Lee's research interests include metabolomics, lipidomics, chemometrics, sample profiling methods and pharmaceutical and clinical analysis.

His more recent work is concerned with pharmaceutical analysis and metabolomics. Metabolomics is the global study of all the small molecules (or metabolites) produced in the human body, looking for causes of disease. This provides possible sources of new drugs and new ways of diagnosing disease based upon a distinct change in the body. Global profiling of metabolites involves using a mixture of techniques for the analysis of all different types of molecules. This includes:

Ultra and high performance liquid chromatography (UHPLC and HPLC) Gas chromatography and mass spectrometry using single and triple quadrupoles and time-of-flight instruments

Abu Abed, Omar S., Elkordy, Amal, Chaw, Cheng Shu, Williams, Lee and Carlile, Mark (2016) Development and Characterisation of Polymeric Nanacapsules Containing Macromolecule. Molecular Therapy, 24 (Supp 1). S237-S238. ISSN 1525-0016 Childs, Stephen, Haroune, Nicolas, Williams, Lee and Gronow, M (2016) Determination of cellular glutathione: glutathione disulphide ratio in prostate cancer cells by high performance liquid chromatography with electrochemical detection. Journal of Chromatography A, 1437. pp. 67-73. ISSN S0021-9673 Williams, Lee, Haroune, Nicolas, Childs, Stephen and Gronow, Michael (2016) Determination of cellular glutathioneglutathione disulfide ratio. Journal of Chromatography A (1437). pp. 67-73. Rashid, M, Auger, V, Williams, Lee, Dou, Y, Pruneanu, S and Ali, Z (2007) Polymer based microchip for combined capillary electrophoresis and electrochemical detection. Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE. pp. 111-114. ISSN 1557-170X Whiteley, P, Waring, R, Williams, Lee, Klovrza, L, Nolan, F, Smith, S, Farrow, M, Dodou, Kalliopi, Lough, John and Shattock, Paul (2006) Spot urinary creatinine excretion in pervasive developmental disorders. Pediatrics International, 48 (3). 292-297.. ISSN 1442-200X