B.A., Beloit College Ph.D., Harvard University

HIV Virology and Immunology

The research in our laboratory uses molecular and cell biology methods to investigate key questions at the interface of virology, pathogenesis, and the human cellular immune response to human immunodeficiency virus (HIV) infection. Ongoing studies aim to understand the impact of viral immune escape mutations on HIV protein function and cytotoxic T lymphocyte (CTL) recognition, to assess the role of HIV accessory proteins in establishment and maintenance of viral latency, and to employ new assays to identify patient-derived T cell receptors (TCR) that display enhanced ability to recognize HIV-infected cells.

Kuang et al. Impaired Nef function is associated with early control of HIV-1 viremia. Journal of Virology, 2014 Anmole et al. A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion. J Immunol Methods 2015 (doi: 10.1016/j.jim.2015.08.010) Brockman et al. Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs. Front Immunol 2015 (doi: 10.3389/fimmu.2015.00506)