Dr. Yang is a professor in the Department of Biomedical Engineering and Lloyd & Dorothy Foehr Huck Chair in Regenerative Engineering at Pennsylvania State University (PSU). Dr. Yang’s research contributes to the innovation of citrate-based biomaterials and their applications in tissue engineering, drug delivery, biosensing, and bioimaging. Dr. Yang is also serving as a Co-Editor-in-Chief for "Bioactive Materials" (2021 IF 16.874), an Associate Editor for an AAAS journal, "Science Advances" (2021 IF 14.957), an Associate Editor for "Frontiers in Bioengineering and Biotechnology, Biomaterials section" (2021 IF 6.064), and an Editorial Board Member for ACS Biomaterials Science and Engineering, and Applied Materials Today. Selected Honors and Awards 2023 CAB Distinguished Leadership and Service Award 2022 Full Member, Sigma Xi, the Scientific Research Honor Society 2021 Fellow, American Association for the Advancement of Science (AAAS) 2020 Fellow, Biomedical Engineering Society (BMES) 2019 Lloyd & Dorothy Foehr Huck Chair in Regenerative Engineering 2018 Fellow, National Academy of Inventors (NAI) 2018 PSEAS Outstanding Research Award, Penn State University 2016 Fellow, American Institute of Medical and Biological Engineering (AIMBE) 2011 Outstanding Young Engineering Faculty Award, University of Texas, Arlington 2010 National Science Foundation (NSF) CAREER award

1) Methodology for new biomaterial development; 2) soft and hard tissue engineering; 3) cancer drug delivery and imaging; 4) stem cell/biomaterial interactions; 5) micro-/nano-medical device fabrication; 6) biosensing.

Dingbowen Wang, Yizhu Chen, Tunan Xia, Mariana Claudino, Allison Melendez, Xingjie Ni, Cheng Dong, Zhiwen Liu, Jian Yang. Citric Acid-Based Intrinsic Band-Shifting Photoluminescent Materials. Research, 2023, 6: article 0152. Yuki G. Yoshida, Su Yan, Hui Xu, Jian Yang. Novel metal nanomaterials to promote angiogenesis in tissue regeneration. Engineered Regeneration 2023, 4:265-276. https://doi.org/10.1016/j.engreg.2023.03.008 Keke Wu, Meimei Fu, Yitao Zhao, Ethan Gerhard, Yueli, Jian Yang, Jinshan Guo. Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives faciliate scarless wound healing. Bioactive Materials 2023, 20: 93-110. Tahir Haideri, Alessandro Howells, Yuqian Jiang, Jian Yang, Xiaoping Bao, Xiaojun Lance Lian. Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells. Cell Reports Methods 2022, https://doi.org/10.1016/j.crmeth.2022.100290. Kalindu Perera, Dat X. Nguyen, Dingbowen Wang, Aneetta E. Kuriakose, Jian Yang, Kytai T. Nguyen, Jyothi U. Menon. Biodegradable and Inherently Fluorescent pH-Responsive Nanoparticles for Cancer Drug Delivery. Pharmaceutical Research 2022, https://doi.org/10.1007/s11095-022-03317-8. Xinyu Tan, Ethan Gerhard, Yuqi Wang, Richard T. Tran, Hui Xu, Su Yan, Elias B.Rizk, April D. Armstrong, Yuxiao Zhou, Jing Du, Xiaochun Bai, Jian Yang. Development of Biodegradable Osteopromotive Citrate-based Bone Putty. Small 2022, https://doi.org/10.1002/smll.202203003. Jia Zhu, Honglei Zhou, Ethan Gerhard, Senhao Zhang, Flor Itzel Parra Rodriguez, Taisong Pan, Hongbo Yang, Yuan Lin, Jian Yang, Huanyu Cheng. Smart Bioadhesives for Wound Healing and Closure. Bioactive Materials 2023, 19: 360-375 Dingbowen Wang, Tunan Xia, Yuqi Wang, Yizhu Chen, Chenji Zhang, William T. Murray, Adam Thomas Schultz, Zhiwen Liu, Jian Yang. Citrate-based Fluorometric Sensor for Multi-halide Sensing. Smart Materials in Medicine 2022, 3: 374-381. Nil Kanatha Pande , Wei Xion , Lingyun Wan , Wei Chen , Brian