Current Position at St. Jude Associate Member Department of Epidemiology and Cancer Control 09/2018 - Present Education and Training BSc in Molecular Biology, East China Normal University 07/1992 MSc in Mathematical Computer Science, University of Illinois at Chicago 08/2000 PhD in Computational Biology and Bioinformatics, George Mason University 08/2013 Professional Career Research Associate The Shanghai Institute of Plant Physiology Chinese Academy of Sciences Shanghai, China 7/1992 – 6/1997 Senior Software Developer JDA Software Inc.Rockville, MD 9/2000 – 12/2005 Senior Bioinformatics Analyst Cancer Genomics Research Laboratory Division of Cancer Genetics and Epidemiology National Cancer Institute Gaithersburg, MD 12/2005 – 10/2010 Group Leader, Bioinformatics Cancer Genomics Research Laboratory Division of Cancer Genetics and Epidemiology National Cancer Institute Gaithersburg, MD 10/2010 – 08/2015 Bioinformatics Scientist, SJLife Genomics Lead Department of Computational Biology 08/2015 – 09/2018 Associate Member Department of Computational Biology 09/2018 – 12/2019

Genetic epidemiology of cancers (primary, subsequent) Biomarker discovery for late effects of childhood cancer survivors Omics-based precision preventive medicine

Wang Z, Wilson CL, Armstrong GT, Hudson MM, Zhang J, Nichols KE, Robison LL. Association of germline BRCA2 mutations with the risk of pediatric or adolescent non-Hodgkin Lymphoma. JAMA Oncol. 2019 Jul 25;5(9):1362-1364. PubMed PMID: 31343663; PMCID: PMC6659356. Role: First author, corresponding author Yan C, Zhu M, Ding Y, Yang M, Wang M, Li G, Ren C, Huang T, Yang W, He B, Wang M, Yu F, Wang J,Zhang R, Wang T, Ni J, Chen J, Jiang Y, Dai J, Zhang E, Ma H, Wang Y, Xu D, Wang S, Chen Y, Xu Z, Zhou J, Ji G, Wang Z, Zhang Z, Hu Z, Wei Q, Shen H, Jin G. Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations. Gut. 2020 Apr;69(4):641-651. PubMed PMID: 31383772. Edmonson MN, Patel AN, Hedges DJ, Wang Z, Rampersaud E, Kesserwan CA, Zhou X, Liu Y, Newman S, Rusch MC, McLeod CL, Wilkinson MR, Rice SV, Soussi T, Taylor JP, Benatar M, Becksfort JB, Nichols KE, Robison LL, Downing JR, Zhang J. Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): A cloud-based platform for curating and classifying germline variants. Genome Res. 2019 Sep;29(9):1555-1565. PubMed PMID: 31439692; PMCID: PMC6724669. Song N, Li Z, Qin N, Howell CR, Wilson CL, Easton J, Mulder HL, Edmonson MN, Rusch M, Zhang J, Hudson MM, Yasui Y, Robison LL, Ness KK, Wang Z. Shortened leukocyte telomere length associates with 39 an increased prevalence of chronic health conditions among survivors of childhood cancer: A report from the St. Jude Lifetime Cohort. Clin Cancer Res. 2020 Jan 22 (Epub). PubMed PMID: 31969337. Role: Senior author, corresponding author Maciaszek JL, Oak N, Chen W, Hamilton KV, McGee RB, Nuccio R, Mostafavi R, Hines-Dowell S, Harrison L, Taylor L, Gerhardt EL, Ouma A, Edmonson MN, Patel A, Nakitandwe J, Pappo AS, Azzato EM, Shurtleff SA, Ellison DW, Downing JR, Hudson MM, Robison LL, Santana V, Newman S, Zhang J, Wang Z, Wu G,Nichols KE, Kesserwan CA. Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma. Cold Spring Harb Mol Case Stud. 2019 Oct;5(5). PubMed PMID: 31604778; PMCID: PMC6824257. Wang Z, Rice SV, Chang TC, Liu Y, Liu Q, Qin N, Putnam DK, Shelton K, Lanctot JQ, Wilson CL, Ness KK, Rusch MC, Edmonson MN, Wu G, Easton J, Kesserwan CA, Downing JR, Chen X, Nichols KE, Yasui Y, Robison LL, Zhang J. Molecular mechanism of telomere length dynamics and its prognostic value in pediatric cancers. J Natl Cancer Inst. 2019 Oct 24 (Epub). PubMed PMID: 31647544. Role: First author, corresponding author Wilson CL, Wang Z, Liu Q, Ehrhardt MJ, Mostafavi R, Easton J, Mulder H, Hedges DJ, Wang S, Rusch M,Edmonson M, Levy S, Lanctot JQ, Currie K, Lear M, Patel A, Sapkota Y, Brooke RJ, Moon W, Chang TC, Chen W, Kesserwan CA, Wu G, Nichols KE, Hudson MM, Zhang J, Robison LL, Yasui Y. Estimated number of adult survivors of childhood cancer in United States with cancer-predisposing germline variants. Pediatr Blood Cancer. 2020 Feb;67(2):e28047. PubMed PMID: 31736278; PubMed Central PMCID: PMC7065721. Sapkota Y, Cheung YT, Moon W, Shelton K, Wilson CL, Wang Z, Mulrooney DA, Zhang J, Armstrong GT, Hudson MM, Robison LL, Krull KR, Yasui Y. Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort Study. Clin Cancer Res. 2019 Nov 15;25(22):6700-6708. PubMed PMID: 31462438; PMCID: PMC6858960. Ma X, Shao Y, Tian L, Flasch DA, Mulder HL, Edmonson MN, Liu Y, Chen X, Newman S, Nikatandwe J, Li Y, Li B, Shen S, Wang Z, Shurtleff S, Robison LL, Levy S, Easton J, Zhang J. Analysis of error profiles in deep next-generation sequencing data. Genome Biol. 2019 Mar 14;20(1):50. PubMed PMID: 30867008; PMCID: PMC6417284. Sapkota Y, Turcotte LM, Ehrhardt MJ, Howell RM, Arnold MA, Wilson CL, Leisenring W, Wang Z, Sampson J, Dagnall CL, Karlins E, Li SA, Hicks BD, Weathers R, Smith SA, Shelton K, Liu Q, Tucker MA, Chanock SJ,Zhang J, Hudson MM, Neglia JP, Armstrong GT, Robison LL, Morton LM, Bhatia S, Yasui Y. Genome-wide association study in irradiated childhood cancer survivors identifies HTR2A for subsequent basal cell carcinoma. J Invest Dermatol. 2019 Sep;139(9):2042-2045.e8PubMed PMID: 30910758; PMCID: PMC6708785. Ehrhardt MJ, Howell CR, Hale K, Baassiri MJ, Rodriguez C, Wilson CL, Joshi SS, Lemond TC, Shope S, Howell RM, Wang Z, Srivastava DK, Mulrooney DA, Zhang J, Robison LL, Ness KK, Hudson MM. Breast cancer risk and detection in female childhood cancer survivors in the St. Jude Lifetime Cohort Study McMaster ML, Berndt SI, Zhang J, Slager SL, Li SA, Vajdic CM, Smedby KE, Yan H, Birmann BM, Brown EE, Smith A, Kleinstern G, Fansler MM, Mayr C, Zhu B, Chung CC, Park JH, Burdette L, Hicks BD, Hutchinson A, Teras LR, Adami HO, Bracci PM, McKay J, Monnereau A, Link BK, Vermeulen RCH, Ansell SM, Maria A, Diver WR, Melbye M, Ojesina AI, Kraft P, Boffetta P, Clavel J, Giovannucci E, Besson CM, Canzian F, Travis RC, Vineis P, Weiderpass E, Montalvan R, Wang Z, Yeager M, Becker N, Benavente Y,Brennan P, Foretova L, Maynadie M, Nieters A, de Sanjose S, Staines A, Conde L, Riby J, Glimelius B, Hjalgrim H, Pradhan N, Feldman AL, Novak AJ, Lawrence C, Bassig BA, Lan Q, Zheng T, North KE, Tinker LF, Cozen W, Severson RK, Hofmann JN, Zhang Y, Jackson RD, Morton LM, Purdue MP, Chatterjee N, Offit K, Cerhan JR, Chanock SJ, Rothman N, Vijai J, Goldin LR, Skibola CF, Caporaso NE. Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia. Nat Commun. 