Education B.S. 1986 Depatment of Industrial Chemistry, Facultyof Engineering Kyoto University (Prof.K. Utimoto) Ph. D. 1991 from Kyoto University (Directed by Prof.K. Utimoto) Thesis title "Studieson Triethylborane Induced Radical Reactions with Hydrides of Group14 Elements" During Ph.D study, 1988-1989 exchange student at UC Berkeley (Directed by Prof. C. H.Heathcock) "Studies on the Stereo-controlin the Synthesis of Acyclic Compounds" Professional Career 1991–1999 Instructor of Kyoto University 1999–2002 Associate Professor of Kyoto University 2000–2003 Researcher of PRESTO, JST 2002–2003 Associate Professor of The University of Tokyo 2003– Professor of The University of Tokyo (current position) Academic Activity 1997– International Symposium on Homogeneous Catalysis (ISHC) International Advisory Board 2003– Journal of Polymer Science Part A: Polymer Chemistry (Wiley) Editorial Board 2003–2006 Dalton Transactions (RSC) International Advisory Board 2003– Green Chemistry (RSC) Advisory Board 2008–2013 Journal of the American Chemical Society (ACS) Editorial Advisory Board 2009–2014 Organometallics (ACS) Editorial Advisory Board 2009–2016 ChemCatChem (Wiley) Editorial Board 2010– Chemical Science (RSC) Advisory Board 2011–2013 Inorganic Chemistry (ACS) Editorial Advisory Board 2011–2015 Catalysis Science & Technology (RSC) Advisory Board 2014–2021 Angewandte Chemie International Edition (Wiley) International Advisory Board 2015– Chemistry Letters (CSJ) Senior Editor 2018– Chemical Reviews (ACS) Editorial Advisory Board 2018– Macromolecules (ACS) Editorial Advisory Board 2018– Chemistry – An Asian Journal (Wiley) International Advisory Board 2019– Materials Chemistry Frontiers (RSC) Advisory Board 2019– Polymer Chemistry (RSC) Advisory Board

Asymmetric Synthesis Using Chiral Transitionmetal Complexes as Catalysts Development of New Organic Transformations Mediated by Organometallic Compounds

Bimetallic synergy in supported Ni–Pd catalyst for selective hydrogenolysis of C–O bonds in epoxy resins. Y. Huang, Y. Yamazaki, K. Nomoto, H. Miura, T. Shishido, X. Jin, K. Nozaki. Nat. Commun. 2025, 16, 1188. 10.1038/s41467-025-56488-4 Highlighted in Press release (東京大学工学部、JST), Bioengineer.org, ScienMag, EurekAlert!, Phys.org, ScienceDaily, 日本経済新聞.. ChemRxiv 2024 (preprint) 10.26434/chemrxiv-2024-lncxh High Carbon Recovery in Photocatalytic Degradation of High-Density Polyethylene (HDPE): Blend with Stearic Acid as a Radical Source. B. Lu, K. Takahashi, K. Nozaki. ACS Macro Lett. 2025, 14, 231–234. 10.1021/acsmacrolett.4c00726 Molecular Insight into Hydrodeoxygenation of Naphthols: Iridium-Catalyzed Ring Hydrogenation and Substrate-Catalyzed Dehydration. C. Sant Gjermestad, S. Kusumoto, I. Flores-Linares, G. Occhipinti, E. Le Roux, H. Ando, K. Nozaki, V. Jensen. Organometallics 2025, 44, 536–546. 