Educational Background M. S., 1999, Ecole Supérieure de Chimie Physique Electronique de Lyon Ph.D., 2002, University of Houston Graduate Education M.Sc. Ecole Supérieure de Chimie Physique Electronique de Lyon (1999) Ph.D. University of Houston (2002) Postdoc. The Rockefeller University (2002-2006) Joined Texas A&M in 2006

Current Activities Our goal is to determine how proteins function in space and time in the context of complex cellular networks. We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics. In particular, we use semi-synthetic light-activatable proteins as biophysical probes to investigate protein mechanisms inside living cells. Areas of interest include the important but poorly understood process of protein S-acylation, signal transduction, and protein trafficking.

Brock, DJ, Kondow-McConaghy, HM, Hager, EC, Pellois, JP. Endosomal escape and cytosolic penetration of macromolecules mediated by synthetic delivery agents. Bioconjug. Chem. 2018; :. doi: 10.1021/acs.bioconjchem.8b00799. PubMed PMID:30462487. . Fang, Y, Lian, X, Huang, Y, Fu, G, Xiao, Z, Wang, Q et al.. Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy. Small. 2018; :e1802709. doi: 10.1002/smll.201802709. PubMed PMID:30222252. . Allen, JK, Brock, DJ, Kondow-McConaghy, HM, Pellois, JP. Efficient Delivery of Macromolecules into Human Cells by Improving the Endosomal Escape Activity of Cell-Penetrating Peptides: Lessons Learned from dfTAT and its Analogs. Biomolecules. 2018;8 (3):. doi: 10.3390/biom8030050. PubMed PMID:29997347. PubMed Central PMC6165022. Brock, DJ, Kustigian, L, Jiang, M, Graham, K, Wang, TY, Erazo-Oliveras, A et al.. Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides. Traffic. 2018;19 (6):421-435. doi: 10.1111/tra.12566. PubMed PMID:29582528. PubMed Central PMC5948172. Lian, X, Huang, Y, Zhu, Y, Fang, Y, Zhao, R, Joseph, E et al.. Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy. Angew. Chem. Int. Ed. Engl. 2018;57 (20):5725-5730. doi: 10.1002/anie.201801378. PubMed PMID:29536600. . Stubbendieck, RM, Brock, DJ, Pellois, JP, Gill, JJ, Straight, PD. Linearmycins are lytic membrane-targeting antibiotics. J. Antibiot. 2018;71 (3):372-381. doi: 10.1038/s41429-017-0005-z. PubMed PMID:29348524. . Lian, X, Erazo-Oliveras, A, Pellois, JP, Zhou, HC. High efficiency and long-term intracellular activity of an enzymatic nanofactory based on metal-organic frameworks. Nat Commun. 2017;8 (1):2075. doi: 10.1038/s41467-017-02103-0. PubMed PMID:29234027. PubMed Central PMC5727123. Najjar, K, Erazo-Oliveras, A, Mosior, JW, Whitlock, MJ, Rostane, I, Cinclair, JM et al.. Unlocking Endosomal Entrapment with Supercharged Arginine-Rich Peptides. Bioconjug. Chem. 2017;28 (12):2932-2941. doi: 10.1021/acs.bioconjchem.7b00560. PubMed PMID:29065262. PubMed Central PMC5905407. Libardo, MDJ, Wang, TY, Pellois, JP, Angeles-Boza, AM. How Does Membrane Oxidation Affect Cell Delivery and Cell Killing? Trends Biotechnol. 2017;35 (8):686-690. doi: 10.1016/j.tibtech.2017.03.015. PubMed PMID:28460718. PubMed Central PMC5522782. Wang, TY, Libardo, MDJ, Angeles-Boza, AM, Pellois, JP. Membrane Oxidation in Cell Delivery and Cell Killing Applications. ACS Chem. Biol. 2017;12 (5):1170-1182. doi: 10.1021/acschembio.7b00237. PubMed PMID:28355059. PubMed Central PMC5905413.