Davidson Professor of Science and Professor of Chemistry. B. S., 1980, Case Western Reserve University. Ph.D., 1986, University of Minnesota. NIH Postdoctoral Fellow, 1986-87, University of Wisconsin at Madison. Organic, organometallic, and bioorganic reaction mechanisms. Exploration for new kinds of mechanisms and mechanistic effects in reactions, including especially dynamic effects and tunneling in reaction mechanisms; isotope effects and their use in detailing transition state geometries.

Bioorganic Chemistry/Molecular Structure/Spectroscopy and Dynamics/Synthesis/Theoretical Chemistry

Absolute Asymmetric Synthesis Asymmetric Amplification Dynamic Effects Isotope Effects Organic Chemistry Reaction Mechanisms

"Newtonian Kinetic Isotope Effects. Observation, Prediction, and Origin of Heavy-Atom Dynamic Isotope Effects" K. K. Kelly, J. S. Hirschi, and D. A. Singleton, J. Am. Chem. Soc. 2009, 131, 8382-8383. "Dynamics and the Failure of Transition State Theory in Alkene Hydroboration" Y. Oyola and D. A. Singleton, J. Am. Chem. Soc. 2009, 131, 3130-3131. "Transition State Geometry Measurements from 13C Isotope Effects. The Experimental Transition State for the Epoxidation of Alkenes with Oxaziridines" J. S. Hirschi, T. Takeya, C. Hang, and D. A. Singleton, J. Am. Chem. Soc. 2009, 131, 2397-2403. "Control Elements in Dynamically-Determined Selectivity on a Bifurcating Surface," J. B. Thomas, J. R. Waas, M. Harmata, and D. A. Singleton, J. Am. Chem. Soc. 2008, 130, 14544-14555. "Phenomenon of Optical Self-Purification of Chiral Non-Racemic Compounds," V. A. Soloshonok, H. Ueki, M. Yasumoto, S. Mekala, J. S. Hirschi, and D. A. Singleton, J. Am. Chem. Soc. 2007, 129, 12112-12114. "Dynamic Effects on the Periselectivity, Rate, Isotope Effects, and Mechanism of Cycloadditions of Ketenes with Cyclopentadiene," B. R. Ussing, C. Hang, and D. A. Singleton, J. Am. Chem. Soc. 2006, 128, 7594-7607. "'Concerted' Transition State, Stepwise Mechanism. Dynamics Effects in C2-C6 Enyne Allene Cyclizations," T. Bekele, M. A. Lipton, D. A. Singleton and C. F. Christian, J. Am. Chem. Soc. 2005, 127, 9216-9223. "Mechanism and Origin of Enantioselectivity in the Rh2(OAc)(DPTI)3-Catalyzed Cyclopropenation of Alkynes," D. T. Nowlan III and D. A. Singleton, J. Am. Chem. Soc. 2005, 127, 6190-6191. "Isotope Effects and the Nature of Enantioselectivity in the Shi Epoxidation. The Importance of Asynchronicity," D. A. Singleton and Z. Wang, J. Am. Chem. Soc. 2005, 127, 6679-6685. "The Normal Range for Secondary Swain-Schaad Exponents Without Tunneling or Kinetic Complexity," J. Hirschi and D. A. Singleton, J. Am. Chem. Soc. 2005, 127, 3294-3295. "Isotope Effects, Dynamics, and the Mechanism of Solvolysis of Aryldiazonium Cations in Water," B. R. Ussing and D. A. Singleton, J. Am. Chem. Soc. 2005, 127, 2888-2899.