B.S. in Biochemistry (High Honors), University of Maryland, College Park Mentors: Drs. John W. Kozarich and Bruce B. Jarvis Ph.D. in Microbiology & Immunology, UCLA Mentor: Dr. Jeff F. Miller Post-Doc, UC-San Diego Mentor: Dr. Jack E. Dixon

*Mattoo, S., Durant, E., Chen, M., Xiao, J., Manning, G., Dixon, J. E., *Worby, C. A. 2011. Comparative analysis of H. somni IbpA with other Fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. Journal of Biological Sciences. 286: 32834. *Corresponding author. Zekaris, B., Mattoo, S., Worby, C. A., Lehmann, J., Rosenbusch, R. F., Corbell, L. B. 2010. The Histophilus somni ibpA DR2/Fic Domain disrupts the natural host alveolar epithelial barrier. Infection & Immunity. 78: 1850. Selected as a "Spotlight" article by Infection & Immunity. Sukumar, N., Parise-Sloan, G., Conover, M. S., Love, C. F., Mattoo, S., Kock, N. D., Deora, R. 2010. Cross-species protection mediated by a Bordetella bronchiseptica strain lacking antigenic homologs present in the acellulat pertussis vaccines. Infection & Immunity. 78: 2008. Xiao, J., Worby, C. A., Mattoo, S., Sankaran, B., Dixon, J. E. 2010. Structural basis of Fic domain mediated adenylyation. nature Structural and Molecular Biology. 17: 1004. Faculty of 1000 Score 8. Medhekar, B., Shrivastava, R., Mattoo, S., Gingery, M., Miller, J. F. 2009. Bordetella Bsp22 defines a new family of T3SS tip complex proteins. Molecular Microbiology. 17: 492. *Worby, C. A., *Mattoo, S., Kruger, R. P., Corbell, L. B., Koller, A., Mendez, J. C., Zekarias, B., Lazar, C. S., Dixon J. E. 2009. The Fic domain: Regulation of cell signaling by adenylyation. Molecular Cell. 34: 93. *Equal contribution, Selected as "Editors Choice" article by Science, Selected as "Research Highlights" article by Nature Reviews Molecular Cell Biology, Faculty of 1000 Score 10. Mattoo, S., Alto, N. M., Dixon, J. E. 2008. Subversion of myosin function by E coli. Developmental Cell. 14: 8. Gentry, M. S., Dowen III, R. H., Worby, C. A., Mattoo, S., Ecker, J. R., Dixon, J. E. 2007. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. The Journal of Cell Biology. 178: 477. Alto, N. M., Shao, F., Lazar, C. S., Brost, R. L., Chua, G., Mattoo, S., McMahon, S. A., Ghosh, P., Hughes, T. R., Boone, C., Dixon, J. E. 2006 . Identification of a bacterial type III effector family with G-protein mimicry functions. Cell. 124: 133. Faculty of 1000 Score 29. Mattoo, S., Cherry, J. 2005. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella suspecies. Clinical Reviews in Microbiology. 8: 326. Kozak, N. A., Mattoo, S., Foreman-Wykert, A. K., Whitelegge, J. P., Miller, J. F. 2005. Interactions between partner switcher orthologs BtrW and BtrV regulate type III secretion in Bordetella. J Bacteriology. 187: 5665. Panina, E. M., Mattoo, S., Griffith, N., Kozak, N. A., Yuk, M. H., Miller, J. F. 2005. A genome-wide screen identifies a Bordetella type III secretion effector and candidae effectors in other species. Molecular Microbiology. 58: 267. Mattoo, S., Yuk, M. H., Huang, L. L., Miller, J. F. 2004. Regulation of type III secretion in Bordetella. Molecular Microbiology. 52: 1201. Top 50 most frequently targeted papers in Molecular Microbiology on-line via Synergy in 2004. Irie, Y., Mattoo, S., Yuk, M. H. 2004. The Bvg virulence control system regulates biofilm formation in Bordetella bronchiseptica. J. Bacteriology. 186: 5692. Mattoo, S., Foreman-Wykert, A. K., Cotter, P. A., Miller, J. F. 2001. Mechanisms of Bordetella pathogenesis. Frontiers in Bioscience. 6: 168. Mattoo, S., Miller, J. F., Cotter, P. A. 2000. Role of Bordetella bronchiseptica fimbriae in tracheal colonization and development of a human immune response. Infection & Immunity. 68: 2024. Cotter, P. A., Mattoo, S., Yuk, M. H., Akerley, B. J., et al. 1998. Filamentous hemagglutinin of Bordetella bronchiseplica is required for effecient establishment of tracheal coloniztion. Infection & Immunity. 66: 5921. Mazur, P., Henzel, W. J., Mattoo, S., Kozarich, J. W. 1994. 3-carboxy-cis, cis-musconate lactonizing enzyme from Neurospora crassa: An alternate cycloisomerase motif. J. Bacteriology. 176: 1718.