•Member of the Institute of Medicine (2014) •Member of the National Academy of Sciences (2012) •Member of the National Academy of Engineering (2005) •Member of the American Academy of Arts and Sciences (2005) •Fellow, American Association for the Advancement of Science (AAAS) (2006)

Biochemistry & Chemical Biology/Materials/Polymers & Nanoscience

Applying lithographic techniques from the computer industry to design of new medicines & vaccines; Nanomedicine; Interventional oncology; Fluoropolymers: batteries, microfluidics, minimally adhesive surfaces; Medical devices; Colloid, surfactant and surface chemistry; Role of diversity in innovation; Entrepreneurship from research-intensive universities; Public and private partnerships.

"Continuous liquid interface production of 3D objects"; Tumbleston, J. R.; Shirvanyants, D.; Ermoshkin, N.; Janusziewicz, R.; Johnson, A. R.; Kelly, D.; Chen, K.; Pinschmidt, R.; Rolland, J. P.; Ermoshkin, A.; Samulski, E. T.; DeSimone, J. M. Science, 2015, doi:10.1126/science.aaa2397 "Evaluation of drug loading, pharmacokinetic behavior, and toxicity of a cisplatin-containing hydrogel nanoparticle"; Kai, M. P.; Keeler, A. W.; Perry, J. L.; Reuter, K. G.; Luft, J. C.; O’Neal, S. K.; Zamboni, W. C.; DeSimone, J. M. J. Control. Release 2015, 204, 70-77, doi:10.1016/j.jconrel.2015.03.001 "Local Iontophoretic Administration of Cytotoxic Therapies to Solid Tumors"; Byrne, J. D.; Jajja, M. R. N.; O’Neill, A. T.; Bickford, L. R.; Keeler, A. W.; Hyder, N.; Wagner, K.; Deal, A.; Little, R. E.; Moffitt, R. A.; Stack, C.; Nelson, M.; Brooks, C. R.; Lee, W.; Luft, J. C.; Napier, M. E.; Darr, D.; Anders, C. K.; Stack, R.; Tepper, J. E.; Wang, A. Z.; Zamboni, W. C.; Yeh, J. J.; DeSimone, J. M. Science Translational Medicine 2015, 7(273), doi: 10.1126/scitranslmed.3009951 "Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization"; Fromen, C. A.; Robbins, G. R.; Shen, T. W.; Kai, M. P.; Ting, J. P. Y.; DeSimone, J. M.; Proc. Nat. Acad. Sci., 2014, doi: 10.1073/pnas.1422923112 "Phase Behavior and Electrochemical Characterization of Blends of Perfluoropolyether, Poly(ethylene glycol), and a Lithium Salt"; Wong, D. H. C.; Vitale, A.; Devaux, D.; Taylor, A.; Pandya, A.; Hallinan, D. T.; Thelen, J. L.; Mecham, S. J.; Lux, S. F.; Lapides, A. M.; Resnick, P. R.; Meyer, T. J.; Kostecki, R. M.; Balsara, N. P.; DeSimone, J. M.; Chem. Mater., 2014, doi: 10.1021/cm504228a "The Role of Diversity in Commercializing Basic Science"; DeSimone, J. M.; Research-Technology Management, 2014, 57(6), 16-20. "Design of Asymmetric Particles Containing a Charged Interior and a Neutral Surface Charge: Comparative Study on in Vivo Circulation of Polyelectrolyte Microgels"; Chen, K.; Xu, J.; Luft, J. C.; Tian, S.; Raval, J. S.; DeSimone, J. M. J. Am. Chem. Soc., 2014, doi: 10.1021/ja503939n, 136, 9947-9952 "A versatile acid-labile linker for antibody–drug conjugates"; Finniss, M. C.; Chu, K. S.; Bowerman, C. J.; Luft, J. C.; Haroon, Z. A.; DeSimone, J. M. MedChemComm, 2014, doi: 10.1039/c4md00150h "Driving convergence with human diversity"; DeSimone, J. M.; Farrell, C. L.; Science Translational Medicine, 