Graduate in Physics from University of S?o Paulo, Brazil PhD in Neurophysiology from the University of S?o Paulo, Brazil Research Fellow at the School of Life Sciences, University of Manchester Research Associate at the MRC Centre for Synaptic Plasticity, University of Bristol Senior Research Fellow at the School of Life Sciences, University of Warwick

The research in my lab is focuses on understanding the molecular mechanisms regulating modulations in glutamatergic synaptic transmission in the hippocampus. Long-term modulation in synaptic transmission, also termed synaptic plasticity, is thought to provide the molecular substrate that underlies learning and memory formation. We use a wide range of techniques including molecular and cell biology, biochemistry, immunocytochemistry combined with confocal imaging and electrophysiological recordings to study the mechanisms regulating endocytosis of glutamate receptors during synaptic plasticity. Understanding the molecular mechanisms underlying modulation in synaptic transmission has become very timely, as it will provide insights into normal and abnormal functioning of the brain and may find novel therapeutic targets to slow cognitive decline associated with ageing and neurodegenerative diseases.

Ageing of the brain; Learning and memory; Neurodegenerative diseases; Therapeutics targets; Synaptic plasticity; Trafficking of transmembrane receptors

Eales KL, Palygin O, O’Loughlin T, Rasooli-Nejad S, Gaestel M, Müller J, Collins DR, Pankratov Y and Corrêa SAL. (2014) The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat. Commun., 5:4701 doi:1038/ncomms5701 Mabb AM, Je HS, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SAL, Ehlers MD (2014) Triad3A Regulates Synaptic Strength by Ubiquitination of Arc. Neuron, 82(6):1299-1316 Corrêa SAL, Hunter CJ, Palygin O, Wauters S, Martin KJ, Mackenzie C, McKelvey K, Morris RGM, Pankratov Y, Arthur JSC, Frenguelli BG (2012) MSK1 regulates homeostatic and experience-dependent synaptic plasticity. J Neurosci., 32(38):13039-13051 Canal F, Palygin O, Pankratov Y, Corrêa, SAL, Müller J. (2011) Feedback regulation of the MAP kinase scafold protein KSR1 regulates synaptic plasticity in hippocampal neurons. FASEB J 25(7):2362-72 Baines, AE, Corrêa, SAL, Irving AJ, Frenguelli BG (2011) Differential trafficking of adenosine receptors in hippocampal neurons monitored using GFP- and super ecliptic pHluorin-tagged receptor. Neuropharmacology 61:1-11 Appleby, VJ, Corrêa, SAL, Duckworth JK, Nash, JE, Noel J, Fitzjohn SM, Collingridge, GL, Molnar E (2011) LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression. J Neurochem, 116(4):530-43 Nash, JE, Appleby VJ, Corrêa SAL, Wu H, Garner CC, Fitzjohn SM, Collingridge, GL, Molnar E (2010) Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses. J Neurochem, 112(3):677-90 Corrêa SAL, Müller J., Collingridge, GL Marrion, NV. (2009) Rapid endocytosis provides restricted somatic expression of a potassium channel in central neurons. J Cell Sci., 122:4186-4194 Kantamneni, S, Holman, D, Wilkinson KA, Corrêa SAL, Feligioni M, Odgen S, Fraser W, Nishimune, A, Henley JM (2008) GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation. J Neurochem, 107(1):86-95 Moult PR, Corrêa SAL, Collingridge GL, Fitzjohn SM, Bashir ZI (2008) Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase: a novel signalling mechanism underlying synaptically induced metabotropic glutamate receptor-dependent long-term depression in the hippocampus. J. Physiology, 15; 586(10): 2499-510