B.S., University of California, Irvine, 1985 M.S., California State University, Long Beach, 1989 Ph.D., University of California, Riverside, 1993 National Institutes of Health Postdoctoral Fellow, University of Pennsylvania, 1993-96

ORGANIC CHEMISTRY

Our primary interest lies in the field of chemical synthesis. Within this discipline, we are particularly facinated by the interplay between structure (biological activity), total synthesis, and reaction development.

Orendt, A. M.; Roberts, S. W.; Rainier, J. D. "The Role of Asynchronous Bond Formation in the Diastereoselective Epoxidation of Cyclic Enol Ethers: A Density Functional Theory Study," J. Org. Chem. 2006, 71, 5565. Sabahi, A.; Novikov, A.; Rainier, J. D. "2-Thioindoles as Precursors to Spiro-Fused Indolines: Synthesis of (??)-Dehaloperophoramidine,"Angew. Chem. Int. Ed. 2006, 45, 4317. Majumder, U.; Cox, J. M.; Johnson, H. W. B.; Rainier, J. D. "The Total Synthesis of Gambierol. The Generation of the A-C and F-H Subunits Using a C-Glycoside Centered Strategy," Chem. Eur. J. 2006, 12, 1736. Johnson, H. W. B.; Majumder, U.; Rainier, J. D. "The Total Synthesis of Gambierol. Subunit Coupling and Completion," Chem. Eur. J. 2006, 12, 1747. Liu, Z.; Rainier, J. D. "Ring-Opening/ring-Closing Metathesis (RORCM) Reactions of 7-Azanorbornene Derivatives. An Entry into Perhydroindolines," Org. Lett. 2006, 8, 459. Majumder, U.; Rainier, J. D. "Olefinic-ester cyclizations using Takai-Utimoto reduced titanium alkylidenes," Tetrahedron Lett. 2005, 46, 7209. Roberts, S. W.; Rainier, J. D. Substitution and Remote Protecting Group Influence on the Oxidation/Addition of a-Substituted 1,2-Anhydroglycosides: A Novel Entry into C-Ketosides," Org. Lett. 2005, 7, 1141. Johnson, H. W. B.; Majumder, U.; Rainier, J. D.* "The Total Synthesis of Gambierol," J. Am. Chem. Soc. 2005, 127, 848. Liu, Z.; Rainier, J. D. "Regioselective Ring-Opening/Cross-Metathesis Reactions of Norbornene Derivatives with Electron Rich Olefins," Org. Lett. 2005, 7, 131.

Nyong, A.; Rainier, J. D. "The diastereoselective synthesis of quaternary substituted thioindolines from sulfur ylide intermediates, J. Org. Chem. 2005, 70, 746..