Filo was born in Fivizzano, Italy, in 1987 and grew up in the small village of Serricciolo in Lunigiana, a beautiful land in the North of Tuscany. He received his M.Sc. degree in Pharmacy with summa cum laude from the Università degli Studi di Parma in 2011. During his years in Parma, Filo matured his passion for organic chemistry and in particular for complex molecule synthesis. He then moved to bonnie Scotland where he pursued his graduate studies working in Professor J. Stephen Clark’s group at the University of Glasgow and earned his Ph.D. in chemistry in 2015. His graduate research focused on the total synthesis of complex biologically active natural products including the amphidinolide T family of anti-cancer natural products, advanced fragments of anti-tumor agents amphidinolide C and F, and the A–D ring system of the anti-fungal gambieric acids, a family of complex polycyclic ether natural products. In the Summer of 2015, Filo decided to move across the pond and work as postdoctoral research associate in the group of Prof. Amir Hoveyda at Boston College. In January 2019, Prof. Hoveyda decided to establish a second research group in Strasbourg, France, and Filo was offered the position of Senior Research Associate to manage and supervise the European branch of the group. In his time in the Hoveyda group, he has focused on the development of practical and high-impact catalytic transformations for the facile and efficient synthesis of complex bioactive compounds. In June 2022, Filo returned to the USA as Assistant Professor in the Department of Chemistry and Biochemistry at the University of Texas at Dallas and CPRIT Scholar. Filo’s research focuses on the development of new synthesis logics and chemical methods for the efficient, scalable and concise synthesis of complex bioactive natural products and their analogs. Appointments 2022-Assistant Professor of Chemistry University of Texas at Dallas CPRIT Scholar 2019-2022 Senior Research Associate Supramolecular Science and Engineering Institute (ISIS),University of Strasbourg, France Advisor: Professor Amir H. Hoveyda 2015-2019 Postdoctoral Research Fellow Boston College Advisor: Professor Amir H. Hoveyda Education 2011-2015 Ph.D. in Chemistry University of Glasgow, Glasgow, United Kingdom Advisor: Professor J. Stephen Clark 2006-2011 M.Sc. Pharmacy Università degli Studi di Parma, Parma, Italy Advisors: Professors Giovanni Casiraghi and Franca Zanardi Awards CPRIT Recruitment of First-Time, Tenure-Track Faculty Members Award, 2022 University of Texas System Rising STARs Award, University of Texas System, 2022 3rd Year PhD Prize (Organic Section), 2014, University of Glasgow, Glasgow, UK 1st Year PhD Prize (Organic Section), 2012, University of Glasgow, Glasgow, UK

Our goal is to identify significant problems in chemistry that impact society and human health and develop practical and creative solutions. Complex biologically active molecules are the inspiration and driving force for our research. We seek to build high-impact, novel, and practical chemical transformations and creative synthesis strategies that allow rapid access to complex natural products with potential application in treating human diseases. Our target molecules are structurally complex, biologically active compounds that demand innovative solutions. We welcome the opportunities to develop novel and impactful chemical transformations that ultimately advance state-of-the-art organic chemistry. The synthesis routes we aim to develop are atom-, step- and redox-economical, practical, and scalable to prepare large quantities of the target molecules for biological testing minimizing costs, energy expenditure, and waste generation. It is equally important that our strategies are versatile to enable facile preparation of analogs for further investigating structure/activity relationships, metabolism, and target identification studies paving the way to future medicine development.

