Paul's research interest is drug action, the mechanism of action of therapeutic and related compounds on mitochondrial function, and more specifically anti-depressant action and the mitochondrial effects of anti-depressants.

Markham, Anthony, Bains, R., Franklin, Paul and Spedding, M. (2014) Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF? British Journal of Pharmacology, 171 (8). pp. 2206-2229. ISSN 0007-1188 Markham, Anthony, Cameron, Ian, Bains, Rasneer, Franklin, Paul, Kiss, Janos P, Schwendimann, Leslie, Gressens, Pierre and Spedding, Michael (2012) Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways. European Journal of Neuroscience, 35 (3). pp. 366-374. ISSN 0953816X Markham, Anthony, Cameron, Ian and Franklin, Paul (2004) BDNF increases mitochondrial respiratory coupling, and glutamate metabolism, at complex I, but not complex II. European Journal Of Neuroscience, 20 (5). pp. 1189-1196. ISSN 1460-9568 Markham, Anthony, Cameron, Ian, Franklin, Paul and Spedding, Michael (2004) BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II. European Journal of Neuroscience, 20 (5). pp. 1189-1196. ISSN 0953816X Markham, Anthony, Cameron, Ian, Bains, Rasneer, Franklin, Paul, Kiss, JP, Schwendimann, L, Gressens, P and Spedding, M Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways. European Journal Neuroscience, 35 (3). pp. 366-374. ISSN 1460-9568