University of Pittsburgh, BS in Chemistry (2005); University of Wisconsin-Madison, PhD in Chemistry with Lloyd M. Smith (2009); Harvard University, Postdoctoral Fellow with George M. Whitesides (2010-2013)

Analytical/Biochemistry & Chemical Biology

Analytical Sensors, Surface Chemistry, Array Fabrication, 3D Cell Culture Systems, Molecular Recognition, Protein-DNA interactions, Synthetic Biology

J.M. Fox, K. Kang, W. Sherman, A. Heroux, M. Sastry, M. Baghbanzadeh, M.R. Lockett, and G.M. Whitesides (2015) Interactions between Hofmeister anions and the binding pocket of a protein, accepted. B. Mosadegh,* M.R. Lockett,* K.T. Minn, K.A. Simon, K. Gilbert, S. Hillier, D. Newsome, H. Li, A.B. Hall, D.M. Boucher, B.K. Eustace, and G.M. Whitesides (2015) A Paper-based invasion assay: Assessing the metastatic potential of cancer cells in gradients of oxygen, Biomaterials, 52 (1). 262-271. H.J. Yoon, K.C. Liao, M.R. Lockett, S.W. Kwok, M. Baghbanzadeh, and G.M. Whitesides (2014) Rectification in tunneling junctions: 2,2'-bipyridyl-terminated n-alkanethiolates, J. Am. Chem. Soc., 136 (49). 17155-17162. B. Mosadegh, B.E. Dabiri, M.R. Lockett, R. Derda, P. Campbell, K.K. Parker, and G.M. Whitesides (2014) Three-dimensional paper-based model for cardiac ischemia, Adv. Healthcare Mat., 3. 1036-1043. P.W. Snyder,* M.R. Lockett,* D.T. Moustakas, and G.M. Whitesides (2014) Is it the shape of the pocket, or the shape of water within the pocket?, Eur. J. Phys. Spec. Top., 223 (5). 853-891. B. Breiten,* M.R. Lockett,* W. Sherman, M. Al-Sayah, S. Fujita, H. Lange, C.M. Bowers, A. Heroux, G. Krilov, and G.M. Whitesides (2013) Water networks contribute to enthalpy/entropy compensation in protein-ligand binding, J. Am. Chem. Soc., 135 (41). 15579–15584. 
 R. Derda,* M.R. Lockett,* S.K.Y. Tang, R.C. Fuller, E.J. Maxwell, B. Breiten, C.A. Cuddemi, A. Ozdogan, and G.M. Whitesides (2013) Filter-based assay for E. coli in aqueous samples using bacteriophage-based amplification. Anal. Chem., 85 (15). 7213-7220.
 M.R. Lockett,* H. Lange,* B. Breiten,* A. Heroux, W. Sherman, D. Rappoport, P.O. Yau, P.W. Snyder, and G.M. Whitesides (2013) The binding of benzoarylsulfonamide ligands to human carbonic anhydrase is insensitive to formal fluorination of the ligand, Angew. Chem., Int. Ed., 52 (30). 7714-7717.
 M.R. Lockett, K.M. Mirica, C.R. Mace, R. Blackledge, and G.M. Whitesides (2013) Analysis of forensic evidence based on density with magnetic levitation, J. Forens. Sci., 58 (1). 40-45. A.H. Broderick, M.C.D. Carter, M.R. Lockett, L.M. Smith, and D.M. Lynn (2013) Fabrication of oligonucleotide and protein arrays on rigid and flexible surfaces coated with reactive polymer multilayers, ACS Appl. Mater. Interfaces, 5 (2). 351-359. K.A. Mirica, M.R. Lockett, P.W. Snyder, N.D. Shapiro, and G.M. Whitesides (2012) Selective precipitation and purification of monovalent proteins using oligovalent ligands and ammonium sulfate, Bioconj. Chem., 23 (2). 293-299. C.H. Wu, M.R. Lockett, L.M. Smith (2012) RNA gene assembly from DNA arrays, Angew. Chem., Int. Ed., 51 (19). 4628-4632. A.H. Broderick,* M.R. Lockett,* M.E. Buck, Y. Yuan, L.M. Smith, and D.M. Lynn (2012) Layer-by-layer assembled films for the in-situ synthesis of oligonucleotide arrays, Chem. Mater., 24 (5). 938-945.
 P.W. Snyder, J. Mecinovic, D.T. Moustakas, S.W. Thomas, M. Harder, E.T. Mack, M.R. Lockett, A. Heroux, W. Sherman, and G.M. Whitesides (2011) The origin of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase, Proc. Natl. Acad. Sci.U.S.A., 108 (44). 17889-17894. C.N. Olson, M.M. Galloway, G. Yu, C.J. Hedman, M.R. Lockett, T.P. Yoon, E.A. Stone, L.M. Smith,C.N. Olson, M.M. Galloway, G. Yu, C.J. Hedman, M.R. Lockett, T.P. Yoon, E.A. Stone, L.M. Smith, and F.N. Keutsch (2011) Hydroxycarboxylic acid-derived organosulfates: synthesis, stability and quantification in ambient aerosol, Environ. Sci. Technol., 45 (15). 6468-6474. M.R. Lockett and L.M. Smith (2010) Halogenation of carbon substrates for increased reactivity with alkenes, Langmuir, 26 (22). 16642-16646. M.R. Lockett and L.M. Smith (2010) The formation and stability of alkyl thiol monolayers on carbon substrates, J. Phys. Chem. C, 114 (29). 12635-12641. J.B. Mandir,* M.R. Lockett,* M.F. Phillips, H.T. Allawi, V.I. Lyamichev, and L.M. Smith (2009) Rapid Detection of RNA accessible sites by surface plasmon resonance detection of hybridization to DNA arrays, Anal. Chem., 81 (21). 8949-8956.
 M.R. Lockett and L.M. Smith (2009) Fabrication and Characterization of DNA Arrays Prepared on Carbon-on-Metal Substrates, Anal. Chem., 81 (15). 6429-64037. M.R. Lockett, D.V. Le, J.C. Carlisle, and L.M. Smith (2009) Acyl chloride-modified amorphous carbon substrates for the attachment of alcohol-, thiol-, and amine-containing molecules, Langmuir, 25 (9). 5120-5126. M.R. Lockett and L.M. Smith (2009) Attaching molecules to chlorinated and brominated amorphous carbon substrates via Grignard reactions, Langmuir, 29 (6). 3340-3343.

M.R. Lockett, M.R. Shortreed, and L.M. Smith (2008) Aldehyde terminated amorphous carbon surfaces for the fabrication of biomolecule arrays, Langmuir, 24 (17). 9198-9203.