Following his PhD in synthetic organic chemistry (total synthesis) under the supervision of Professor E. J. Thomas, Dr Anthony Green began postdoctoral research with Professor Nicholas Turner and Professor Sabine Flitsch based in the Manchester Institute of Biotechnology (MIB), working in the field of industrial biocatalysis. Professor Green worked as a postdoctoral research associate in the group of Professor Donald Hilvert at ETH (Zurich), before starting his independent research career in 2016 based in the MIB (Department of Chemistry) at the University of Manchester where he is a BBSRC David Phillips research fellow, a Professor in organic & biological chemistry and holder of an ERC Consolidator grant.

Florence J. Hardy, Matthew G. Quesne, Emilie F. Gérard, Jingming Zhao, Mary Ortmayer, Christopher J. Taylor, Hafiz S. Ali, Jeffrey W. Slater, Colin W. Levy, Derren J. Heyes, J. Martin Bollinger, Jr., Sam P. de Visser and Anthony P. Green* Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code. ACS Catal, 11584-11590, (2024) . Zachary Birch-Price, Florence J. Hardy, Thomas M. Lister, Anna R. Kohn and Anthony P. Green* Noncanonical Amino Acids in Biocatalysis. Chemical Reviews, (2024) . Amy E. Hutton, Jake Foster, James E. J. Sanders, Christopher J. Taylor, Stefan A Hoffmann, Yizhi Cai, Sarah L. Lovelock* and Anthony P. Green*, An Efficient Pyrrolysyl-tRNA synthetase for Economical Production of MeHis-containing Enzymes. Faraday Discuss., 252, 295-305, (2024) . Amy E. Hutton, Jake Foster, Rebecca Crawshaw, Florence J. Hardy, Linus O. Johannissen, Thomas M. Lister, Emilie F. Gérard, Zachary Birch-Price, Richard Obexer, Sam Hay, Anthony P. Green*, A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme. Nature Communications, 15, 1956, (2024) . Elizabeth L. Bell, Amy E. Hutton, Ashleigh J. Burke, Adam O’Connell, Amber Barry, Elaine O’Reilly,* Anthony P. Green,* Strategies for designing biocatalysts with new functions. Chem. Soc. Rev, 53, 2851-2862, (2024) Read Here. Adam O’Connell, Amber Barry, Ashleigh J. Burke, Amy E. Hutton, Elizabeth L. Bell, Anthony P. Green,* Elaine O’Reilly,* Biocatalysis: landmark discoveries and applications in chemical synthesis, Chem. Soc. Rev., 53, 2828-2850, (2024) . Jingming Zhao, Ying Zhuo, Daniel E. Diaz, Muralidharan Shanmugam, Abbey J. Telfer, Peter J. Lindley, Daniel Kracher, Takahiro Hayashi, Lisa S. Seibt, Florence J. Hardy, Oliver Manners, Tobias M. Hedison, Katherine A. Hollywood, Reynard Spiess, Kathleen M. Cain, Sofia Diaz-Moreno, Nigel S. Scrutton, Morten Tovborg, Paul H. Walton*, Derren J. Heyes*, Anthony P. Green*, Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase. J. Am. Chem. Soc., 145, 37, 20672–20682, (2023) . Zachary Birch-Price, Christopher J. Taylor, Mary Ortmayer, Anthony P. Green, Engineering Enzyme Activity Using an Expanded Amino Acid Alphabet. Protein Engineering, Design and Selection, 36, gzac013, (2023) . Emily Radley, John Davidson, Jake Foster, Richard Obexer, Elizabeth L. Bell*, Anthony P. Green* Engineering Enzymes For Environmental Sustainability. Angew. Chem., 62, e20230930, (2023) . Euan J. Hossack, Florence J. Hardy*, Anthony P. Green*, Building Enzymes through Design and Evolution. ACS Catalysis, 13, 12436-12444, (2023). . Indrek Kalvet, Mary Ortmayer, Jingming Zhao, Rebecca Crawshaw, Nathan M. Ennist, Colin Levy, Anindya Roy*, Anthony P. Green*, David Baker* Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site. J. Am. Chem. Soc., 145, 14307-14315, (2023) . Christopher J. Taylor, Florence J. Hardy, Ashleigh J. Burke, Riley M. Bednar, Ryan A. Mehl, Anthony P. Green*, Sarah L. Lovelock*, Engineering Mutually Orthogonal PylRS/tRNA Pairs for Dual Encoding of Functional Histidine Analogues. Protein Sci, 32, e4640, (2023) . Dr. Ashleigh J. Burke, Thomas M. Lister, Dr. James R. Marshall, Dr. Murray J. B. Brown, Dr. Richard Lloyd, Prof. Anthony P. Green*, Prof. Nicholas J. Turner*, Engineered Biocatalysts for Enantioselective Reductive Aminations of Cyclic Secondary Amines. ChemCatChem. e202300256, (2023) . Aoife Taylor, Shaowei Zhang, Linus O. Johannissen, Michiyo Sakuma, Robert S. Phillips, Anthony P. Green, Sam Hay, Derren J. Heyes, Nigel S. Scrutton, Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase. FEBS J., (2023). . Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J.B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green, A Designed Photoenzyme for Enantioselective [2+2]-Cycloadditions. Nature, 611, 709-714, (2022) . Elizabeth Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, S. Ramachandran, A. Tedstone, S. Haigh, A. Garforth, P. Day, Colin Levy, Michael Shaver, and Anthony P. Green, Directed Evolution of an Efficient and Thermostable PET Depolymerase. Nature Catalysis, 5, 673-681, (2022) . Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker, Donald Hilvert, Anthony P. Green, The Road to Fully Programmable Protein Catalysis. Nature, 606, 49-58, (2022) . Rebecca Crawshaw, Amy E. Crossley, Linus Johannissen, Ashleigh J. Burke, Sam Hay , Colin Levy, David Baker , Sarah L. Lovelock  and Anthony P. Green, Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction. Nature Chemistry , 14, 313-320, (2022) . Highlighted in Chemistry World. Nature Catalysis research highlight. Nature Chemistry News & Views. Ashleigh J. Burke, William R. Birmingham, Ying Zhuo, Thomas W. Thorpe, Bruna Zucoloto da Costa, Rebecca Crawshaw, Ian Rowles, James D. Finnigan, Carl Young, Gregory M. Holgate, Mark P. Muldowney, Simon J. Charnock, Sarah L. Lovelock*, Nicholas J. Turner*, Anthony P. Green*, An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir. J. Am. Chem. Soc., 144, 3761-3765, (2022) . Nature Research Highlight, ACS Editor’s choice, associated article in New Statesman, a prominent British political and cultural magazine ‘Democratising Medicine: Creating Fair Access to Medicines’ (in press) Elizabeth L. Bell, William Finnigan, Scott P. France, Anthony P. Green, Martin A. Hayes, Lorna J. Hepworth, Sarah L. Lovelock, Haruka Niikura, Sílvia Osuna, Elvira Romero, Katherine S. Ryan, Nicholas J. Turner and Sabine L. Flitsch, Biocatalysis. Nat Rev Methods Primers, 1, 46, (2021) . Mary Ortmayer, Florence J. Hardy, Matthew G. Quesne, Karl Fisher, Colin Levy, Derren J. Heyes, C. Richard A. Catlow, Sam P. de Visser, Stephen E. J. Rigby, Sam Hay, Anthony P. Green*, A non-canonical tryptophan analogue reveals an active site hydrogen bond controlling ferryl reactivity in a heme peroxidase. JACS Au.,1, 913, (2021) . Florence J. Hardy, Mary Ortmayer, Anthony P. Green, Claire E.M. Noble, J. L. Ross Anderson, Recent Advances in Understanding, Enhancing and Creating Heme Peroxidases, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, (2021) . Mary Ortmayer, Karl Fisher, Jaswir Basran, Emmanuel M. Wolde-Michael, Derren J. Heyes, Colin Levy, Sarah L. Lovelock, J. L. Ross Anderson, Emma L. Raven, Sam Hay, Stephen E. J. Rigby, Anthony P. Green*, Rewiring the ‘push-pull’ catalytic machinery of a haem enzyme using an expanded genetic code. ACS Catalysis, 10, 2735, (2020) . Jingming Zhao, Ashleigh J. Burke, Anthony P. Green, Enzymes with Non-Canonical Amino Acids. Curr. Opin. Chem. Biol. 55, 136, (2020) . Calvin W Z Lee, M Qadri E Mubarak, Anthony P Green, Sam P de Visser, How Does Replacement of the Axial Histidine Ligand in Cytochrome c Peroxidase by Nδ-Methyl Histidine Affect Its Properties and Functions? A Computational Study. Int. J. Mol. Sci., 21, 7133, (2020) . Giulia Paggiola , Nolwenn Derrien , Jonathan D. Moseley , Anthony Green , Sabine L. Flitsch , James H. Clark , Con Robert McElroy and Andrew J. Hunt, Application of bio-based solvents for biocatalysed synthesis of amides with Pseudomonas stutzeri lipase (PSL). Pure Appl. Chem, 92 (4), 579-586, (2020) . Ashleigh J. Burke, Sarah L. Lovelock, Amina Frese, Rebecca Crawshaw, Mary Ortmayer, Mark Dunstan, Colin Levy, Anthony P. Green, Design and Evolution of an Enzyme with a Non-Canonical Organocatalytic Mechanism. Nature, 570, 219, (2019) . Highlighted in C&E News. Aaron Debon, Moritz Pott, Richard Obexer, Anthony P. Green, Lukas Friedrich, Andrew D. Griffiths, Donald Hilvert, Ultrahigh-Throughput Screening Enables Efficient Single-Round Oxidase Remodeling. Nature Catalysis, 2, 740, (2019) Jin Xu, Anthony P. Green, Nicholas J. Turner, Chemoenzymatic Synthesis of Pyrazines and Pyrroles. Angew. Chem. Int. Ed. 57, 16760, (2018) . Takahiro Hayashi, Donald Hilvert, Anthony P. Green, Engineered Metalloenzymes with Non-Canonical Coordination Environments. Chem. Eur. J., 24, 11821, (2018) . Moritz Pott, Takahiro Hayashi, Takahiro Mori, Peer R. E. Mittl, Anthony P. Green*, Donald Hilvert*, A Non-Canonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold. J. Am. Chem. Soc., 140, 1535, (2018)