10.1021/acs.organomet.4c00462 Electrochemical Conversion of Carboxylic Acids to Terminal Alkenes Enabled by Dialkyl Phosphate Electrolyte. T. Ito, X. Jin, K. Nozaki. ChemRxiv 2024 (preprint) 10.26434/chemrxiv-2024-hnsv9 Degradation of Epoxy Resins in Water for Recovery of Small Organic Molecules: The Use of Platinum Catalyst under Hydrothermal Conditions. K. Nozaki, Y. Liao, S. Hosokawa, K. Takahashi, S. Nakagawa, N. Yoshie, Y. Yamasaki. Research Square 2024 (preprint) 10.21203/rs.3.rs-5298299/v1 Exceptionally Short Tetracoordinated Carbon–Halogen Bonds in Hexafluorodihalocubanes. M. Sugiyama, Y. Uetake, N. Miyagi, M. Yoshida, K. Nozaki, T. Okazoe, M. Akiyama. J. Am. Chem. Soc. 2024, 146, 30686–30697. 10.1021/jacs.4c12732 Highlighted in ChemistryViews. Sequence-Controlled Copolymerization of Structurally Well-Defined Multinuclear Zinc Acrylate Complexes and Styrene. T. Iwasaki, G. Suehisa, R. Mandai, K. Nozaki. Macromol. Rapid Commun. 2025, 46, 2400742. 10.1002/marc.202400742 Crystallization of Strictly Linear Poly(ethylene-ran-acrylic acid) Copolymer: Impacts of Pendant Group Insertion and Hydrogen Bonding. J. Zhou, K. Takahashi, K. Nozaki, Y. Yamamoto, T. Katashima, N. Yoshie, S. Nakagawa. Macromolecules 2024, 57, 10176–10191. acs.macromol.4c01250 Synthesis, Structure, and Optical Property of Tris(biaryldiyl)metal Complexes Consisting of Group 9 Elements. M. Hara, Y. Hirooka, T. Iwasaki, K. Nozaki. Inorg. Chem. 2024, 63, 21474–21487. 10.1021/acs.inorgchem.4c03514 Fully Conjugated Tetraborylethylene: Selenium Mediated C–C Double Bond Formation from Diborylcarbenoid. Y. Shibutani, S. Kusumoto, K. Nozaki. Chem. Sci. 2024, 15, 17912–17917. 10.1039/D4SC05928J Synthesis, Structure, and Optical Property of [6]Cyclo-1,2-naphthylene. M. Hara, N. Toriumi, M. Uchiyama, K. Nozaki. Chem. Eur. J. 2024, 30, e202402323. 10.1002/chem.202402323 Highlighted in ChemistryViews, Synfacts. Bimetallic Synergy in Ru−Pt Alloy Catalyst for Polyethylene Hydrogenolysis. Y. Yamazaki, X. Jin, W. Sun, K. Nomoto, K. Takahashi, H. Miura, T. Shishido, A. Nakayama, K. Nozaki. ChemRxiv 2024 (preprint) 10.26434/chemrxiv-2024-sm1lp Polyethylene Materials with Tunable Degradability by Incorporating In-chain Mechanophores. X. Zhang, Y. Zhao, M. Chen, M. Ji, Y. Sha, K. Nozaki, S. Tang. J. Am. Chem. Soc. 2024, 146, 24024–24032. 10.1021/jacs.4c07445 Pd-Catalyzed Thiotritylation Cross-Coupling of Aryl Bromides and Iodides to Access Sulfur Functional Groups. Y. Liu, T. Okazoe, T. Gatzenmeier, K. Nozaki. ChemistryEurope 2024, 2, e202400053. 10.1002/ceur.202400053 Chemoselective Hydrogenolysis of Urethanes to Formamides and Alcohols in the Presence of More Electrophilic Carbonyl Compounds. T. Iwasaki, Y. Yamada, N. Naito, K. Nozaki. J. Am. Chem. Soc. 2024, 146, 25562–25568. 10.1021/jacs.4c06553 Highlighted in Press Release, 日刊工業新聞, 日本経済新聞, ニュースイッチ, fabcross forエンジニア, Chem-Stationスポットライトリサーチ, マイナビニュース, Mapion, Science Portal. Featured on the supplementary cover.. ChemRxiv 2024 (preprint) 10.26434/chemrxiv-2024-69jc4 Aliphatic Polyketones from Alternating Copolymerization of CO and Olefins: Phosphinoamidate Nickel Catalyst, Polymerization Study, Mechanical Properties and Degradations. L. Zhu, J. Li, W. -Y. Chen, C. Ziegler, K. Takahashi, K. Nozaki, L. Jia. ACS Appl. Polym. Mater. 2024, 6, 9829–9836. 