vincenzo; D'angelo, Leonarda; Fazio, Chiara; Munarini, Alessandra; Belluzzi, Andrea; Ceccarelli, Claudio; Chieco, Pasquale; Balbi, Tiziana; Loadman, Paul; Hull, Mark; Romano, Marco; Bazzoli, Franco; Ricciardiello, Luigi, Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota, (2014), International Journal of Cancer. 135(9):2004-13 Mathematical and Computational Models of Drug Transport in Tumours. C.M.Groh, M.E.Hubbard, P.F.Jones, P.M.Loadman, N.Periasamy, B.D.Sleeman, S.W.Smye, C.J.Twelves, R.M.Phillips, (2014), Journal of the Royal Society Interface,11(94) In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog Wong CC1, Periasamy N, Sagineedu SR, Sidik S, Sumon SH, Loadman PM, Phillips R, Lajis NH, Stanslas J., Investigational New Drugs.(2014),32(5):806-14 Prashant Kant, Sarah L Perry, Simon P Dexter, Amanda D Race, Paul M Loadman, Mark A Hull Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass, Obesity (2014), 22, 1, 202–210 Marie-Claude Djidja, Simona Francese, Emmanuelle Claude, Paul M Loadman, Chris Sutton, Steve Shynder, Patricia Cooper, Laurence H Patterson, Vikki A Carolan and Malcolm R. Clench, Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imaging, (2013), Current Analytical Chemistry. 9, 4 212- 225 Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH., Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Mol Cancer Ther. (2013);12(1):27-37 Mark A Hull, Anna C Sandell, Min Yang, Richard F A Logan, Gayle M Clifford, Colin J Rees, Paul M Loadman, Diane Whitham, A randomised controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: The seAFOod (Systematic Evaluation of Aspirin and Fish Oil) Polyp Prevention Trial, (2013), Trials. 2013 Jul 29;14(1):237 Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.Sheldrake HM, Travica S, Johansson I, Loadman PM, Sutherland M, Elsalem L, Illingworth N, Cresswell AJ, Reuillon T, Shnyder SD, Mkrtchian S, Searcey M, Ingelman-Sundberg M, Patterson LH, Pors K. (2013), J Med Chem. Aug 8;56(15):6273-7 Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins Sandra Travica, Klaus Pors, Paul M. Loadman, Steve D. Shnyder, Inger Johansson, Mohammed N. Alandas, Helen M. Sheldrake, Souren Mkrtchian, Laurence H. Patterson, and Magnus Ingelman-Sundberg, (2013), Clinical Cancer Research;(19):2952-2961 Celina Ansari, Grigory A. Tikhomirov, Su Hyun Hong, Jason Gill, Robert Falconer, Paul M. Loadman, Rosalinda Castaneda, Florette K. Hazard, Ling Tong, Dean W. Felsher, Jianghong Rao, Heike E. Daldrup-Link, Development of Novel Activatable Theranostic Nanoparticles for combined Cancer MR Imaging and Therapy, (2013), Small., Volume 10, Issue 3, 417 Yousef M. J. Al-Saraireh, Mark Sutherland, Bradley R. Springett, Friedrich Freiberger, Goreti Ribeiro Morais, Paul M. Loadman, Rachel J. Errington, Paul J. Smith, Minoru Fukuda, Rita Gerardy-Schahn, Laurence H. Patterson, Steven D. Shnyder, and Robert A. Falconer, Inhibition of polysialyltransferase ST8SiaII by cytidine monophosphate modulates tumor cell migration, PLoS One 09 Aug (2013) Sadr-ul-Shaheed, Nitin Rustogi , Andrew Scally, Julie Wilson, Helene Thygesen, Maria A. Loizidou, Andreas Hadjisavvas, Andrew Hanby, Valerie Speirs, Paul M. Loadman, Kyriacos Kyriacou, Chris W. Sutton, Identification of Stage-Specific Breast Markers using Quantitative Proteomics (2013), Journal of Proteome Research, 12 (12), pp 5696–5708 Hawcroft, G.; Volpato, M.; Marston, G.; Ingram, N.; Perry, S.; Cockbain, A.; Race, A.; Munarini, A.; Belluzzi, A.; Loadman, P.; Coletta, P; Hull, M., The ω-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of prostaglandin E2-dependent cell motility, B. J. of Pharmacology, (2012), 166, 5, 1724–37 Tomlinson DC, Baxter EW, Loadman PM, Hull MA, Knowles MA. FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCγ/COX-2-Mediated Mechanisms. PLoS One. (2012);7(6) Laura Cosentino, Mariano Redondo-Horcajo, Ying Zhao, Ana Rita Santos, Kaniz F. Chowdury, Victoria Vinader, Qasem M. A. Abdallah, Hamdy Abdel-Rahman, Je?re?mie Fournier-Dit-Chabert, Steven D. Shnyder, Paul M. Loadman, Wei-shuo Fang, Jose? Fernando Díaz, Isabel Barasoain, Philip A. Burns, and Klaus Pors, Synthesis and Biological Evaluation of Colchicine B?Ring Analogues Tethered with Halogenated Benzyl Moieties, J. Med. Chem., (2012), 55, (24), 11062-6 Fournier-Dit-Chabert J, Vinader V, Santos AR, Redondo-Horcajo M, Dreneau A, Basak R, Cosentino L, Marston G, Abdel-Rahman H, Loadman PM, Shnyder SD, Díaz JF, Barasoain I, Falconer RA, Pors K. Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation., Bioorg Med Chem Lett. 2012. Dec 15; 22(24):7693-6