Merging of Chemistry and Biology

Our work encompasses the following areas: the development of methods for the detection of and protection against chemical/biological warfare agents, the preparation of combinatorial chemical libraries, the design/synthesis and evaluation of catalytic antibodies and enzyme inhibitors, solid-phase organic synthesis, antibody/peptide phage display libraries, the application of immunopharmacotherapy in the treatment of drug addiction and cancer, methods of prevention and treatment of obesity, diagnostic and therapeutic strategies towards neglected tropical diseases, and investigation and development of molecules that block quorum sensing in bacteria.

Gooyit, M., Tricoche, N., Javor, S., Lustigman, S., Janda, K.D., "Exploiting the polypharmacology of ?-carbolines to disrupt O. volvulus molting" ACS Med. Chem. Lett., XX, xxx (2015)

Lockner, J.W., Eubanks, L.M., Choi, J.L., Lively, J.M., Schlosburg, J.E., Collins, K.C., Globisch, D., Rosenfeld-Gunn, R.J., Wilson, I.A., Janda, K.D., "Flagellin as carrier and adjuvant in cocaine vaccine development" Mol. Pharmaceutics, 12, 653 (2015)

Lockner J.W., Lively, J.M., Collins, K.C., Vendruscolo, J.C.M., Azar, M.R., Janda, K.D., "A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity" J. Med. Chem., 58, 1005 (2015)

Xue, S., Javor, S., Hixon, M.S., Janda, K.D., "Probing BoNT/A protease exosites: Implications for inhibitor design and light chain longevity" Biochemistry, 53, 6820 (2014)

Hart, J.R., Garner, A.L., Yu, J., Ito, Y., Sun, M., Ueno, L., Rhee, J.-K., Baksh, M., Stefan, E., Hartl, M., Bister, K., Vogt, P.K., Janda, K.D., "Inhibitor of MYC identified in a Krohnke pyridine library" PNAS, 111(34), 12556 (2014)

Raffeiner, P., Rock, R., Schraff, A., Hartl, M., Hart, J.R., Janda, K.D., Vogt, P.K., Stefan, E., Bister, K., "In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential" Oncotarget, 5(19), 8869 (2014)

Ebanks, L.M., Ellis, B.A., Cai, X., Schlosburg, J.E., Janda, K.D., "A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies" Bioorg. Med. Chem. Lett., 24, 4664 (2014)

Harris, T.L., Lowery, C.A., Hixon, M.S., Janda, K.D., "A Platform stratifying a sequestering agent and a pharacological antagonist as a means to negate Botulinum neurotoxicity" ACS Chem. Neurosci., 5, 632 (2014)

Jacob, N.T., Lockner, J.W., Kravchenko, V.V., Janda, K.D., "Pharmacophore reassignment for induction of immunosurveillance cytokine TRAIL" Angew. Chem. Int. Ed., 53, 6628 (2014)

Hicks, M.J., Kaminsky, S.M., De, B.P., Rosenberg, J.B., Evans, S.M., Foltin, R.W., Andrenyak, D.M., Moody, D.E., Koob, G.F., Janda, K.D., Ricart Arbona, R.J., Lepherd, M.L., Crystal, R.G., "Fate of systematically administered cocaine in nonhuman primates treated with the dAd5GNE anti-cocaine vaccine" Hum. Gene Ther. Clin. Dev., 25(1), 40 (2014)

Collins, K.C., Schlosburg, J.E., Lockner, J.W., Bremer, P.T., Ellis, B.A., Janda, K.D., "Liquid tucaresol as an adjuvant for methamphetamine vaccine development" Chem. Commun., 50, 4079 (2014)

Collins, K.C., Janda, K.D., "Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse" Bioconjugate Chem., 25, 593 (2014)

Bremer, P.T., Hixon, M.S., Janda, K.D., "Benzoquinones as inhibitors of botulinum neurotoxin serotype A" Bioorg. Med. Chem., 22, 3971 (2014)

Gooyit, M., Tricoche, N., Lustigman, S., Janda, K.D., "Dual protonophore - chitinase inhibitors dramatically affect O. volvulvus molting" J. Med. Chem., 57, 5792 (2014)

Bremer P.T., Schlosburg, J.E., Lively, J.M., Janda, K.D., "Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy" Mol. Pharmaceutics, 11, 1075 (2014)

Seki, H., Pellett, S., Silhar, P., Stowe, G.N., Blanco, B., Lardy, M.A., Johnson, E.A., Janda, K.D., "Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain" Bioorg. Med. Chem., 22, 1208 (2014)

Silhar, P., Eubanks, L.M., Seki, H., Pellett, S., Javor, S., Tepp, W.H., Johnson, E.A., Janda, K.D., "Targeting Botulinum A cellular toxicity: A prodrug approach" Bioorg. Med. Chem., 56, 7870 (2013)

Lowery, C.A., Adler, M., Borrell, A., Janda, K.D., "Scorpion toxins for the reversal of BoNT-induced paralysis" Bioorg. Med. Chem. Lett., 23, 6743 (2013)

Cai, X., Whitfield, T.,Moreno, A.Y., Grant, Y., Hixon, M.S., Koob, G.F., Janda, K.D., "Probing the effects of hapten stability on cocaine vaccine immunogenicity" Mol. Pharm. , 10, 4176 (2013)

Garner, A.L., Fullagar, J.L., Day, J.A., Cohen, S.M., Janda, K.D., "Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors" J. Am. Chem. Soc., 135, 10014 (2013)