10.1021/acsapm.4c01691 Stability of Medium-Ring Cyclic Unsaturated Carbonyl Compounds. Direct Access to Unsaturated Ketones with C−C Double Bond at Distal Positions via Transfer Dehydrogenation of Alicyclic Ketones. M. Iwasaki, S. Kusumoto, K. Nozaki. Org. Lett. 2024, 26, 6540–6545. 10.1021/acs.orglett.4c01971 Synthesis of Long-Chain Polyamides via Main-Chain Modification of Polyethyleneketones. Y. Lu, K. Takahashi, J. Zhou, R. Nontarin, S. Nakagawa, N. Yoshie, K. Nozaki. Angew. Chem. Int. Ed. 2024, 63, e202410849. 10.1002/anie.202410849 Mild Catalytic Degradation of Crystalline Polyethylene Units in Solid State Assisted by Carboxylic Acid Groups. B. Lu, K. Takahashi, J. Zhou, S. Nakagawa, Y. Yamamoto, T. Katashima, N. Yoshie, K. Nozaki. J. Am. Chem. Soc. 2024, 146, 19599–19608. 10.1021/jacs.4c07458 Highlighted in Press Release, 日本経済新聞. Synthesis of novel polymers with biodegradability by main-chain editing of chiral polyketones. H. Yuan, K. Takahashi, S. Hayashi, M. Suzuki, N. Fujikake, K. Kasuya, J. Zhou, S. Nakagawa, N. Yoshie, C. Li, K. Yamaguchi, K. Nozaki. J. Am. Chem. Soc. 2024, 146, 13658–13665. 10.1021/jacs.4c04389 Highlighted in Press Release.. ChemRxiv 2023 (preprint) 10.26434/chemrxiv-2023-wj0p6 Hydrogenolysis of Urethanes and Ureas Catalyzed by Manganese Complex Supported by Bidentate PN Ligand. T. Iwasaki, N. Saito, Y. Yamada, S. Ajiro, K. Nozaki. Organometallics 2024, 43, 924–928. 10.1021/acs.organomet.4c00032 Tetrakispyrazolylethene: Protonation-Induced Emission. Y. Takemasa, K. Nozaki. J. Org. Chem. 2024, 89, 7156–7162. 10.1021/acs.joc.4c00538 Linear, Planar, Orbicular, and Macrocyclic Multinuclear Zinc (Meth)acrylate Complexes. T. Iwasaki, G. Suehisa, H. Tadaoka, K. Shiga, K. Nozaki. Chem. Eur. J. 2024, 30, e202400586. 10.1002/chem.202400586 Selective Hydrogenation of Aldehydes Under Syngas Using CeO2-Supported Au Nanoparticle Catalyst. K. Shirayama, X. Jin, K. Nozaki. J. Am. Chem. Soc. 2024, 146, 14086–14094. 10.1021/jacs.4c02531 Featured on the supplementary cover. Highlighted in Synfacts. Hydrogen-induced formation of surface acid sites on Pt/Al(PO3)3 enables remarkably efficient hydrogenolysis of C−O bonds in alcohols and ethers. K. Oshida, K. Yuan, Y. Yamazaki, R. Tsukimura, H. Nishio, K. Nomoto, H. Miura, T. Shishido, X. Jin, K. Nozaki. Angew. Chem. Int. Ed. 2024, 63, e202403092. 10.1002/anie.202403092 Highlighted in Synfacts.. ChemRxiv 2023 (preprint) 10.26434/chemrxiv-2023-vjn0d Hexakispyrazolylethane: New Strategy for Stabilization of Hexaarylethane. Y. Takemasa, K. Nozaki. Chem. Eur. J. 2024, 30, e202303575. 10.1002/chem.202303575 Highlighted in Synfacts. Hydrogenative Degradation of PEG-Functionalized Lignin. S. Kusumoto, T. Higashi, Y. Matsumoto, T. Yamada, K. Nozaki. Polym. J. 2024, 56, 353–357. 10.1038/s41428-023-00867-5 Nickel-Catalyzed C(sp3)−O Hydrogenolysis via a Remote Concerted Oxidative Addition and its Application to Degradation of a Bisphenol A-Based Epoxy Resin. Y. Liao, K. Takahashi, K. Nozaki. J. Am. Chem. Soc. 2024, 146, 2419–2425. 