Dermal and transdermal drug delivery Drug-biomembrane interactions by using liposomes as model membranes Quantitative structure-pharmacokinetics relationships of drugs Dermal and transdermal drug delivery Drug-biomembrane interactions by using liposomes as model membranes Quantitative structure-pharmacokinetics relationships of drugs Current Projects Mechanisms of drug interaction with biomembranes Transdermal and dermal drug delivery Current Projects Mechanisms of drug interaction with biomembranes Transdermal and dermal drug delivery

Michael H Abraham, Joelle MR Gola, Adam Ibrahim, William E. Acree Jr, Xiangli Liu. The prediction of blood-tissue partitions, water-skin partitions and skin permeation for agrochemicals, Pest Manag Sci. DOI 10.1002/ps.3658 (2013) Michael H Abraham, William E. Acree Jr, Alfred Fahr, Xiangli Liu. Analysis of immobilized artificial membrane retention factors for both neutral and ionic species, J Chromatogr. A, 1298, 44-49 (2013) Keda Zhang, Ming Chen, Gerhard Scriba, Michael H. Abraham, Alfred Fahr, Xiangli Liu. Human skin permeation of neutral species and ionic species: extended linear free-energy relationship analyses, J. Pharm. Sci., 101, 2034-2044 (2012) Kewei Yang, Burkhard Gitter, Ronny Rüger, Gerhard D. Wieland, Ming Chen, Xiangli Liu, Volker Albrecht, Alfred Fahr, Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamic antimicrobial chemotherapy. Photochemical & Photobiological Science, 10, 1593-1601 (2011) Keda Zhang, Ming Chen, Gerhard Scriba, Michael H. Abraham, Alfred Fahr, Xiangli Liu. Linear free energy relationship (LFER) analysis of retention factor in cerasome electrokinetic chromatography intended for predicting drug skin permeation, J. Pharm. Sci., 100, 3105-3113 (2011) Hossam Hefesha, Stephan Loew, Xiangli Liu, Sylvio May, Alfred Fahr, Transfer Mechanism of Temoporfin between Liposomal Membranes, J. Control. Rel., 150, 279-286 (2011) Peter van Hoogevest, Xiangli Liu, Alfred Fahr, Drug delivery strategies for poorly water-soluble drugs from the industrial perspective, Expert. Opin. Drug Deliv. 8, 1481-1500 (2011) Xiangli Liu, Bernard Testa, Alfred Fahr. Lipophilicity and its relationship with passive drug permeation, Pharm. Res., 28, 962-977 (2011) Peter van Hoogevest, Xiangli Liu, Alfred Fahr, Mathew L.S. Leigh. Role of phospholipids in the oral and parenteral delivery of poorly water soluble drugs, J. Drug Del. Sci. Tech., 21(1), 5-16 (2011) Ming Chen, Xiangli Liu, Alfred Fahr. Skin penetration and deposition of CF and mTHPC from different lipid vesicles--finite and infinite dosage application, Int. J. Pharm., 408, 223-234 (2011) Ming Chen, Xiangli Liu, Alfred Fahr. Skin delivery of ferulic acid from different liposomal systems, Journal of Biomedical Nanotechnology, 6, 577-585 (2010) Jiantao Zhang, Silvia Petersen, Mahendra Thunga, E Leipold, Roland Weidisch, Xiangli Liu, Alfred Fahr, & Klaus D. Jandt. Micro-Structured Smart Hydrogels with Enhanced Protein Loading and Release Efficiency, Acta Biomater, 6, 1297-1306 (2010) Xiangli Liu, Ping Fan, Ming Chen, Gerhard K.E. Scriba, Detlef Gabel, Alfred Fahr. Drug-membrane interaction on immobilized liposome chromatography compared to immobilized artificial membrane (IAM), liposome/water and n-octanol/water systems, Helv. Chim. Acta, 93, 203-211 (2010)