Anderson, Rosaleen
Professor
所属大学: Sunderland University
所属学院: Department of Pharmacy, Health and Well-being
个人简介
Roz Anderson is Professor of Pharmaceutical Chemistry in the School of Pharmacy. She graduated from the University of Newcastle upon Tyne with a BSc (Hons) in Chemistry and a PhD in Organic Chemistry, then joined the University of Sunderland in 1987, when it was Sunderland Polytechnic, as a post-doctoral fellow.
After securing a Lectureship in Pharmaceutical Chemistry in 1990, Roz was promoted to Senior Lecturer, then Principal Lecturer, and finally Professor in 2008. From 2003-2009, she was programme leader for the MPharm programme; since 2009, Roz has led the laboratory-based science research at the University and is joint lead for the Health Sciences and Well-being Research Beacon.
研究领域
Roz’s research interests are rooted in pharmaceutical chemistry, covering rational drug design, prodrugs, proteomics, and analytical science, with a focus on finding solutions to medicinal problems and the translation of results into clinical use.
Her current research interests include:
the design of novel prodrugs for the treatment of the rare disease cystinosis; investigation of the protein expression in cystinotic cells and the effects of the treatment cysteamine; the design, synthesis and evaluation of new agents for the detection and identification of bacteria in clinical, food and environmental samples; investigations into antibiotic resistant clinical bacteria and novel agents for their eradication; the design, synthesis and evaluation of novel agents for the treatment of skin diseases, such as psoriasis and eczema; the development of novel agents and diagnostic tests to support the use of personalised medicines.
近期论文
Bedernjak, Alexandre, Zaytsev, A.V., Babolat, M., Cellier, M., James, A.L., Orenga, S., Perry, J.D., Groundwater, Paul and Anderson, Rosaleen (2016) Synthesis and evaluation of novel 7- and 8-aminophenoxazinones for the detection of β-alanine aminopeptidase activity and the rapid identification of Pseudomonas aeruginosa in clinical samples. Journal of Medicinal Chemistry. ISSN 0022-2623 Frost, Lisa, Suryadevara, Pratap, Cannell, Stephanie, Groundwater, Paul, Hambleton, Paul and Anderson, Rosaleen (2016) Synthesis of diacylated γ-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine. European Journal of Medicinal Chemistry, 109. pp. 206-215. Suliman, A.S., Anderson, Rosaleen and Elkordy, Amal (2014) Norfloxacin as a model hydrophobic drug with unique release from liquisolid formulations prepared with PEG200 and Synperonic PE/L-61 non-volatile liquid vehicles. Powder Technology (257). pp. 156-167. (Submitted) Zhang, Weimin, Ning, Fuquiang, Varadi, Linda, Hibbs, David E., Platts, James A., Nyerges, Miklos, Anderson, Rosaleen and Groundwater, Paul (2014) An investigation of the scope of the 1,7-electrocyclization of α,b:γ,δ-conjugated azomethine ylides. Tetrahedron, 70 (22). pp. 3621-3629. ISSN 0040-4020 (In Press) Bedernjak, Alexandre, Groundwater, Paul, Gray, Mark, Orenga, S, Perry, J D and Anderson, Rosaleen (2013) Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria. Tetrahedron, 69 (39). pp. 8456-8462. ISSN 0040-4020 Alderton, W K, Anderson, Rosaleen, Collingwood, S P and Pryde, D C (2013) Therapeutic Opportunities in Infectious Diseases: Highlights from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, London, UK. Drugs of the Future, 38 (5). p. 347. ISSN 0377-8282