Mario Wiesenfeldt was born in Ludwigshafen am Rhein and studied chemistry at the Ruprecht Karls-Universität Heidelberg, where he worked with Prof. Lutz Gade. Following an exchange semester at the University of York, Mario conducted the research towards his master thesis in the group of Prof. Brian Stoltz at the California Institute of Technology. In 2015, Mario joined the group of Prof. Frank Glorius at the WWU Münster to develop selective arene hydrogenation reactions before moving to Princeton in 2019 to conduct a postdoctoral stay in the group of Prof. David MacMillan. In the MacMillan group, he developed new syntheses of bioisosteres and functionalizations thereof via photoredox catalysis. In October 2021, Mario started his independent career at the RU Bochum and at the MPI für Kohlenforschung. Career From 2021 Independent Career at RU Bochum/ MPI für Kohlenforschung 2019–2021 Postdoctoral Research Prof. Dr. D. W. C. MacMillan, Princeton University 2015–2019 PhD in Organic Chemistry Prof. Dr. F. Glorius, WWU Münster 2009–2015 B.Sc and M.Sc. Studies Ruprecht-Karls-Universität Heidelberg Master Thesis with Prof. Dr. B. M. Stoltz, California Institute of Technology Exchange semester at the University of York Selected Awards 2022 Thieme Chemistry Journals Award 2021 Liebig scholarship by the Fonds der Chemischen Industrie 2021 GDCH Prize for university innovation 2019 Postdoctoral scholarship by the German National Academy of Sciences Leopoldina 2018 WWU Dissertation Prize 2018 Evonik Prize 2016 PhD scholarship by the Studienstiftung des Deutschen Volkes 2014 PROMOS scholarship 2013 European Talent Pool of the BASF SE 2013 Deutschlandstipendium

The Wiesenfeldt Lab is a newly established research group at the Ruhr-Universität Bochum and at the Max-Planck-Institut für Kohlenforschung. We develop synthetic organic methods via radical intermediates with a focus on transformations that address synthetic problems in medicinal chemistry. We are particularly interested in providing selective access to radicals via excitation of electron-donor-acceptor (EDA) complexes and have used these species for the development of mild organophotocatalytic reduction reactions. Physical organic chemistry plays a major role in our research regarding the formation and decomposition pathways of excitet state intermediates, and solvent effects on their rate constants. As such, students in the Wiesenfeldt Lab will work on cutting-edge transformations with a focus on radical chemistry and photocatalysis, and be exposed to a diverse set of topics ranging from physical organic chemistry to medicinal chemistry.

J. Am. Chem. Soc. 2024, 10.1021/jacs.4c14669 Organophotocatalytic reduction of benzenes to cyclohexenes K. Devi,§ A. Shehzad,§ M. P. Wiesenfeldt* Chemrxiv 2024, DOI: 10.26434/chemrxiv-2024-gj19b Z-Selective alkyne transfer semihydrogenation in Drug-Like Molecules via an Organic Photoreductant B. R. G. Bissinger,§ D. H. Vu,§ H. F. Janning, M. P. Wiesenfeldt* Nature Protocols 2024, 19, 1529–1556 Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy G. Heinrich, M. Kondratiuk, L. J. Gooßen, M. P. Wiesenfeldt* Nature 2023, 618, 513–518 General Access to Cubanes as Benzene Bioisosteres M. P. Wiesenfeldt,§ J.A. Rossi-Ashton,§ I. B. Perry,§ J. Diesel, O. Garry, F. Bartels, S. C. Coote, X. Ma, C. S. Yeung, D. J. Bennett, D. W. C. MacMillan* Chem. Sci. 2021, 12, 5611–5615 Enantioselective hydrogenation of annulated arenes: controlled formation of multiple stereocenters in adjacent rings M. P. Wiesenfeldt,§ D. Moock,§ D. Paul,§ F. Glorius* J. Phys. Chem. B 2021, 125, 3700–3709 Polarity matters: dielectric relaxation in all-cis-multifluorinated cycloalkanes A. Theodoridis, G. Papamokos, M. P. Wiesenfeldt, M. Wollenburg, K. Müllen, F. Glorius*, G. Floudas* ACS Catal. 2020, 10, 6309–6317 Mechanistic understanding of the heterogeneous, rhodium-cyclic (alkyl)(amino)carbene-catalyzed (fluoro-)arene hydrogenation D. Moock, M. P. Wiesenfeldt,§ M. Freitag,§ S. Muratsugu, S. Ikemoto, R. Knitsch, J. Schneidewind, W. Baumann, A. H. Schäfer, A. Timmer, M. Tada, M. R. Hansen, F. Glorius* Angew. Chem. Int. Ed. 2019, 58, 10460–10476 Selective arene hydrogenation for direct access to saturated carbo- and heterocycles M. P. Wiesenfeldt, Z. Nairoukh, T. Dalton, F. Glorius* Angew. Chem. Int. Ed. 2018, 57, 8297–8300 Silylarene hydrogenation: a strategic approach that enables direct access to versatile silylated saturated carbo- and heterocycles M. P. Wiesenfeldt, T. Knecht, C. Schlepphorst, F. Glorius* Chem. Eur. J. 2018, 24, 356–359 Enantioselective hydrogenation of imidazo[1,2-a]pyridines C. Schlepphorst, M. P. Wiesenfeldt, F. Glorius* Science 2017, 357, 908–912 Hydrogenation of fluoroarenes: direct access to all-cis-(multi)fluorinated cycloalkanes M. P. Wiesenfeldt, Z. Nairoukh, W. Li, F. Glorius* J. Am. Chem. Soc. 2017, 139, 2585–2588 Ruthenium−NHC−diamine catalyzed enantioselective hydrogenation of isocoumarins W. Li, M. P. Wiesenfeldt, F. Glorius* Org. Synth. 2015, 92, 247–266 Preparation of (S)-tert-ButylPyOx and palladium-catalyzed asymmetric conjugate addition of arylboronic acids J. C. Holder, S. E. Shockley, M. P. Wiesenfeldt, H. Shimizu, B. M. Stoltz*