2018 Oct10;9(1):4182. PubMed PMID: 30305637; PMCID: PMC6180091. Ostrom QT, Kinnersley B, Armstrong B, Armstrong G, Rice T, Chen Y, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Berstein JL, Claus EB, Eckel-Passow JE, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Rubin JB, Andersson U, Rajaraman P, Chanock SJ, Linet 37 MS, Wang Z, Yeager M, GliomaScan Consortium, Houlston RS, Jenkins RB, Wrensch MR, Melin B, Bondy ML, BArnholtz-Sloan JS. Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age. Int J Cancer. 2018 Nov 15;143(10):2359-2366 PubMed PMID: 30152087; PMCID: PMC6205887. Wang Z, Liu Q, Wilson CL, Easton J, Mulder H, Chang TC, Rusch MC, Edmonson MN, Rice SV, Ehrhardt MJ, Howell RM, Kesserwan CA, Wu G, Nichols KE, Downing JR, Hudson MM, Zhang J, Yasui Y, Robison LL. Polygenic determinants for subsequent breast cancer risk in survivors of childhood cancer: The St Jude Lifetime Cohort Study (SJLIFE). Clin Cancer Res. 2018 Dec 15;24(24):6230-6235. PubMed PMID: 30366939; PMCID: PMC6295266. Role: First author, corresponding author Ma X, Liu Y, Liu Y, Alexandrov LB, Edmonson MN, Gawad C, Zhou X, Li Y, Rusch MC, Easton J, Huether R, Gonzalez-Pena V, Wilkinson MR, Hermida LC, Davis S, Sioson E, Pounds S, Cao X, Ries RE, Wang Z, Chen X, Dong L, Diskin SJ, Smith MA, Guidry Auvil JM, Meltzer PS, Lau CC, Perlman EJ, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J. Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. Nature. 2018 Mar 15;555(7696):371-376. PubMed PMID: 29489755; PMCID: PMC5854542. Wang Y, Gray DR, Robbins AK, Crowgey EL, Chanock SJ, Greene MH, McGlynn KA, Nathanson K, Turnbull C, Wang Z, Devoto M, Barthold JS; Testicular Cancer Consortium. Subphenotype meta-analysis of testicular cancer genome-wide association study data suggests a role for RBFOX family genes in cryptorchidism susceptibility. Hum Reprod. 2018 May 1;967-977. PubMed PMID: 29618007; PMCID: PMC5925768. Ostrom QT, Kinnersley B, Wrensch MR, Eckel-Passow JE, Armstrong G, Rice T, Chen Y, Wiencke JK, McCoy LS, Hansen HM, Amos CI, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Rubin JB, Lathia JD, Berens ME, Andersson U, Rajaraman P, Chanock SJ, Linet MS, Wang Z, Yeager M; GliomaScan consortium, Houlston RS, Jenkins RB, Melin B, Bondy ML, Barnholtz-Sloan JS. Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. Sci Rep. 2018 May 9;8(1):7352. PubMed PMID: 29743610; PMCID: PMC5943590. Wang Z, Wilson CL, John Easton, Thrasher A, Mulder H, Qi Liu, Hedges DJ, Wang S, Rusch M, Edmonson M, Levy S, Lanctot JQ, Caron E, Shelton K, Currie K, Lear M, Patel A, Rosencrance C, Shao Y, Vadodaria B, Yergeau D, Sapkota Y, Brooke RJ, Moon W, Rampersaud E, Ma X, Chang TC, Rice SV, Pepper C, Zhou X, Chen X, Chen W, Jones A, Boone B, Ehrhardt MJ, Krasin MJ, Howell RM, Phillips NS, Lewis C, Srivastava D, Pui CH, Kesserwan CA, Wu G, Nichols KE, Downing JR, Hudson MM, Yasui Y, Robison LL, Zhang J. Genetic risk for subsequent neoplasms among long-term survivors of childhood cancer. J Clin Oncol. 2018 Jul 10;36(20):2078-2087. PubMed PMID: 29847298; PMCID: PMC6036620. Role: First author Brooke RJ, Im C, Wilson CL, Krasin MJ, Liu Q, Li Z, Sapkota Y, Moon W, Morton LM, Wu G, Wang Z, Chen W, Howell RM, Armstrong GT, Bhatia S, Mostoufi-Moab S, Seidel K, Chanock SJ, Zhang J, Green DM, Sklar CA, Hudson MM, Robison LL, Chemaitilly W, Yasui Y. A high-risk haplotype for premature menopause in childhood cancer survivors exposed to gonadotoxic therapy. J Natl Cancer Inst. 2018 Aug 1;110(8):895-904. PubMed PMID: 29432556; PMCID: PMC6093389.