10.1021/jacs.3c09061 Featured on the cover. Highlighted in OPR&D.. ChemRxiv 2023 (preprint) 10.26434/chemrxiv-2023-dz9v9-v2 Fluoroalkylated Hypervalent Sulfur Fluorides: Radical Addition of Arylchlorotetrafluoro-λ6-sulfanes to Tetrafluoroethylene. E. Yasuo, K. Aikawa, K. Nozaki, T. Okazoe. Chem. Sci. 2023, 14, 12379–12385. 10.1039/D3SC04837C Difluorination of Heterobenzylic C–H Bonds with N-Fluoro-N-(fluorosulfonyl)carbamate (NFC). A. Adachi, T. Hashimoto, K. Aikawa, K. Nozaki, T. Okazoe. Org. Chem. Front. 2023, 10, 5362–5368. 10.1039/D3QO01162C Boron Polycation Supported by Cyclic Bis(carbodiphosphorane). K. Saito, S. Kusumoto, K. Nozaki. Chem. Eur. J. 2023, 29, e202302060. 10.1002/chem.202302060 A Dinuclear Rh(-I)/Rh(I) Complex Bridged by Biphilic Phosphinine Ligands. K. Masada, K. Okabe, S. Kusumoto, K. Nozaki. Chem. Sci. 2023, 14, 8524–8530. 10.1039/D3SC02292G Synthesis, Characterization and Trapping of a Cyclic Diborylcarbene, an Electrophilic Carbene. Y. Shibutani, S. Kusumoto, K. Nozaki. J. Am. Chem. Soc. 2023, 145, 16186–16192. 10.1021/jacs.3c04933 Featured on the cover. Highlighted in Chem-Station. N-Fluorobenzenesulfonimide (NFSI) analogs with deprotectable substituents: synthesis of β-fluoroamines via catalytic aminofluorination of styrenes. Y. Ito, A. Adachi, K. Aikawa, K. Nozaki, T. Okazoe. Chem. Commun. 2023, 59, 9195–9198. 10.1039/D3CC02292G Palladium-catalyzed copolymerization of ethylene or propylene with norbornene carboxylic acids and their esters. K. Tsuge, K. Lau, Y. Hirooka, T. Iwasaki, K. Yokomizo, K. Nozaki. Polymer 2023, 281, 126116. 10.1016/j.polymer.2023.126116 Chemoselectivity Change in Catalytic Hydrogenolysis enabling Urea-reduction to Formamide/Amine over More Reactive Carbonyl Compounds. T. Iwasaki, K. Tsuge, N. Naito, K. Nozaki. Nat. Commun. 2023, 14, 3279. 10.1038/s41467-023-38997-2 Highlighted in 日本経済新聞, 化学工業日報, Press Release, ASCII, Science Portal, Yahoo!ニュース.. ChemRxiv 2023 (preprint) 10.26434/chemrxiv-2023-z49zw Nickel-Catalyzed Selective Incorporation of Isolated In-Chain Carbonyls into Ethylene/Carbon Monoxide Copolymer Using Metal Carbonyls as a Carbonyl Source. G. Yonezaki, F. Seidel, K. Takahashi, K. Nozaki. Bull. Chem. Soc. Jpn. 2023, 96, 545–549. 10.1246/bcsj.20230073 Selected as a Selected Paper. Featured on Back Cover Picture. Cyclopentadienone Vanadium(I) Complex; Synthesis, Red-Ox Activity and Application to Catalytic Transfer Hydrogenation. T. Higashi, S. Kusumoto, K. Nozaki. Organometallics 2023, 42, 865–870. 10.1021/acs.organomet.3c00135 Structure and Reactivity of Ag(I) Complexes Bearing Tridentate Phosphinine Ligands. K. Masada, S. Kusumoto, K. Nozaki. Organometallics 2023, 42, 971–981. 10.1021/acs.organomet.3c00143 Multifunctional WO3−ZrO2-supported Platinum Catalyst for Remarkably Efficient Hydrogenolysis of Esters to Alkanes. K. Yuan, Y. Yamazaki, X. Jin, K. Nozaki. J. Am. Chem. Soc. 2023, 145, 3454–3461. 10.1021/jacs.2c11145 Featured on the supplementary cover. Highlighted in Synfacts. Chain Transfer Approach for Terminal Functionalization of Alternating Copolymerization of CO2 and Epoxide by Using Active Methylene Compounds as Chain Transfer Agents. H. Nagae, S. Akebi, S. Matsushiro, K. Sakamoto, T. Iwasaki, K. Nozaki, K. Mashima. Macromolecules 2022, 55, 9066–9073. 