B.S. Chemistry/Sensors & Devices (1982) California Polytechnic State University Ph.D. Physical/Materials Chemistry (1987) Stanford University

A long-standing research interest of the McDevitt group is the science and engineering of hybrid molecular assemblies as applied to sensor and device applications. Research efforts are underway to translate these discoveries into forms that are practical and scalable for use as real-world sensors for humanitarian and civilian applications. These highly sensitive and selective sensor systems have begun to serve as powerful diagnostic tools that have enabled new clinical studies to be completed that were not previously thought possible. The following are brief summaries of the activities currently in progress in the McDevitt laboratories that utilize these novel nano-bio-chip platform systems.

CARDIUS (Cardiac Arrest Rapid Diagnostic Information Using Saliva) According to a recent report by the American Heart Association (Rosamond et al. Circulation, 117 (4): 2008), cardiovascular disease remains the leading cause of death in developed countries. Coronary artery disease (CAD), the precursor to many heart attacks, causes 1 of every 5 deaths in the United States. In 2008, an estimated 770,000 Americans had a new coronary attack, and about 430,000 are expected to have a recurrent attack within the next year.

Leveraging microelectronics components and microfabrication developed initially for the electronic industry, the McDevitt laboratory and collaborators have developed a series of compact nano-bio-chip sensor devices that are cost effective and yield ultra-powerful diagnostic capabilities. The nano-bio-chip sensors are biochemically programmable and, as such, can be fashioned to detect numerous proteins in saliva that offer diagnostic utility. Recent activities have led to the identification of diagnostic panels for identifying a patient’s risk for primary cardiac events as well as for diagnosing an actual heart attack when it happens. This CARDIUS technology, which contains all necessary reagents on a device the size of a credit card, produces equivalent results to clinical laboratory blood tests in as little as 15 minutes using a few drops of saliva.

Y. S. Sohn, A. Goodey, E. V. Anslyn, J. T. McDevitt, J. B. Shear, D. P. Neikirk A Micromachined Fluidic Structure for Capillary-Based Sample Introduction into a Microbead Array Chemical Sensor. Sens. Lett., 2: 69-72 A. Raamanathan, N. Christodoulides, G. Simmons, P. N. Floriano, W. Furmaga, S. Redding, K. H. Lu, R. C. Bast, J. T. McDevitt Bio-Nano-Chip Immunosensor for Serum Ca125 Quantification: Towards Ovarian Cancer Diagnostics at the Point-of-Care. Lab on a Chip W. V. Giannobile, J. T. McDevitt, R. S. Niebala, D. Malamud Clinical Frontiers: Translational and Clinical Applications of Saliva Diagnostics. Journal of Dental Research Y. S. Sohn, A. P. Goodey, E. V. Anslyn, J. T. McDevitt, J. B. Shear, D. P. Neikirk Development of Micromachined Fluidic Structure for a Biological and Chemical Sensor Array. Kluwer Academic Publisher: 177-178 S. E. Weigum, P. N. Floriano, N. Christodoulides, S. Redding, C. Yeh, N. Vigneswaran, M. D. Williams, J. T. McDevitt Diagnostic Tool Performing Cytology-on-a-Chip Aids Oral Cancer Detection. SPIE Newsroom M. F. Ali, J. Chou, P. N. Floriano, N. Christodoulides, J. T. McDevitt Modular Nucleic Acid Sensors: Incorporation of Molecular Beacon Probes within the Programmable Bio-Nano-Chip System. Anal. Chem. L. P. Grazett, D. Paltoo, J. T. McDevitt, S. Sia, P. Barrett, F. Apple, P. Gurbel, R. Weissleder, H. Leeds, E. Iturriaga, A. Rao, B. Adhikari, P. Desvigne-Nickens, Z. Galis, P. Libby Onsite Tools and Technologies for Clinical Cardiovascular Research and Point-of-Care: National Heart, Lung, and Blood Institute (NHLBI) Working Group. Journal of the American College of Cardiology: Submitted I.M. Thompson, J. Hernandez, R.J. Leach, S. Bock, J. Hoefler, Z. Feng, J. Kagan, N. Christodoulides, A. Haque, J.T. McDevitt, T. Huang, D. Ankerst, "PSA and Prostate Cancer Early Detection: Targeting Detection of Consequential Prostate Cancers", 2013, Submitted. D. Kirillov, J. P. Collman, J. T. McDevitt, G. T. Yee, M. J. Holcomb, I. Bozovic Raman-Spectra of Yba2cu3ox Superconductors with Different Oxygen-Content. Phys. Rev. B, 37: 3660-3663 W. V. Giannobile, J. T. McDevitt, R. S. Niedbala, D. Malamud Translation and Clinical Applications of Salivary Diagnostics. Advances in Dental Research, 23: 375-380 J.T. McDevitt Bio-Nano-Chip Devices May Open up New Oral Diagnostics Opportunities. International Journal of Experimental Dental Science 2012: In Press J. Chou, L. Li, N. Christodoulides, P. N. Floriano, J. T. McDevitt Effects of Sample Delivery on Analyte Capture in Porous Bead Sensors. Lab on a Chip, 12 2012: 5249-5256 J. Chou, N. Du , T. Ou , P.N. Floriano, N. Christodoulides, J.T. McDevitt Hot embossed polyethylene through-hole chips for bead-based microfluidic devices . Biosens. Bioelectron. , 12 2012: 662-8 N. Christodoulides, P. N. Floriano, J. T. McDevitt Innovative Programable Bio-Nano-Chip (P-Bnc) Technology: Bridging the Gap between Biomarker Discovery and Clinical Implementation. IEEE Transactions on Biomedical Engineering 2012: Submitted J. Chou, A. Lennart, J. Wong, M. F. Ali, P. N. Floriano, N. Christodoulides, J. T. McDevitt Modeling Analyte Transport and Capture in Porous Bead Sensors. Anal. Chem., 84 2012: 2569-2575 J. Chou, A. Lennart, J. Wong, M. F. Ali, P. N. Floriano, N. Christodoulides Modeling Analyte Transport and Capture in Porous Bead Sensors. Anal. Chem., 84 2012: 2569-2575 J.D. 3rd Foley, J.D. Sneed, S.R. Steinhubl, J. Kolasa, J.L. Ebersole, Y. Lin, R.J. Kryscio, J.T. McDevitt, C.L. Campbell, C.S. Miller Oral fluids that detect cardiovascular disease biomarkers . Oral Surg Oral Med Oral Pathol Oral Radiol, 2 2012: 207-14 E. Fu, P. Yager, P. N. Floriano, N. Christodoulides, J. T. McDevitt Perspective on Diagnostics for Global Health. IEEE Pulse, 2 2012: 40-50 J. Chou, J. Wong, N. Christodoulides, P. N. Floriano, G. W. Simmons, X. Sanchez, J. T. McDevitt Porous Bead-Based Diagnostic Platforms: Bridging the Gaps in Healthcare. Sensors, 11 2012: 15467-99 A. Raamanathan, G. W. Simmons, N. Christodoulides, P. N. Floriano, W. B. Furmaga, S. P. Redding, K. H. Lu, R. C. Bast, J. T. McDevitt Programmable Bio-Nano-Chip Systems for Serum Ca125 Quantification: Towards Ovarian Cancer Diagnostics at the Point-of-Care. Cancer Prevention Research, 5 2012: 706 A. Raamanathan, G. W. Simmons, N. Christodoulides, P. N.