“Two-Phase Strategy for the Enantioselective Total Syntheses of Vallesamidine and the Schizozygane Alkaloids” Ramakrishna, G. V.; Latif, Z.; Romiti, F.* Manuscript Submitted. “Catalytic Prenyl Conjugate Additions for the Synthesis of Enantiomerically Enriched PPAPs” Ng, S.; Howshall, C.; Ho, T. N.; Mai, B. K.; Zhou, Y.; Qin, C.; Tee, K. Z.; Liu, P.*; Romiti, F.*; Hoveyda, A. H.* Science 2024, 386, 167−175. *co-corresponding authors [HTML] [PDF] “Click Processes Orthogonal to CuAAC and SuFEx Forge Selectively Modifiable Fluorescent Links” Paioti, P. H. S.; Lounsbury, K. E.; Romiti F.; Formica M.; Bauer, V.; Zandonella, C.; Hackey, M. E.; del Pozo, J.; Hoveyda, A. H.* Nat. Chem. 2024, 16, 426−436. “Streamlined Strategy for Scalable and Enantioselective Total Syntheses of the Eburnane Alkaloids” Ramakrishna, G. V.; Pop, L. P.; Latif, Z.; Suryadevara, H. K. V.; Santo, L.; Romiti, F.* J. Am. Chem. Soc. 2023, 145, 20062−20072. [HTML] [PDF] “Diastereo- and Enantioselective Synthesis of Compounds with a Trifluoromethyl- and Fluoro-Substituted Carbon Centre” Xu, S.; del Pozo, J.; Romiti, F.; Fu, Y.; Mai, B. K.; Morrison, R. J.; Lee, K.; Hu, S.; Koh, M. J.; Lee, J.; Li, X.; Liu, P.*; Hoveyda, A. H.* Nat. Chem. 2022, 14, 1459−1469. “Convergent Synthesis of the C115. “Convergent Synthesis of the C1–C29 Framework of Amphidinolide F” Romiti, F.; Decultot, L.; Clark, J. S.* J. Org. Chem. 2022, 87, 8126−8141. “E– and Z-Trisubstituted Macrocyclic Alkenes for Natural Product Synthesis and Skeletal Editing” Mu, Y.; Hartrampf, F. W. W.; Yu, E. C.; Lounsbury, K. E.; Schrock, R. R.; Romiti, F.*; Hoveyda, A. H.* Nat. Chem. 2022, 14, 640–649. *co-corresponding authors [HTML] [PDF] “Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers” del Pozo, J.§; Zhang, S.§; Romiti, F.§; Xu, S.; Conger, R. P.; Hoveyda, A. H. * J. Am. Chem. Soc. 2020, 142, 18200–18212. §These authors contributed equally “A Catalytic Approach for Enantioselective Synthesis of Homoallylic Alcohols Bearing a Z-Alkenyl Chloride. A Concise and Protecting Group-Free Synthesis of Mycothiazole” Morrison, R. J.; van der Mei, F. W.; Romiti, F.*; Hoveyda, A. H.* J. Am. Chem. Soc. 2020, 142, 436–447. *co-corresponding authors [HTML] [PDF] “Catalytic Enantioselective Conjugate Addition of Stereodefined Di- and Trisubstituted Alkenylaluminum Compounds to Acyclic Enones” McGrath, K. P.; Hubbell, A. K.; Zhou, Y.; Padín Santos, D.; Torker, S.; Romiti, F.*; Hoveyda, A. H.* Adv. Synth. Catal. 2020, 362, 370–375. Special Issue: Dedicated to Eric N. Jacobsen on the occasion of his 60th birthday. *co-corresponding authors [HTML] [PDF] “Catalytic Enantioselective Boryl and Silyl Substitution with Trifluoromethyl Alkenes: Scope, Utility, and Mechanistic Nuances of Cu–F ß-Elimination” Paioti, P. H. S.; del Pozo, J.; Mikus, M. S.; Lee, J.; Koh, M. J.; Romiti, F.; Torker, S.; Hoveyda, A. H.* J. Am. Chem. Soc. 2019, 141, 19917–19934. “Different Strategies for Designing Dual-Catalytic Enantioselective Processes: From Fully Cooperative to Non-cooperative Systems” Romiti, F.; del Pozo, J.; Paioti, P. H. S.; Gonsales, S. A.; Li, X.; Hartrampf, F. W. W.; Hoveyda, A. H.* J. Am. Chem. Soc. 2019, 141, 17952–17961. “Catalytic Enantioselective Synthesis of Allylic Boronates Bearing a Trisubstituted Alkenyl Fluoride and Related Derivatives” Akiyama, S. ; Kubota, K.; Mikus, M. S.; Paioti, P. H. S.; Romiti, F.; Liu, Q.; Zhou, Y.; Hoveyda, A. H.*; Ito, H.* Angew. Chem. Int. Ed. 2019, 58, 11998–12003. “Delayed Catalyst Function Enables Direct Enantioselective Conversion of Nitriles to NH2-Amines” Zhang, S.§; del Pozo, J.§; Romiti, F.§; Mu, Y.; Torker, S.; Hoveyda, A. H.* Science 2019, 364, 45–51. §These authors contributed equally “Catalytic Diastereo- and Enantioselective Additions of Versatile Allyl Groups to N–H Ketimines” H. Jang, F. Romiti, S. Torker, A. H. Hoveyda* Nat. Chem. 2017, 9, 1269–1275. “Kinetically Controlled E-selective Catalytic Olefin Metathesis” Nguyen, T. T.; Koh, M. J.; Shen, X.; Romiti, F.; Schrock, R. R.; Hoveyda, A. H.* Science 2016, 352, 569–575. “Synthesis of the A−D Ring System of the Gambieric Acids” Clark, J. S.*; Romiti, F.; Sieng, B.; Paterson, L.; Stewart, A.; Chaudhury, S.; Thomas, L. H. Org. Lett. 2015, 17, 4694–4697. “Synthesis of Cyclopropyl-Substituted Furans by Brønsted Acid Promoted Cascade Reactions” Clark, J. S.*; Romiti, F.; Hogg, K. F.; Hamid, M. H. S. A.; Richter, S. C.; Boyer, A.; Redman, J. C.; Farrugia, L. J. Angew. Chem. Int. Ed. 2015, 54, 5744–5747. “Total Syntheses of Amphidinolides T1, T3, and T4” Clark, J. S.*; Romiti, F. Angew. Chem. Int. Ed. 2013, 52, 10072–10075.