Bui , Jian Yang , Eric Amador , Mingli Chen , Christina Xing , Aseem Atul Athavale , Yaowu Hao , Wirya Feizi , Lloyd Lumata. Aggregation-induced emission luminogens for highly effective microwave dynamic therapy. Bioactive Materials 2022, 7: 112-125 Andrea Gonsalves, Pranjali Tambe, Duong Le, Dheeraj Thakore, Aniket S. Wadajkar, Jian Yang, Kytai T. Nguyen, Jyothi U. Menon. Synthesis and Characterization of a Novel pH-Responsive Drug-Releasing Nanocomposite Hydrogel for Skin Cancer Therapy and Wound Healing. Journal of Materials Chemistry B 2021, DOI: 10.1039/d1tb01934a Dingbowen Wang, Michelle Laurel Kuzma, Xinyu Tan, Tong-Chuan He, Cheng Dong, Zhiwen Liu, Jian Yang. Phototherapy and Optical Waveguides for the Treatment of Infection. Advanced Drug Delivery Reviews 2021, 179: 114036. Jia Zhu, Shangbin Liu, Zhihui Hu, Xianzhe Zhang, Ning Yi, Kairui Tang, Michael Gregory Dexheimer, Xiaojun Lian, Qing Wang, Jian Yang, Jennifer Gray, Huanyu Cheng. Laser-induced graphene non-enzymatic glucose sensors for on-body measurements. Biosensors and Bioelectronics 2021, 193: 113606. Yukun Mao, Na Ni, Linjuan Huang, Jiaming Fan, Hao Wang, Fang He, Qing Liu, Deyao Shi, Kai Fu, Mikhail Pakvasa, William Wagstaff, Andrew Blake Tucker, Connie Chen, Russell R Reid, Rex C Haydon, Sherwin H Ho, Michael J Lee, Tong-Chuan He, Jian Yang, Le Shen, Lin Cai, Hue H Luu. Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs). Genes & Diseases 2021, 8: 918-930. Zain Siddiqui , Biplab Sarkar , Ka Kyung Kim , Arjun Kumar , Reshma Paul , Aryan Mahajan, Jonathan M. Grasman , Jian Yang , Vivek A. Kumar. Self-assembling peptide hydrogels facilitate vascularization in two-component scaffolds. Chemical Engineering Journal 2021, 422: 130145. Xia Zhao, Bo Huang, Hao Wang, Na Ni, Fang He, Qing Liu, Deyao Shi, Connie Chen, Piao Zhao, Xi Wang, William Wagstaff, Mikhail Pakvasa, Andrew B. Tucker, Michael J. Lee, Jennifer Moriatis Wolf, Russell R. Reid, Kelly Hynes, Jason Strelzow, Sherwin H. Ho, Tengbo Yu, Jian Yang, Le Shen, Tong-Chuan He, and Yongtao Zhang. A functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs). American Journal of Translational Research 2021, 13(5):4233-4250. Zain Siddiqui, Biplab Sarkar, K- Kyung Kim, Nurten Kadincesme, Reshma Paul, Arjun Kumar, Yoshifumi Kobayashi, Abhishek Roy, Marwa Choudhury, Jian Yang, Emi Shimizu, Vivek Kumar. Angiogei Hydrogels for dental pulp revascularization. Acta Biomaterialia 2021, 126:109-118 Jia Zhu, Zhihui Hu, Chaoyun Song, Ning Yi, Zhaozheng Yu, Zhendong Liu, Shangbin Liu, Mengjun Wang, Michael Gregory Dexheimer, Jian Yang, Huanyu Cheng. Stretchable wideband dipole antennas and rectennas for RF energy harvesting. Materials Today Physics 2021, 18:100377. https://doi.org/10.1016/j.mtphys.2021.100377 Qiong Wei, Xuechen Shi, Tiankai Zhao, Pingqiang Cai, Tianwu Chen, Yao Zhang, Changjin Huang, Jian Yang, Xiaodong Chen, and Sulin Zhang. Actin-ring segment switching drives nonadhesive gap closure. PNAS 2021, 117 (52) 33263-33271. DOI: 10.1073/pnas.2010960117. Shuo Tang, Kai Chi, Hui Xu, Qiang Yong, Jian Yang, Jeffrey M. Catchmark. A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications. Carbohydrate Polymers 2021, 252: 117123. https://doi.org/10.1016/j.carbpol.2020.117123. Meng Zheng, Jiazhi Guo, Qing Li, Jian Yang, Yi Han, Hongcai Yang, Mali Yu, Lianmei Zhong, Di Lu, Limei Li, Lin Sun. Syntheses and characterization of anti-thrombotic and anti-oxidativeGastrodin-modified polyurethane for vascular tissue engineering. Bioactive Materials 2021, 6:404-419. Gloria B. Kim, Virginia Aragon-Sanabria, Lauren Randolph, Hali Jiang, Joshua A. Reynolds, Becky S. Webb, Achuthamangalam Madhankumar, Xiaojun Lian, James R. Connor, Jian Yang, Cheng Dong. High-Affinity Mutant Interleukin-13 Targeted CAR T Cells Enhance Delivery of Clickable Biodegradable Fluorescent Nanoparticles to Glioblastoma. Bioactive Materials 2020, 5:624-635 Qing Li, Limei Li, Mali Yu, Meng Zheng, Yao Li, Jian Yang, Min Dai, Lianmei Zhong, Lin Sun, Di Lu. Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration. Journal of Biomedical Research Part A 2020, 108:1713-1725. Jinshan Guo, Xinggui Tian, Denghui Xie, Kevin Rahn, Ethan Gerhard, Michelle Laurel Kuzma, Dongfang Zhou, Cheng Dong, Xiaochun Bai, Zhihui Lu, and Jian Yang. Citrate-based tannin-bridged bone composites for lumbar fusion. Advanced Functional Materials 2020, DOI: 10.1002/adfm.202002438 . Michelle Kuzma, Ethan Gerhard, Dingying Shan, Jian Yang. Advances in Bioresorbable Electronics and Uses in Biomedical Sensing. In "Interfacing Bioelectronics and Biomedical Sensing". Eds: Hung Cao, Todd Coleman, Tzung K. Hsiai, Ali Khademhosseini. Springer, Cham. 2020, pp29-92. [link] Xili Lu, Sanjun Shi, Hanmei Li, Ethan Gerhard, Zhihui Lu, Xinyu Tan, Wenliang Li, Kevin M, Rahn, Denghui Xie, Guodong Xu, Fang Zou, Xiaochun Bai, Jinshan Guo, Jian Yang. Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives. Biomaterials 2020, 232, 119719. https://doi.org/10.1016/j.biomaterials.2019.119719. Nikhil Pandey, Jyothi U. Menon, Masaya Takahashi, Jer-Tsong Hsieh, Jian Yang, Kytai T. Nguyen, Aniket S. Wadajkar. Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers. Nanotheranostics 2020; 4(1): 1-13. doi: 10.7150/ntno.39810 Aneetta Elizabeth Kuriakose, Nikhil Pandey, Dingying Shan, Subhash Banerjee, Jian Yang, Kytai Truong Nguyen. Photoluminescent polylactone-based theranostic nanoparticles for cardiovascular applications. Front. Bioeng. Biotechnol., 2019 | https://doi.org/10.3389/fbioe.2019.00353 Chuying Ma, Michelle L. Kuzma, Xiaochun Bai, Jian Yang. Biomaterials-Based Metabolic Regulation in Regenerative Engineering. Advanced Science 2019, 1900819. https://doi.org/10.1002/advs.201900819. Dingying Shan, Chuying Ma, Jian Yang. Enabling Biodegradable Functional Biomaterials for the Management of Neurological Disorders. Advanced Drug Delivery Reviews 2019, https://doi.org/10.1016/j.addr.2019.06.004. Yun He, Qiyao Li, Chuying Ma, Denghui Xie, Limei Li, Yitao Zhao, Dingying Shan, Sarah K. Chomos, Cheng Dong, John W. Tierney, Lin Sun, Di Lu, Li Gui, Jian Yang. Development of Osteopromotive Poly (octamethylene citrate glycerophosphate) (POC-GP) for Enhanced Bone Regeneration. Acta Biomaterialia 2019, 93:180-191.. Solaiman Tarafder, Joseph Gulko, Daniel Kim, Kun Hee sim, Shawn Gutman, Jian Yang, James L. Cook, Chang H. Lee. Effect of dose and release rate of CTGF and TGFß3 on avascular meniscus healing. Journal of Orthopaedic Research 2019, 37(7):1555-1562. Roshni Iyer, Aneetta E. Kuriakose, Serkan Yaman, Lee-Chun Su, Dingying Shan, Jian Yang, Jun Liao, Liping Tang, Subhash Banerjee, Hao Xua, Kytai T. Nguyen. Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases. International Journal of Pharmaceutics 2019, 554:212-223. Wenchong Zou, Mingqiang Lai, Yue Zhang, Lei Zheng, Zhe Xing, Ting Li, Zhipeng Zou, Qiancheng Song, Xiaoyang Zhao, Laixin Xia, Jian Yang, Anling Liu, Han Zhang, Zhong-Kai Cui, Yu Jiang, and Xiaochun Bai. Exosome Release Is Regulated by mTORC1. Advanced Scinece 2018. DOI: 10.1002/advs.201801313 Chuying Ma, Xinggui Tian, Jimin Peter Kim, Denghui Xie, Xiang Ao, Dingying Shan, Qiaoling Lin, Maria Hudock, Xiaochun Bai, Jian Yang. Citrate-based materials fuel human stem cells by metabonegenic regulation. PNAS 2018, 115 (50): E11741-E11750 Hua Wang, Haiyan Zhang, Qiuyi Sun, Jian Yang, Chun Zeng, Changhai Ding, Daozhang Cai, Anling Liu, Xiaochun Bai. Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression. Journal of Cellular Physiology 2018, 1–11. https://doi.org/10.1002/jcp.27088. Dingying Shan, Ethan Gerhard, Chenji Zhang, John William Tierney, Daniel Xie, Zhiwen Liu, Jian Yang. Polymeric biomaterials for biophotonic applications. Bioactive Materials 2018, 3:434-445. Dingying Shan, Jer-Tsong Hsieh, Xiaochun Bai, Jian Yang. Citrate-based fluorescent biomaterials. Advanced Healthcare Materials 2018, e1800532. DOI: 10.1002/adhm.201800532. Hongdong Chen, Yeyang Wang, Huaiqian Dai, Xinggui Tian, Zhong-Kai Cui, Zhenguo Chen, Le Hu, Qiancheng Song, Anling Liu, Zhiyong Zhang, Guozhi Xiao, Jian Yang, Yu Jiang, Xiaochun Bai. Bone and plasma citrate is reduced in osteoporosis. Bone 2018,114:189-197. Dingying Shan, Sri-Rajasekhar Kothapalli, Dino J. Ravnic, Ethan Gerhard, Jimin P. Kim, Jinshan Guo, Chuying Ma, Jiazhi Guo, Li Gui, Lin Sun, Di Lu, Jian Yang. Development of Citrate-based Dual-Imaging Enabled Biodegradable Electroactive Polymers. Advanced Functional Materials 2018, DOI:10.1002/adfm.201801787.. Solaiman Tarafder, Joseph Gulko, Kun Sim, Jian Yang, James Cook, Chang Lee. Engineered healing of avascular meniscus tears by stem cell recruitmen. Scientific Reports 2018, 8:8150. DOI:1038/s51598-018-26545-8. Chuying Ma, Ethan Gerhard, Di Lu, Jian Yang. Citrate chemistry and biology for biomaterials design. Biomaterials 2018, 178:383-400. Kazim Moncal; Dong Heo, Kevin Godzik, Donna Sosnoski, Oliver Mrowczynski, Elias Rizk, Veli Ozbolat, Scott Tucker, Ethan Gerhard, Madhuri Dey, Greg Lewis, Jian Yang, Ibrahim Ozbolat. 3D Printing of Poly (e-caprolactone)/ Poly (D, L-lactide-co-glycolide)/ Hydroxyapatite Composite Constructs for Bone Tissue Engineering. Journal of Materials Research 2018, 33(5): 909-920. Zhenqi Jiang, Yuchen Tian, Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Juan Li, Jian Yang, and Aiguo Wu. pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time. Biomaterials 2018, 170:70-81. Gloria B. Kim, Yongjie Chen, Weibo Kang, Jinshan Guo, Russell Payne, Hui Li, Qiong Wei, Julianne Baker, Cheng Dong, Sulin Zhang, Pak Kin Wong, Elias B. Rizk, Jiazhi Yan, Jian Yang. The Critical Chemical and Mechanical Regulation of Folic Acid on Neural Engineering. Biomaterials 2018,178:504-516. Jinshan Guo, Wei Sun, Jimin Peter Kim, Xili Lu, Qiyao Li, Min Lin, Oliver Mrowczynski, Elias Rizk, Juange Cheng, Guoying Qian, Jian Yang. Development of tannin-inspired antimicrobial bioadhesives. Acta Biomaterialia 2018, 72:35-44. Li Zeng, Xinwei Deng, Jian Yang. Constrained gaussian process with application in tissue-engineering scaffold biodegradation. IISE Transactions, 2018, 50(5):431-447 . Jiansen Lu, Haiyan Zhang, Daozhang Cai, Chun Zeng, Pinglin Lai, Yan Shao, Hang fang, Delong Li, Jiayao Ouyang, Chang Zhao, Denghui Xie, Bin Huang, Jian Yang, Yu Jiang, Xiaochun Bai. Positive-feedback regulation of subchondral H-type vessel formation by chondrocyte promotes osteoarthritis development in mice. Journal of Bone and Mineral Research 2018, 33:909-920. Chuying Ma, Ethan Gerhard, Qiaoling Lin, Silun Xia, April Dawn Armstrong, Jian Yang. In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering. Bioactive Materials 2018, 3:19-27.