10.1021/acs.macromol.2c01761 TEMPO as a Hydrogen Atom Transfer Catalyst for Aerobic Dehydrogenation of Activated Alkanes to Alkenes. T. Ito, F. Seidel, X. Jin, K. Nozaki. J. Org. Chem. 2022, 87, 12733–12740. 10.1021/acs.joc.2c01302 Selected as Most Read Articles in September 2022. Electron in a cube: Synthesis and characterization of perfluorocubane as an electron acceptor. M. Sugiyama, M. Akiyama, Y. Yonezawa, K. Komaguchi, M. Higashi, K. Nozaki, T. Okazoe. Science 2022, 377, 756–759. 10.1126/science.abq0516 Pincer-Supported Perfluororhodacyclopentanes: High Nucleophilicity of M–CF Bond. S. Hayashi, T. Murayama, S. Kusumoto, K. Nozaki. Angew. Chem. Int. Ed. 2022, 61, e202207760. 10.1002/anie.202207760 Mechanistic Insight into Rh-Catalyzed C(sp2)–O Bond Cleavage Applied to Cross-Coupling Reaction of Benzofurans with Aryl Grignard Reagents. T. Iwasaki, W. Ishiga, S. Pal, K. Nozaki, N. Kambe. ACS Catal. 2022, 12, 7936–7949. 10.1021/acscatal.2c01974 Cationic and Neutral Iridium(III) Hydride Complexes Supported by a Rigid, Bidentate Boryl/Phosphine Ligand. F. Seidel, K. Nozaki. Organometallics 2022, 41, 1063–1066. 10.1021/acs.organomet.2c00126 Incorporation of CO2-derived Bicyclic Lactone into Conventional Vinyl Polymers. M. Hill, S. Tang, K. Masada, Y. Hirooka, K. Nozaki. Macromolecules 2022, 55, 3311–3316. 10.1021/acs.macromol.1c02503 Statistical Analysis of Catalytic Performance in Ethylene/Methyl Acrylate Copolymerization Using Palladium/Phosphine–Sulfonate Catalysts. S. Akita, J -Y. Guo, F. Seidel, M. Sigman, K. Nozaki. Organometallics 2022, 41, 3185–3196. 10.1021/acs.organomet.2c00066 Synthesis of Crystalline CF3-Rich Perfluoropolyethers from Hexafluoropropylene Oxide and (Trifluoromethyl)Trimethylsilane. M. Koyama. M. Akiyama, K. Kashiwagi, K. Nozaki, T. Okazoe. Macromol. Rapid Commun. 2022, 43, 2200038. 10.1002/marc.202200038 Synthesis and Reactivity of PC(sp3)P-pincer Iridium Complexes Bearing Diborylmethyl Anion. M. Kishino, S. Takaoka, Y. Shibutani, S. Kusumoto, K. Nozaki. Dalton Trans. 2022, 51, 5009–5015. 10.1039/D2DT00513A Atom Swapping on Aromatic Rings: Conversion from Phosphinine Pincer Metal Complexes to Metallabenzenes Triggered by O2 Oxidation. K. Masada, S. Kusumoto, K. Nozaki. Angew. Chem. Int. Ed. 2022, 61, e202117096. 10.1002/anie.202117096 Featured on the cover. Cleavage of Si–H, Si–C Bonds by Metal–Ligand Cooperation: Formation of Silyl Anion and Silylene Equivalents from Tertiary Silanes. T. Higashi, S. Kusumoto, K. Nozaki. Organometallics 2022, 41, 659–665. 10.1021/acs.organomet.2c00037 Selected as ACS Editors' Choice. Selected as Most Read Articles in 2022. A Ni0 σ-Borane Complex Bearing a Rigid Bidentate Borane/Phosphine Ligand: Boryl Complex Formation by Oxidative Dehydrochloroborylation and Catalytic Activity for Ethylene Polymerization. F. W. Seidel, K. Nozaki. Angew. Chem. Int. Ed. 2022, 62, e202111691. 10.1002/anie.202111691 Synthesis of Triptycenemonohydroquinonedibenzoquinone by Comproportionation. Y. Takemasa, K. Nozaki. J. Org. Chem. 2022, 87, 1502–1506. 