B.S. Indiana University-Purdue University Indianapolis (1999) Organic Chemist, Eli Lilly & Co., Indianapolis, IN (2000 – 2004) Ph.D. California Institute of Technology (2009) Kanel Foundation Predoctoral Fellow (2007 – 2009) Caltech Herbert Newby McCoy Award (2009) NIH/NIGMS Postdoctoral Fellow, Massachusetts Institute of Technology (2009 – 2010)

Chemical Biology/Organic

Research in the Chenoweth laboratory is grounded in organic chemistry and molecular recognition with applications to biological and materials problems. We synthesize molecules and study their properties and interactions for a broad range of applications in bioorganic and materials chemistry. We are particularly interested in the design and synthesis of new molecules that can modulate nucleic acid and protein structure. Additionally, we are equally interested in the synthesis of new materials with sensing and self-assembly properties.

Undergraduate students, graduate students, and postdoctoral researchers are exposed to a diverse array of topics including organic chemistry, synthesis, bioorganic chemistry, macromolecular structure (nucleic acids and proteins), biochemistry, and polymer chemistry.

Rarig, Robert-André F.; Tran, Mai N.; Chenoweth, David M.J. Am. Chem. Soc. 2013, 135, 9213–9219, ASAP. DOI: 10.1021/ja404737q

Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNAChenoweth, David M.; Meier, Jordan L.; Dervan, Peter B.Angew. Chem. Int. Ed. 2012, 52, 415-418. DOI: 10.1002/anie.201205775

DNA−CNT Nanowire Networks for DNA DetectionWeizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M.J. Am. Chem. Soc. 2011, 133, 3238–3241 DOI: 10.1021/ja109180d

Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding Chenoweth, David M.; Dervan, Peter B.J. Am. Chem. Soc. 2010, 132, 14521-14529. DOI: 10.1021/ja105068b

Selected to appear on the front cover of JACSHighlighted in Chemical and Engineering News, “Putting DNA in a Bind,” Sept. 27, 2010 Addressable Terminally-Linked DNA-CNT NanowiresWeizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M.J. Am. Chem. Soc. 2010, 132, 14009–14011. DOI: 10.1021/ja109180d

Regiospecific Synthesis of Au-Nanorod/SWCNT/Au-Nanorod HeterojunctionsWeizmann, Yossi; Lim, Jeewoo; Chenoweth, David M.; Swager, Timothy, M. Nano Lett. 2010, 10, 2466–2469. DOI: 10.1021/nl1008025

Cyclooctyne-based Reagents for Uncatalyzed Click Chemistry: A Computational SurveyChenoweth, Kimberly; Chenoweth, David M.; Goddard III, William A. Org. Biomol. Chem. 2009, 7, 5255–5258. DOI: 10.1039/B911482C

Oligomerization Route to DNA Binding Py-Im Polyamide MacrocyclesChenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. Org. Lett. 2009, 11, 3590–3593. DOI: 10.1021/ol901311m

Allosteric Modulation of DNA by Small MoleculesChenoweth, David M.; Dervan, Peter B. Proc. Natl. Acad. Sci. USA 2009, 106, 13175–13179. DOI: 10.1073/pnas.0906532106

Solution-Phase Synthesis of Pyrrole-Imidazole PolyamidesChenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. J. Am. Chem. Soc. 2009, 131, 7175–7181. DOI: 10.1021/ja901307m

Cyclic Pyrrole-Imidazole Polyamides Targeted to the Androgen Response ElementChenoweth, David M.; Harki, Daniel A.; Daniel A.; Phillips, John W.; Dose, Christian;Dervan, Peter B. J. Am. Chem. Soc. 2009, 131, 7182–7188. DOI: 10.1021/ja901309z

Lancifodilactone G: Insights about an Unusually Stable EnolChenoweth, David M.; Chenoweth, Kimberly; Goddard III, William A. J. Org. Chem. 2008, 73, 6853–6856. DOI: 10.1021/jo8012385

Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn UnitDose, Christian; Farkas, Michelle E.; Chenoweth, David M.; Dervan, Peter B. J. Am. Chem. Soc. 2008, 130, 6859-6866. DOI: 10.1021/ja800888d

Fluorescent Sequence-Specific dsDNA Binding OligomersChenoweth, David M.; Viger, Anne; Dervan, Peter B. J. Am. Chem. Soc. 2007, 129, 2216-2217. DOI: 10.1021/ja0682576

Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-k B binding inhibitionChenoweth, David M.; Poposki, Julie A.; Marques, Michael A.; Dervan, Peter B. Bioorg. Med. Chem. 2007, 15, 759-770. DOI: 10.1016/j.bmc.2006.10.051

Programmable Oligomers for Minor Groove DNA RecognitionDoss, Raymond M.; Marques, Michael M.; Foister, Shane; Chenoweth, David M.; Dervan, Peter B. J. Am. Chem. Soc. 2006, 128, 9074-9079. DOI: 10.1021/ja0621795

Selective, non-amino-acid allosteric potentiators of mGlu2 receptorsBritton, T.; Barda, D.; Hornback, W.; Jagdmann, G.E.; Henry, S.; Fichtner, M.; Wang, Z.Q.; Coleman, D.; Chenoweth, D.; Vaught, G.; Fivush, A.; Dressman, B.; White, R.; Milot, G.; Herr, R.J.; Burry, L.; Johnson, M.; Large, T.; Monn, J.; Schoepp, D. Neuropharmacology 2002, 43, 279.

Selective, non-amino acid allosteric mGlu2 receptor potentiators inhibit dural plasma protein extravasation; A potential role in the treatment of migraineJohnson, K.; Dieckman, D.; Britton, T.; Johnson, M.; Jagdmann, E.; Monn, J.; Barda, D.; Henry, S.; Chenoweth, D.; Coleman, D.; Schoepp, D. Neuropharmacology 2002, 43, 291.