Education and Experience B.S. Chemistry, Yonsei University, Korea, 1993 M.S. Chemistry, Yonsei University, Korea, 1997 Ph.D. Chemistry, Texas A＆M University, USA, 2001

Research Experiences Postdoctoral Research Fellow, Harvard University, 2001-2004

BIO/ORG

Current Research Interests The main focus of my research is the identification and development of new bioactive chemical properties, which allow us to study the complex biological system as well as to utilize the new properties as potential therapeutic agents (drugs), through interdisciplinary approaches; Organic Chemistry, Bioassay, and Chemical Biology.

Design and synthesis of diverse and complex small molecules through Diversity Oriented Synthesis (DOS)

Development of new high-throughput screening for biological evaluation

Chemical Biology for the Application of identified bioactive small molecules

Deconvolution of Specific and Nonspecific Protein Targets using Proteome-Labeling Profiles of Photoaffinity Linkers. Park, J.; Koh, M.; Koo, J. Y.; Lee, S.; Park, S.B.* submitted. Unique Photophysical Properties of 9-Styryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one and Their Efficient Synthesis via Direct C-H Activation. Choi, E.; Park, S.B.* Chemical Science 2015 in revision. Nuclear Receptor ERRg Regulates Alcohol-Induced Oxidative Stress through Induction of CYP2E1. Lee, J. H.; Kim, E.-J.; Kim, D.-K.; Lee, J.-M.; Park, S.B.; Lee, I.-K.; Harris, R. A.; Lee, M.-O.*; Choi, H.-S.* PLoS ONE 2015 in revision. (IF: 3.730) Discovery of In Vivo Effective Anti-virulence Agent of Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR from Phenotype-Based Elastase Inhibitor Screening. Kim, S.M.; Park, J.; Kim, B.; Kim, M.S.; Song, H.; Jo, A.; Park, H.; Kim, T.S.*; Choi, S.H.*; Park, S. B.* 2015 submitted Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Kim, J.I.; Huh, J.Y.; Sohn, J.H.; Choe, S.S.; Lee, Y.S.; Lim, C.Y.; Jo, A.; Park, S.B.; Han, W.; Kim, J.B. Mol. Cell. Biol. 2015, doi:10.1128/MCB.01321-14 Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor. Kim, E.; Lee, Y.; Lee, S.; Park, S.B.* Acc. Chem. Res. 2015, Accepted. DOI: 10.1021/ar500370v (IF: 24.348) Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces. Kim, J.; Kim, H.; Park, S.B.* J. Am. Chem. Soc. 2014 136(42), 14629–14638 Discovery of carbohybrid-based 2-aminopyrimidine analogues as multi-stage active antimalarial agents using image-based cytological profiling assay. Lee, S.; Lim, D.; Lee, E.; Lee, N.; Lee, H.-G.; Cechetto, J.; Liuzzi, M.; Freitas-Junior, L.H.; Song, J.S.; Bae, M.A.; Oh, S.; Ayong, L.*; Park, S.B.* J. Med. Chem. 2014 57(17), 7425–7434. Target Identification Revealed a Direct HMGB2-binding Small Molecule with an Anti-neuroinflammatory Effect. Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Suk, K.*; Park, S.B.* Nature Chemical Biology 2014 10(12), 1055–1060. (IF: 13.217). A novel non-agonistic PPARγ ligand, CDK104 blocks PPARγ phosphorylation by CDK5 and improves insulin sensitivity. Choi, S.-S.; Kim, E.S.; Koh, M.; Lee, S.-J.; Lim, D.; Yang, Y.R.; Jang, H.-J.; Park, S.B.; Suh, P.-G.; Choi, J.H.* J. Biol. Chem. 2014 289(38), 26618–26629. Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3. Park, J.; Um, J.I.; Jo, A.; Lee, J.; Jung, D.-W.; Williams, D.*; Park, S. B.* Chem. Commun. 2014 50(66), 9251–9254 Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy. Koh, M.; Park, J.; Koo, J.Y.; Lim, D.; Cha, M.Y.; Jo, A.; Choi, J.H.; Park, S. B.* Angew. Chem. Int. Ed. 2014, 53(20), 5102–5106 Inverse agonist of ERRgamma controls Salmonella typhimurium infection by modulating host iron homeostasis. Kim1, D.-K.; Jeong, J.-H.; Lee, J.-M.; Kim, K.S.; Park, S.-H.; Kim, Y.D.; Koh, M.; Shin, M.; Jung, Y.S.; Kim, H.-S.; Lee, T.-H.; Oh, B.-C.; Kim, J. I.; Park, H.T.; Jeong, W.-I.; Lee, C.-H.; Park, S.B.; Min, J.-J.; Jung, S.-I.; Choi, S.-Y.; Choy, H.E.*; Choi, H.-S.* Nature Medicine 2014, 20, 419–424. (IF: 22.864) Anti-inflammatory effects of a-galactosylceramide analogs in activated microglia; involvement of p38 MAPK signaling pathway. Jeong, Y.-H.; Kim, Y.; Song, H.; Park, S.B.*; Kim, H.-S.* PLoS ONE 2014 9(2), e87030 (IF: 3.730) Rational Perturbation of Fluorescence Quantum Yields in Emission-tunable and predictable Fluorophores, Seoul-Fluors, via Facile Synthesis using C-H Activation. Choi, E.; Kim, E.; Lee, Y.; Jo, A.; Park, S. B.* Angew. Chem. Int. Ed. 2014 53(5), 1346-1350 (IF: 13.734) Synthesis and Library Construction of privileged tetra-substituted ∆5-2-oxopiperazine as β-turn structure mimetics. Kim, J.; Lee, W. S.; Koo, J.; Lee, J.; Park, S. B.* ACS Combinatorial Sciences 2014 16(1), 24–32 (IF: 3.636) Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4. Kwon, D.H.; Eom, G.H.; Kim, D.K.; Koo, J.; Lim, H.S.; Nam, G.-I.; Kim, K.K.; Lee, I.-K.; Park, S.B.; Choi, H.-S.; Kook, H.* Journal of Molecular and Cellular Cardiology 2013 65, 88-97 (IF: 5.150) Privileged Substructure-Based Diversity-Oriented Synthesis Pathway for Diverse Pyrimidine-Embedded Polyheterocycles. Kim, H.; Tung, T. T.; Park, S. B.* Org. Lett. 2013 15(22), 5814–5817(IF: 6.142) Measurement of Accumulation Kinetics for Lipid Droplets in Microalgae using SF44. Park, J.W.; Na, S. C.; Lee, Y.; Lee, S.; Park, S. B.*; Jeon, N.R.* Energies 2013 6(11), 5703–5716 (IF: 1.844)

Synthesis and Biological Evaluation of α-Galactosylceramide Analogues with Heteroaromatic Rings and Varying Positions of Phenyl Group in the Sphingosine Backbone. Kim, Y.; Oh, K.; Song, H.; Lee, D.-S.; Park, S. B.* J. Med. Chem. 2013 56(17), 7100–7109(IF: 5.614)