B.A., Mount Holyoke College, 1997 Ph.D., Medical College of Wisconsin 2007 Postdoctoral Fellow, The Scripps Research Institute and University of California, San Diego, 2007-2012.

Analytical, Biochemistry, & Biology

My research group focuses on utilizing novel technologies to develop new therapeutics and diagnostics for autoimmune and inflammatory diseases. The development of mutli-functional drugs, i.e. theranostics, allows simultaneous imaging of tissue pathology coupled with treatment, increasing efficacy and reducing toxicity. To this end, my group uses mass spectrometry-based metabolomics, molecular imaging, and viral nanoparticles to identify and target cellular pathways that are involved in disease pathogenesis.

Plummer EM, Thomas D, Destito G, Shriver LP, Manchester M. (2012) Interaction of cowpea mosaic virus nanoparticles with surface vimentin and inflammatory cells in atherosclerotic lesions. Nanomedicine (Lond). 7(6):877-88

Patti GJ, Yanes O, Shriver LP, Courade JP, Tautenhahn R, Manchester M, Siuzdak G. (2012) Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat Chem Biol. 22;8(3):232-4.

Shriver LP, Manchester M. (2011) Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Sci Rep. 1:79.

Patti GJ, Shriver LP, Wassif CA, Woo HK, Uritboonthai W, Apon J, Manchester M, Porter FD, Siuzdak G. (2010) Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome. Neuroscience. 170(3):858-64.

Patti GJ, Woo HK, Yanes O, Shriver L, Thomas D, Uritboonthai W, Apon JV, Steenwyk R, Manchester M, Siuzdak G. (2010) Detection of carbohydrates and steroids by cation-enhanced nanostructure-initiator mass spectrometry (NIMS) for biofluid analysis and tissue imaging. Anal Chem. 2010 Jan 1;82(1):121-8.

Shriver LP, Koudelka KJ, Manchester M. (2009) Viral nanoparticles associate with regions of inflammation and blood brain barrier disruption during CNS infection. J Neuroimmunol. 211(1-2):66-72.

Yanes O, Woo HK, Northen TR, Oppenheimer SR, Shriver L, Apon J, Estrada MN, Potchoiba MJ, Steenwyk R, Manchester M, Siuzdak G. (2009) Nanostructure initiator mass spectrometry: tissue imaging and direct biofluid analysis. Anal Chem. 81(8):2969-75.