Visiting Professor, SGC, Nuffield Department of Medicine; and Visiting Fellow, Magdalen College; Oxford University, 2013-2014. University of Washington, Seattle; Postdoctoral Fellow, 1995-1999. University of California, Los Angeles; Ph.D., 1995. University of California, Davis; B.S., 1990

Biochemistry & Chemical Biology

Understanding Human Disease using Structural and Chemical Biology

Orans, J., Johnson, M.D.L., Coggan, K.A., Sperlazza, J.R., Heiniger, R.W., Wolfgang, M.C., and Redinbo, M.R. (2009). Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences USA, 107, 1065-1070. Ortlund, E.A., Bridgham, J.T., Redinbo, M.R., and Thornton, J.W. (2007). Crystal structure of an ancient protein: evolution by conformational epistasis. Science, 317, 1544-1548. Lujan, S.A., Guogas, L.M., Ragonese, H., Matson, S.W., and Redinbo, M.R. (2007). Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proceedings of the National Academy of Sciences USA, 104, 12282-12287. Ortlund, E.A., Lee, Y., Solomon, I.H., Hager, J.M., Safi, R., Choi, Y., Guan, Z., Tripathy, A., Raetz, C.R.H., McDonnell, D.P., Moore, D.D., and Redinbo, M.R. (2005). Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural and Molecular Biology, 12, 357-363. Bencharit, S., Morton, C.L., Xue, Y., Potter, P.M. and Redinbo, M.R. (2003). Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nature Structural Biology, 10, 349-356. Lesher, D.-T.T., Pommier, Y., Stewart, L., and Redinbo, M.R. (2002). 8-oxoguanine rearranges the active site of human topoisomerase I. Proceedings of the National Academy of Sciences USA, 99, 12102-12107. Bencharit, S., Morton, C.L., Howard-Williams, E.L., Danks, M.K., Potter, P.M., and Redinbo, M.R. (2002). Structural insights into CPT-11 activation by mammalian carboxylesterases. Nature Structural Biology, 9, 337-342. Watkins, R.E., Wisely, G.B., Moore, L.B., Collins, J.L., Lambert, M.H., Williams, S.P., Willson, T.M., Kliewer, S.A., and Redinbo, M.R. (2001). The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science, 292, 2329-2333. Stewart, L., Redinbo, M.R., Qiu, X., Hol, W.G.J., and Champoux, J.J. (1998). A model for the mechanism of human topoisomerase I. Science, 279, 1534-1541. Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., and Hol, W.G.J. (1998). Crystal structures of human topoisomerase I

in covalent and non-covalent complexes with DNA. Science, 279, 1504-1513.