Postdoc National Institutes of Health 2009-2011 Postdoc Stanford University 2008-2009 Ph.D. Brown University 2004-2008 B.S. Nanjing University 1999-2003

Analytical Chemistry/Inorganic Chemistry/Organic Chemistry/Physical Chemistry/Biological Chemistry/Chemical Education/Computational/Theoretical Chemistry/Environmental/Atmospheric Chemistry/Materials Chemistry and Nanoscience

Our research focuses on the development and evaluation of metal-, polymer- or protein-based nanoparticles for imaging and therapy. The idea is to conceptualize the nanoparticles not as merely tiny aggregates of molecules but rather as platforms with large surface-to-volume ratios. By harnessing the well-developed surface chemistry, one can load a wide range of functionalities onto the particle surface. We adopt an interdisciplinary approach, taking advantage of the recent progress on peptide/protein/materials chemistry, bioconjugation, molecule imaging, cell/molecular biology as well as clinical medicine, and integrating these merits, with rational design, into nanoscale gadgets.

Zhao W, Cheng R, Lim SH, Miller JR, Zhang W, Tang W, Xie J, Mao L, Biocompatible and Label-Free Separation of Cancer Cells from Cell Culture Lines from White Blood Cells in Ferrofluids, Lab Chip, 2017 Chen H, Weizhong Z, Guizhi Z, Xie, J, Xiaoyuan C, Rethinking Cancer Nanotheranostics, Nature Reviews Materials, 2017; 2:1-18 Zhen Z, Tang W, Wang M, Zhou S, Wang H, Wu Z, Zhonglin H, Li Z, Liu L, Xie J, Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control, Nano Letters, 2017; 17(2):862-869 Wang GD, Chen H, Tang W, Lee D, Xie J, Gd and Eu Co-doped Nanoscale Metal-Organic Framework as A T1-T2 Dual-modal Contrast Agent for Magnetic Resonance Imaging, Tomography, 2016; 2(3):179-187 Wang GD, Nguyen HT, Cox PB, Wang L, Nagata K, Hao S, Wang A, Li S, Chen H, Xie J. X-Ray Induced Photodynamic Therapy: A Combination of Radiotherapy and Photodynamic Therapy. Theranostics, 2016; 6(13):2295-2305 Cao J, An H, Huang X, Fu G, Zhuang R, Zhu L, Xie J, Zhang F. Monitoring of the tumor response to nano-graphene oxide-mediated photothermal/photodynamic therapy by diffusion-weighted and BOLD MRI. Nanoscale. 2016; 19(8):10152-10159 Fu G, Lei Z, Yang K, Zhuang R, Xie J, Zhang F. Diffusion-weighted magnetic resonance imaging for therapy response monitoring and early treatment prediction of photothermal therapy. ACS App Materials&Interfaces . 2016; 8(8):5137-5147 Tang W, Zhen Z, Wang M, Wang H, Chuang Y-J, Zhang W, Wang GD, Todd T, Cowger T, Chen H, Liu L, Li Z, Xie Jin. Red Blood Cell-Facilitated Photodynamic Therapy for Cancer Treatment. Adv Func Mater. 2016; 26(11):1757-1768 Melemendis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP. Molecular Magnetic Resonance Imaging of Angiogenesis in vivo using Polyvalent Cyclic RGD-Iron Oxide Microparticle Conjugates. Theranostics. 2015; 5(5):515-29. Chen H, Wang GD, Sun X, Todd T, Zhang F, Xie J, Shen B. Mesoporous Silica as Nanoreactors to Prepare Gd-encapsulated Carbon Dots of Controllable Sizes and Magnetic Properties. Adv Func Mater. 2016. 26(22):3973-3982. Chen H, Wang GD, Chuang YJ, Zhen Z, Chen X, Biddinger P, Hao Z, Liu F, Shen B, Pan Z, Xie J. Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for in vivo Cancer Treatment. Nano Letter. 2015; 15(4):2249-56. Cowger T, Tang W, Zhen Z, Hu K, Rink DE, Todd T, Wang G, Zhang W, Chen H, Xie J. Casein coated Fe5C2 nanoparticles with superior r2 relaxivity for liver-specific magnetic resonance imaging. Theranostics. 2015; 5(11):1225-1232. Chen H, Wang GD, Tang W, Todd T, Zhen Z, Tsang C, Hekmatyar K, Cowger T, Hubbard RB, Zhang W, Stickney J, Shen B, Xie J. Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging. Adv Mater. 2014; 26(39):6761-6. Zhen Z, Tang W, Chuang YJ, Todd T, Zhang W, Lin X, Niu G, Liu G, Wang L, Pan Z, Chen X, Xie J. Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles. ACS Nano, 2014, 8(6):6004-6013. Zhen Z, Tang W, Todd T, Xie J. Ferritins as Nanoplatforms for Imaging and Drug Delivery. Expert Opinion on Drug Delivery, 2014, 29:1-10. Chuang YJ, Zhen Z, Zhang F, Mishra J, Tang W, Chen H, Liu F, Huang X, Todd T, Wang L, Chen X, Xie J and Pan Z. Photostimulable near-infrared persistent luminescent nanoprobes for ultrasensitive and longitudinal deep-tissue bio-imaging. Theranostics, 2014, 4(11):1112-22. Wang L, Tang W, Zhen Z, Chen H, Xie J, Zhao Q. Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T2 suppression. Magn Reson Imaging,2014, 32(6):671-8. Zhen, Z.; Tang, W.; Guo, C.; Chen, H.; Lin, X.; Liu, G.; Fei, B.; Chen, X.; Xu, B.; Xie, J. Ferritin Nanocages to Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer. ACS Nano 2013, 7(6):4830-7. Zhen, Z.; Tang, W.; Chen, H.; Lin, X.; Todd, T.; Wang, G.; Cowger, T.; Chen, X.; Xie, J. RGD-Modified Apoferritin Nanoparticles for Efficient Drug Delivery to Tumors. ACS Nano 2013, 7(8):6988-96. Todd TJ, Zhen Z, Xie J. Ferritin nanocages: great potential as clinically translatable drug delivery vehicles? Nanomedicine (Lond). 2013, 8(10):1555-7. Tang W, Zhen Z, Yang C, Wang L, Cowger T, Chen H, Todd T, Hekmatyar K, Zhao Z, Hou Y, and Xie J. Fe5C2 Nanoparticles with High MRI Contrast Enhancement for Tumor Imaging. Small, 2013, 26(22):1245-1249. Todd T, Zhen Z, Tang W, Chen H, Chuang Y-J, Deaton K, Pan Z, and Xie J. Iron Oxide Nanoparticle Encapsulated Diatoms for Magnetic Delivery of Small Molecules to Tumors. Nanoscale. 2013, 6(4):2073-2076. Chen, H.; Zhen, Z.; Tang, W.; Todd, T.; Chuang, Y. - J.; Wang, L.; Pan, Z.; Xie, J. Label-Free Luminescent Mesoporous Silica Nanoparticles for Imaging and Drug Delivery. Theranostics. 2013, 3(9):650-657. Chen H, Zhen Z, Todd T, Chu P, Xie J. Nanoparticles for Improving Cancer Diagnosis. Materials Science and Engineering: R: Reports. 2013, 74(3), 35-69. Cowger, T.; Xie, J. Polyaspartic Acid Coated Iron Oxide Nanoprobes for PET/MRI Imaging. Methods Mol. Biol. 2013, 1025, 225-35.