2014, (6)238ed11, 1-2. "Metronomic docetaxel in PRINT® nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer"; Gharpure, K. M.; Chu, K. S.; Bowerman, C. J.; Miyake, T.; Pradeep, S.; Mangala, S. L.; Han, H. D.; Rupaimoole, R.; Armaiz-Pena, G. N.; Rahhal, T. B.; Wu, S. Y.; Luft, J. C.; Napier, M. E.; Lopez-Berestein, G.; DeSimone, J. M.; Sood, A. K.; Molecular Cancer Therapeutics, 2014, doi:10.1158/1535-7163.MCT-13-0930. "Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity"; Chu, K. S.; Finniss, M. C.; Schorzman, A. N.; Kuijer J. L.; Luft, C. J.; Bowerman, C. J.; Napier, M. E.; Haroon, Z. A.; Zamboni, W. C.; DeSimone, J. M.; Nanoletters., 2014, 14(3), 1472-1476. (# of citations = 2) "Nonflammable Perfluoropolyether-based Electrolytes for Lithium Batteries"; Wong, D. H.C.; Thelen, J.; Fu, Y.; Devaux, D.; Pandya, A. A.; Battaglia, V.; Balsara, N. P.; DeSimone*, J. M.; Proc. Nat. Acad. Sci., 2014, doi: 10.1073/pnas.1314615111. (# of citations = 1) "Nanotechnology: An Enduring Bridge Between Engineering and Medicine"; Petrosko, S. H.; Fromen, C. A.; Auyeung, E.; DeSimone, J. M.; Mirkin, C. A. The Bridge: Linking Engineering and Society; National Academy of Engineering, 2013, pp. 7-15. (# of citations = 0) "RNA Replicon Delivery via Lipid-Complexed PRINT Protein Particles"; Xu, J.; Luft, J. C.; Yi, X.; Tian, S.; Owens, G.; Wang, J.; Johnson, A.; Berglund, P.; Smith, J.; Napier, M. E.; DeSimone, J. M. Molecular Pharmaceutics 2013, 10(9), 3366-3374. (# of citations = 3) "Nanoparticle Drug Loading as a Design Parameter to Improve Docetaxel Pharmacokinetics and Efficacy"; Chu, K. S.; Schorzman, A. N.; Finniss, M. C.; Bowerman, C. J.; Peng, L.; Luft, J. C.; Madden, A.; Wang, A. Z.; Zamboni, W. C.; DeSimone*, J. M. Biomaterials 2013, 34(33), 8424-8429. (# of citations = 5) "Rapidly–Dissolvable Microneedle Patches Via a Highly Scalable and Reproducible Soft Lithography Approach"; Moga, K. A.; Bickford, L. R.; Geil, R. D.; Dunn, S. S.; Pandya, A. A.; Wang, Y.; Fain, J. H.; Archuleta, C. F.; O’Neill, A. T. O.; DeSimone*, J. M. Advanced Materials 2013, 25(36), 5060-5066. (# of citations = 7) "Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles"; Morton, S. W.; Herlihy, K. P.; Shopsowitz, K. E.; Deng, Z. J.; Chu, K. S.; Bowerman, C. J.; DeSimone, J. M.; Hammond, P. T. Advanced Materials 2013, 25(34), 4707. (# of citations = 6) "Synthesis and Characterization of Monodisperse Uniformly Shaped Respirable Aerosols"; Fromen, C. A.; Shen, T. W.; Larus, A. E.; Mack, P.; Maynor, B. W.; Luft, J. C.; DeSimone, J. M. AIChE Journal 2013, 59(9), 3184-3194. (# of citations = 0) "Nanoparticle clearance is governed by Th1/Th2 immunity and strain background"; Jones, S. W.; Roberts, R. A.; Robbins, G. R.; Perry, J. L.; Kai, M. P.; Chen, K.; Bo, T.; Napier, M.; Ting, J.P.Y.; DeSimone, J. M.; Bear*, J. E. J. Clinical Investigation 2013, 123(7), 3061-3073. (# of citations = 16)

"Analysis of the Murine Immune Response to Pulmonary Delivery of Precisely Fabricated Nano- and Microscale Particles"; Roberts, R. A.; Shen, T.; Allen, I. C.; Hasan, W.; DeSimone*, J. M.; Ting*, J, P-Y. Plos One 2013, 8(4), e62115. (# of citations = 2)