Georgetown University, B.S Biology 1987 University of Texas Southwestern Medical Center, Ph.D. Neuroscience, 1993 Columbia University College of Physicians and Surgeons, Aaron Diamond Post-Doctoral Fellow, 1993-1996 Experience Weill Cornell Medical College, New York, NY Assistant Professor of Biochemistry in Medicine, 1996-2004 Assistant Professor of Genetic Medicine, 2000-2004 Associate Professor of Genetic Medicine, 2004-2008 Associate Professor of Biochemistry in Medicine, 2004-2008

Intracellular trafficking of viruses

Gene therapy

Genetic diseases

Jubeli E, Raju L, Khalique NA, Bilchuk N, Zegel C, Chen A, Lou HH, �pstad CL, Zeeshan M, Sliwka HR, Partali V, Leopold PL, Pungente MD. (2015). "Polyene-based cationic lipids as visually traceable siRNA transfer reagents", European Journal of Pharmaceutics and Biopharmaceutics, 89 280-289.

Jia C, Yu D, Teng YD, Lamarre M, Leopold PL, Wang H.. (2014). "Patterned electrospun nanofiber matrices via localized dissolution: Potential for guided tissue formation", Advanced Materials, DOI: 10.1002/adma.201403509 .

�pstad CL, Zeeshan M, Sliwka H-R, Partali V, Surve C, Izower MA, Bilchuk N, Lou H, Larsen H, Nicholson D, Liberska A, Khalique NA, Raju L, Flinterman M, Jubeli E, Leopold PL, Pungente MD. (2014). "Synthesis and characterization of highly unsaturated, C30- and C20- carotenoid-based cationic phospholipids as DNA transfer reagents", Chemistry and Physics of Lipids, 183: 117-136.

�pstad CL, Sliwka HR, Partali V, Elgsaeter A , Leopold PL, Jubeli E, Khalique NA, Rajud L, Pungente MD. (2013). "Synthesis of a novel highly unsaturated, conjugated cationic phospholipid. ", Chemistry and Physics of Lipids, 170-171: 65-73.

Leopold PL, Vincent J, Wang H. (2012). "A comparison of epithelial-to-mesenchymal transition and re-epithelialization. ", Seminars in Cancer Biology, 22: 471-483.

Pungente MD, Jubeli E, �pstad C, Al-kawaz M, Barakat N, Ibrahim T, Khalique NA, Jones R, Leopold PL, Sliwka HR, Partali V. (2012). "Synthesis and preliminary investigations towards the siRNA delivery potential of novel, single-chain rigid cationic carotenoid lipids. ", Molecules, 17 3484-3500.

Leopold PL,* O�Mahony MJ,* Lian XJ,* Harvey BG, Crystal RG. (2009). "Smoking is associated with shortened airway cilia ", PLoS ONE, [* - these authors contributed equally to the work]. 4 (12), e8157.

Vincent T, Neve EPA, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J.. (2009). "A Snail-Smad transcriptional repressor complex promotes TGF-β-mediated epithelial-mesenchymal transition ", Nature Cell Biology, 11 943-950.

Berth SB, Leopold PL, Morfini G.. (2009). "Virus-induced neuronal dysfunction and degeneration. ", Frontiers in Bioscience, 14 5239-5259.

Kiuru M, Hidaka C, Hubner R-H, Krause A, Leopold PL, Crystal RG.. (2009). "Transient systemic overexpression of Sonic hedgehog mediates expansion of diaphyseal trabecular bone with associated amplification of the hematopoietic stem cell niche.", Molecular Therapy, 17 1442-1452.

Hubner R-H, Kiuru M, Krause A, Leopold PL, Crystal RG.. (2009). "Dysfunction in glycogen storage with metabolic consequences in a mouse model of Alpha 1-Antitrypsin Deficiency", Am. J. Resp. Cell Molec. Biol., 40 239-247.

Saitoh H, Leopold PL, Harvey B-G, O'Connor TP, Worgall S, Hackett NR, Crystal RG. (2009). "Emphysema Mediated by Lung Overexpression of ADAM10", Clin Transl Sci, 2 50-56.

Song Y, Lou HH, Boyer JL, Limberis MP, Vandenberghe LH, Hackett NR, Leopold PL, Wilson JM, Crystal RG. (2009). "Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing", Hum Gene Ther, 20 267-281.

Leopold PL, Crystal RG. (2007). "Intracellular trafficking of adenovirus: Many means to many ends", Advanced Drug Delivery Reviews, 59 810-821.

Leopold PL, Wendland R, Vincent T, Crystal RG. (2006). "Neutralized adenovirus-immune complexes can mediate effective gene transfer via a Fc receptor-dependent infection pathway", Journal of Virology, 80 10237-10247.

Leopold PL, Pfister KK. (2006). "Viral strategies for intracellular trafficking: motors and microtubules", Traffic, 7 516-523.

Kelkar S, De B, Gao G, Wilson JM, Crystal RG, Leopold PL. (2006). "A common mechanism for cytoplasmic dynein-dependent microtubule binding shared among adeno-associated virus and adenovirus serotypes", Journal of Virology, 80 7781-7785.

Lou H, Crystal RG, Leopold PL. (2005). "Enhanced in vivo efficacy of cholesterol-minus Sonic hedgehog", Molecular Therapy, 12 575-578.