10.1021/acs.joc.1c01683 Featured on the cover. Highly Active Cross Metathesis of Tetrafluoroethylene with a Seven-membered NHC-Ruthenium Catalyst. K. Mori, M. Akiyama, K. Inada, Y. Imamura, Y. Ishibashi, Y. Takahira, K. Nozaki, T. Okazoe. J. Am. Chem. Soc. 2021, 143, 20980–20987. 10.1021/jacs.1c10574 J. Am. Chem. Soc. 2021, 143, 20980–20987. 10.1021/jacs.1c10574 Highlighted in Synfact. Bench-Stable Electrophilic Fluorinating Reagents for Highly Selective Mono- and Difluorination of Silyl Enol Ethers. A. Adachi, K. Aikawa, Y. Ishibashi, K. Nozaki, T. Okazoe. Chem. Eur, J. 2021, 27, 11919–11925. 10.1002/chem.202101499 One-Pot Synthesis of Polyethylene-Based Block Copolymers via a Dual Polymerization Pathway. Y. Zhao, J. Jung, K. Nozaki. J. Am. Chem. Soc. 2021, 143, 18832–18837. 10.1021/jacs.1c08512 Accessing Divergent Main-Chain-Functionalized Polyethylenes via Copolymerization of Ethylene with a CO2/Butadiene-Derived Lactone. S. Tang, Y. Zhao, K. Nozaki. J. Am. Chem. Soc. 2021, 143, 17953–17957. 10.1021/jacs.1c08578 High Density Polyethylenes Bearing Isolated In-Chain Carbonyls. S. Tang, F. W. Seidel, K. Nozaki. Angew. Chem. Int. Ed. 2021, 60, 26506–26510. 10.1002/anie.202110957 Heterolytic Oxidative Addition of sp2 and sp3 C–H Bonds by Metal–Ligand Cooperation with an Electron-deficient Cyclopentadienone Iridium Complex. T. Higashi, S. Kusumoto, K. Nozaki. J. Am. Chem. Soc. 2021, 143, 12999–13004. 10.1021/jacs.1c06714 Featured on the cover. Lithium Hexaphenylrhodate(III) and –Iridate(III): Structure in the Solid State and in Solution. T. Iwasaki, Y. Hirooka, H. Takaya, T. Honma, K. Nozaki. Organometallics 2021, 40, 2489–2495. 10.1021/acs.organomet.1c00248 Metal-Ligand Cooperative κ1-N-pyrazolate Cp*RhIII-Catalysts for Dehydrogenation of Dimethylamine-borane at Room Temperature. S. Pal, T. Iwasaki, K. Nozaki. Dalton Trans. 2021, 50, 7938–7943. 10.1039/D1DT01705E Copolymerization of Ethylene and Methyl Acrylate by Palladium Catalysts Bearing IzQO Ligand Containing Methoxyethyl Ether Moiety and Salt Effect for the Polymerization. S. Akita, K. Nozaki. Polym. J. 2021, 53, 1057–1060. 10.1038/s41428-021-00500-3 Metal-Support Cooperation in Al(PO3)3-Supported Pt Nanoparticles for the Selective Hydrogenolysis of Phenols to Arenes. X. Jin, R. Tsukimura, T. Aihara, H. Miura, T. Shishido, K. Nozaki. Nat. Catal. 2021, 4, 312–321. 10.1038/s41929-021-00598-x See the article. Synthesis and Properties of Spiro-double Sila[7]helicene: The LUMO Spiro-conjugation. N. Terada, K. Uematsu, R. Higuchi, Y. Tokimaru, Y. Sato, K. Nakano, K. Nozaki. Chem. Eur. J. 2021, 27, 9342–9349. 10.1002/chem.202100385 Selected as Top Downloaded Article published in 2021. Reversible PtII-CH3 Deuteration without Methane Loss: Metal-Ligand Cooperation vs Ligand-Assisted PtII-Protonation. S. Pal, K. Nozaki, A. Vedernikov, J. Love. Chem. Sci. 2021, 12, 2960–2969. 10.1039/D0SC06518H Umpolung of B–H Bonds by Metal–Ligand Cooperation with Cyclopentadienone Iridium Complexes. T. Higashi, S. Kusumoto, K. Nozaki. Angew. Chem. Int. Ed. 2021, 60, 2844–2848. 10.1002/anie.202011322