Professor of Chemistry. B. A., 1986, Texas A&M University. Ph. D., 1991, Colorado State University. American Cancer Society Postdoctoral Fellow, 1991-93, Harvard University. Organic Chemistry. Structure elucidation, total synthesis, and mode of actions studies of physiologically active natural products; synthetic methodology including asymmetric catalysis

Bioorganic Chemistry/Synthesis

Total Synthesis and Biomechanistic Studies of Marine Natural Products β-Lactones: Novel Synthetic Targets, Enzyme Inhibitors, and Vehicles for Synthesis New Methods for Simultaneous Arming and SAR Studies of Natural Products and Subsequent Cellular Receptor Isolation

"Facile Sythesis of the Trans-Fused Azabicyclo [3.3.0] Octane Core of Palau'amine and the Tricyclic Core of Axinellamine from a Common Intermediate" Zancanella, M. A.; Romo, D. Org. Lett. 2008, ASAP. "Concise Synthesis of Spirocyclic, Bridged γ-Butrolactones via Stereospecific, Dyotropic Rearrangements of β-Lactones Involving 1,2-Acyl and δ-Lactone Migrations" Purohit, V. C.; Matla, A. S.; Romo, D. J. Am. Chem. Soc. 2008,130, 10478-10479. "Highly Diastereoselective, Tandem, Three-Component Synthesis of Tetrahydrofurans from Ketoaldehydes via Silylated β-Lactone Intermediates: Application to a Colpsinol B Fragment" Mitchell, T. A.; Zhao, C.; Romo, D. Angew. Chem. Int. Ed. 2008, 47, 5026-5029. "β-Lactam Congeners of Orlistat as Inhibitors of Fatty Acid Synthase" Zhang, W.; Richardson, R. D.; Chamni, S.: Smith, J. W.; Romo, D. Bioorg. Med. Chem. Lett. 2008, 28, 2491-2494. (Featured in Chemical & Engineering News, "Fat Chance to Cure Cancer", June 23, 2008) "Enantioselective Synthesis of (+) Monobromophakellin and (+)-Phakellin: A Concise Phakellin Annulation Strategy Applicable to Palau'amine" Wang, S.; Romo, D. Angew. Chem. Int. Ed. 2008, 47, 1284-1286. (Highlighted in Synfacts 2008, 7, 678) "Simultaneous Arming and Structure/Activity Studies of Natural Products Employing O-H Insertions: An Expedient and Versatile Strategy for Natural Products-Based Chemical Genetics" Peddibhotla, S.; Dang, Y.; Liu, J. O.; Romo, D. J. Am. Chem. Soc., 2007, 129, 12222-12231. (Featured in Chemical & Engineering News, "Tagging Natural Products", October 1, 2007) "Substrate-Dependent Targeting of Eukaryotic Translation Initiation Factor 4A by Pateamine A: Negation of Domain-Linker Regulation of Activity" Low, W.-K.; Dang, Y.; Bhat, S.; Romo, D.; Liu, J. O. Chem. & Biol. 2007, 14, 1-13. "Concise Total Synthesis of (+/-)- Salinosporamide A, (+/-)-Cinnabaramide A, and Derivatives via a Bis-Cyclization Process: Implications for a Biosynthetic Pathway?" Ma, G.; Nguyen, H.; Romo, D. Org. Lett. 2007, 9, 2143-2146. (Highlighted in Synfacts 2007, 10, 1014) "Total Synthesis of Belactosin C and Congeners via the Tandem Mukaiyama Aldol-Lactonization Process" Cho, S. W.; Romo, D. Org. Lett. 2007, 9, 1537-1540. (Highlighted in Synfacts 2007, 8, 789) "Isolation and Identification of Eukaryotic Initiation Factor 4A as a Molecular Target for the Marine Natural Product Pateamine A" Low, W.-K.; Dang, Y.; Schneider-Poetsch, T.; Shi, Z.; Choi, N. S.; Rzasa, R. M.; Shea, H. A.; Li, S.; Park, K.; Ma, G.; Romo, D.; Liu, J. O. Methods in Enzymology 2007, 431, 303-0324. "Eukaryotic Initiation Factor 2α-independent Pathway of Stress Granule Induction by the Natural Product Pateamine A" Dang Y.; Kedersha, N.; Low, W.-K.; Romo, D.; Gorospe, M.; Kaufman, R.; Anderson, P.; Liu, J. O. J. Biol. Chem. 2006, 281, 32870-32878. "Synthesis, Characterization, and Utility of Thermoresponsive Natural/Unnatural Product Macroligands for Affinity Chromatography" Zhou, M.; Sivaramakrishnan, A.; Ponnamperuma, K.; Low, W.-K.; Li, C.; Zhang, Y.; Liu, J. O.; Bergbreiter, D.; Romo, D. Org. Lett. 2006, 8, 5247-5250. "Bicyclic and Tricyclic-β-Lactones via an Organonucleophile Bis-cyclization of Keto-Acids: Enantioselective Synthesis of (+)-Dihydroplakevulin" Henry-Riyad, H.; Lee, C. S.; Purohit, V.; Romo, D. Org. Lett. 2006, 8, 4363-4366. "Practical, Catalytic, Asymmetric Synthesis of β-Lactones via a Sequential Ketene Dimerization/Hydrogenation Process: Inhibitors of the Thioesterase Domain of Fatty Acid Synthase" Purohit, V. C.; Richardson, R. D., Smith, J. W.; Romo, D. J. Org. Chem. 2006, 71, 4549-4558.