Prediploma Biochemistry, U Tübingen (D) 1984 Prediploma Chemistry, TU Munich (D) 1985 Diploma Chemistry, TU Munich (D) 1988 Dr. sc. nat ETH, ETH Zürich (CH) 1992 Habilitation, ETH Zürich (CH) 1998 Visiting scientist, U Auckland (NZ) 1988 Fellow of the Studienstiftung des Deutschen Volkes (1982-1988) Fellow im Verband der Chemischen Industrie (1989-1991) Awards: Medaille der ETH 1992 Research Innovation Award 1999, Research Corporation Buck-Whitney Medal 2003 of the ACS Scientific American 50 Award 2003 for “Chemistry and Materials” Laukien Prize 2006 2007 SUNY Chancellor’s Award for Excellence in Scholarship and Creative Activities

Medicinal Chemistry and Chemical Biology/Physical Chemistry/

Our research focuses on:

Development of Bio-NMR methods for structural genomics. Our group participates in the Northeast Structural Genomics Consortium (NESG). High-throughput NMR structure determination is supported by the Center for Computational Research. Structure determinations of biological macromolecules using nuclear magnetic resonance (NMR) spectroscopy. Development of NMR-based structural biology in supercooled water. Investigation of cellular metabolism in support of biotechnology research. Metabonomics NMR Instrumentation:

Primary User: Varian 600 and 750 MHz spectrometers (cryogenic probes) Access to: 500 (nanoprobe), 500 (1H/ 19F/ 13C/ 15N/ 2H-probe), 400, 300 MHz spectrometers

"Atreya, H.S., Sathyamoorthy, B., Jaipuria, G., Beaumont, V., Varani, G., *Szyperski, T. (2012) GFT Projection NMR for Efficient (1)H/(13)C Sugar Spin System Identification in Nucleic Acids. J. Biomol. NMR 54:337-342. PMID:23192291 [PubMed in progress]

Manning, K.A., Sathyamoorthy, B., Eletsky, A., Szyperski, T., Murkin, A.S. (2012) Highly Precise Measurement of Kinetic Isotope Effects Using 1H-Detected 2D [13C,1H]-HSQC NMR Spectroscopy. J. Am. Chem. Soc. 134:20589-20592. PMID:23215000

Sathyamoorthy, B., Singarapu, K.K., Garcia, A.E., *Szyperski, T. (2013) Protein Conformational Space Populated in Solution Probed with Aromatic Residual Dipolar (13)C-(1)H Couplings. ChemBioChem 14:684-688. PMID:23494854

Pulavarti, S.V., He, Y., Feldmann, E.A., Eletsky, A., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Kennedy, M.A., *Szyperski, T. (2013) Solution NMR Structures Provide First Structural Coverage of the Large Protein Domain Family PF08369 and Complementary Structural Coverage of Dark Protochlorophyllide Oxidoreductase Complexes. J. Struct. Funct. Genomics 14: 119-126. PMID: 23963952

Pulavarti, S.V., Eletsky, A., Lee, H.W., Acton, T.B., Xiao, R., Everett, J.K., Prestegard, J.H., Montelione, G.T., *Szyperski, T. (2013) Solution NMR structure of CD1104D from Pathogenic Clostridium Difficile Reveals a Distinct a-Helical Architecture and Provides First Structural Representative of Protein Domain Family PF14203. J. Struct. Funct. Genomics 14: 155-160. PMID:24048810

Stark, J.L., Copeland, J.C., Eletsky, A., Somerville, G.A., Szyperski, T., Powers, R. (2014) Identification of Low-molecular-weight Compounds Inhibiting Growth of Corynebacteria: Potential Lead Compounds for Anitibiotics. ChemMedChem 9:282-285. PMID:2440305

Muppidi, A., Doi, K., Edwardraja, S., Pulavarti, S.V., Szyperski, T., Wang, H.G., Lin, Q. (2014) Targeted Delivery of Ubiquitin-conjugated BH3 Peptide-based Mcl-1 Inhibitors into Cancer Cells. Bioconj. Chem. 24:424-432. PMID:24410055

Pulavarti, S.V., Eletsky, A., Huang, Y.J., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., *Szyperski, T. (2014) Polypeptide Backbone, Cb and Methyl Group Resonance Assignments of the 24 kDa Plectin Repeat Domain 6 from Human Protein Plectin. J. Biomol. NMR Assign. [Epub ahead of print]. PMID: 24722902

Sathyamoorthy, B., Parish, D.M., Montelione, G.T., Xiao, R., *Szyperski, T. (2014) Spatially Selective Heteronuclear Multiple-quantum (HMQC) Spectroscopy for Bio-molecular Studies. ChemPhysChem [Epub ahead of print]. PMID:24789578

Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., *Szyperski, T. (2014) High-quality NMR Structure of Human Anti-apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design. PLoS One 9:e96521. PMID:24789074