National Science Foundation CAREER Award, 2011 NSERC of Canada Predoctoral Fellowship, 1998-2003

Analytical/Biological/Physical

Analytical

Protein Dynamics by High Field NMR Biological

Protein Dynamics in Enzyme Function and Regulation Physical

Protein Dynamics by High Field NMR

Yang, X., E.D. Smidansky, K.R. Maksimchuk, D. Lum, J.L. Welch, J.J. Arnold, C.E. Cameron and D.D. Boehr, Motif D or viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition. Structure, 2012, 20, 1519-1527. Weikl, T.R. and D.D. Boehr, Conformational selection and induced changes along the catalytic cycle of Escherichia.coli dihydrofolate reductase. Proteins, 2012, 80, 2369-2383. Zaccardi, M.J., O. Mannweiler and D.D. Boehr, Differences in the catalytic mechanisms of mesophilic and thermophilic indole-3-clycerol phosphate synthase enzymes at their adaptive temperatures. Biochem. Biophys. Res. Commun., 2012, 418, 324-329. Boehr, D.D. Promiscuity in protein-RNA interactions: Conformational ensembles facilitate molecular recognition in the spliceosome: Conformation diversity in U2AF(65) facilitates binding to diverse RNA sequences. Biosessays, 2012, 34, 174-180. Yang, X., J.L. Welch, J.J. Arnold and D.D. Boehr, Long-range interaction networks in the function and fidelity of poliovirus RNA-dependent RNA polymerase studied by nuclear magnetic resonance. Biochemistry, 2010, 49, 9361-9371. Boehr, D.D., McElheny, D., Dyson, H.J. and Wright, P.E. Millisecond fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands. Proc. Natl. Acad. Sci. USA. 2010, 107, 1373-1378. Boehr, D.D., Nussinov, R. and Wright, P.E. The role of dynamic conformational ensembles in molecular recognition. Nat. Chem. Biol. 2009, 5, 789-796. Boehr, D.D., McElheny, D., Dyson, H.J. and Wright, P.E. The dynamic energy landscape of dihyrofolate reductase catalysis. Science, 2006, 313, 1638-1642.

Boehr, D.D., Dyson, H.J and Wright, P.E. An NMR perspective on enzyme dynamics. Chem. Rev., 2006, 3055-3079.