Associate Professor of Chemistry. Diploma, 1999, Swiss Federal Institute of Technology (ETH) Zurich. Ph.D., 2004, Swiss Federal Institute of Technology (ETH) Zurich. Postdoctoral Fellow 2004-2006, University of California, Berkeley and Lawrence Berkeley National Laboratory. Biophysical Chemistry. Protein structure and function, biological membranes, nuclear magnetic resonance (NMR), NMR methodology.

Bioorganic Chemistry/Bioanalytical Chemistry/Molecular Structure/Spectroscopy and Dynamics

Membrane Biochemistry and Biophysics Nuclear Magnetic Resonance (NMR) and Hyperpolarization Structure and Functional Mechanisms of Membrane Proteins

Hwang, S., Shao, Q., Williams, H., Hilty, C. and Gao, Y.-Q. Methanol Strengthens Hydrogen Bonds and Weakens Hydrophobic Interactions in Proteins - A Combined Molecular Dynamics and NMR study. Journal of Physical Chemistry B, 115 (20):6653-6660 (2011). Hwang, S. and Hilty, C. Folding determinants of disulfide bond forming protein B explored by solution NMR Spectroscopy. Proteins-Structure Function and Bioinformatics 79 (5):1365-1375 (2011). Chen, H.-Y., Lee, Y., Bowen, S. andHilty, C. Spontaneous emission of NMR signals in hyperpolarized proton spin systems. Journal of Magnetic Resonance 208 (2): 204-209 (2011). Zeng, H., Lee, Y. and Hilty, C. Quantitative rate determination by DNP enhanced NMR of a Diels-Alder reaction. Analytical Chemistry 82 (21): 8897-8902 (2010). Hilty, C. and Bowen, S. Applications of dynamic nuclear polarization to the study of reactions and reagents in organic and biomolecular chemistry. Organic and Biomolecular Chemistry 8 (15): 3361-3365 (2010). Bowen, S., Hilty, C. Rapid sample injection for hyperpolarized NMR spectroscopy Physical Chemistry Chemical Physics 12 (22): 5766-5770 (2010). Bowen, S., Hilty, C. Temporal chemical shift correlations in reactions studied by hyperpolarized NMR. Analytical Chemistry 81 (11): 4543-4547 (2009). Lee, D., Walter, K. F. A., Brückner, A.-K., Hilty, C., Becker, S., Griesinger, C. Bilayer in Small Bicelles Revealed by Lipid?Protein Interactions Using NMR Spectroscopy. Journal of the American Chemical Society 130 (42): 13822-13823 (2008). Bowen, S., Zeng, H., Hilty, C. Chemical Shift Correlations from Hyperpolarized NMR by Off-Resonance Decoupling. Analytical Chemistry 80 (15): 5794-5798 (2008). Bowen, S., Hilty, C. Time-resolved dynamic nuclear polarization enhanced NMR Spectroscopy. Angewandte Chemie International Edition 47 (28): 5235-5237 (2008).