Honors 2024 – ACS Bader Award in Bioorganic or Bioinorganic Chemistry, 2022 – Ivano Bertini Award, International Conference on Copper Biology 2021 – Guggenheim Fellowship 2020 – Humboldt Award 2019 – Sackler Prize in Chemistry 2018 – RSC Jeremy Knowles Award 2017 – Elected Fellow, American Academy of Arts and Sciences 2016 – Cruickshank Award, Gordon Research Conferences 2015 – Fellow, Royal Society of Chemistry 2015 – Blavatnik National Award in Chemistry 2014 – Sackler Professor, UC Berkeley/UCSF 2013 – Baekeland Award, ACS New Jersey Section 2013 – Noyce Prize for Excellence in Undergraduate Teaching, UC Berkeley 2013 – ACS Nobel Laureate Signature Award in Graduate Education 2012 – RSC Chemistry of Transition Metals Award 2012 – ACS Eli Lilly Award in Biological Chemistry 2011 – Wilson Prize, Harvard University 2011 – Miller Institute Professor, UC Berkeley 2011 – Society for Biological Inorganic Chemistry Early Career Award 2010 – ACS Cope Scholar Award 2009 – Novartis Early Career Award 2009 – Astra Zeneca Excellence in Chemistry Award 2008 – Howard Hughes Medical Institute Investigator 2008 – Technology Review TR35 Young Innovator 2008 – Bau Award in Inorganic Chemistry 2008 – Hellman Faculty Award 2008 – Amgen Young Investigator Award 2008 – Paul Saltman Award, Metals in Biology Gordon Research Conference 2007 – Sloan Fellowship 2006 – Packard Fellowship 2006 – NSF CAREER Award 2005 – Beckman Young Investigator 2005 – American Federation for Aging Research Award 2004 – Dreyfus New Faculty Award

Our laboratory studies the chemistry and biology of the elements. We advance new concepts in imaging, proteomics, drug discovery, and catalysis by drawing from core disciplines of inorganic, organic, and biological chemistry. For example, we have developed activity-based sensing as a general platform to identify transition metals, reactive oxygen species, and one-carbon units as new classes of single-atom signals for allosteric regulation of protein function. These chemical tools also reveal unique metal and redox disease vulnerabilities as targets for innovative drug discovery efforts to treat neurodegeneration, cancer, and metabolic disorders. Representative project areas are summarized below. Transition Metal Signaling: Bioinorganic Chemistry of the Brain and Body. Activity-Based Sensing: Illuminating One- and Two-Carbon Signaling. Activity-Based Proteomics: Decoding and Drugging Single-Atom Signaling.

“Oxidative cyclization reagents reveal tryptophan cation-pi interactions”, Xie, X.; Moon, P. J.; Crossley, S. W. M.; Bischoff, A. J.; He, D.; Li, G.; Dao, N.; Gonzalez-Valero, A.; Reeves, A. G.; McKenna, J. M.; Elledge, S. K.; Wells, J. A.; Toste, F. D.*; Chang, C. J.* Nature 2024, 627, 680-687. “Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism”, Pham, V. N.; Bruemmer, K. J.; Toh, J. D.; Ge, E. J.; Tenney, L.; Ward, C. C.; Dingler, F. A.; Millington, C. L.; Garcia-Prieto, C. A.; Pulos-Homes, M. C.; Ingolia, N. T.; Bontel, L. B.; Esteller, M.; Patel, K. J.; Nomura, D. K.; Chang, C. J.* Science 2023, 382, 1-10. “Oxidation state-specific fluorescent copper sensors reveal oncogene-driven redox changes that regulate labile copper(II) pools”, Pezacki, A. T.; Matier, C. D.; Gu, X,; Kummelstedt, E.; Bond, S. E.; Torrente, L; Jordan-Sciutto, K. L.; DeNicola, G. M.; Su, T. A.; Brady, D. C.; Chang, C. J.* Proc. Natl. Acad. Sci. USA 2022, 119, e2202736119. “A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling”, Iwashita, H.; Castillo, E.; Messina, M. S.; Swanson, R.A.; Chang, C. J.* Proc. Natl. Acad. Sci. USA 2021, 118, e2018513118. “Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism”, Chung, C. Y.; Posimo, J. M.; Lee, S.; Tsang, T.; Davis, J. M.; Brady, D. C.; Chang, C. J.* Proc. Natl. Acad. Sci. USA 2019, 116, 18285-18294. “Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system”, Xiao, T.; Ackerman, C. M.; Carroll, E. C.; Jia, S.; Hoagland, A.; Chan, J.; Thai. B.; Liu, C. S.; Isacoff, E. Y.; Chang, C. J.* Nature Chem. Biol. 2018, 14, 655-663. “Redox-based reagents for chemoselective methionine bioconjugation”, Lin, S.; Yang, X.; Jia, S.; Weeks, A. M.; Hornsby, M.; Lee, P. S.; Nichiporuk, R. V.; Iavarone, A. T.; Wells, J. A.; Toste, F. D.; Chang, C. J.* Science 2017, 355, 597-602. “Copper regulates cyclic-AMP-dependent lipolysis”, Krishnamoorthy, L.; Cotruvo Jr., J. A.; Chan, J.; Kaluarachchi, H.; Muchenditsi, A.; Pendyala, V. S.; Jia, S.; Aron, A. T.; Ackerman, C. M.; Wander Wal, M. N.; Guan, T.; Smaga, L. P.; Farhi, S. L.; New, E. J.; Lutsenko, S.;Chang, C. J.* Nature Chem. Biol. 2016, 12, 586-593. “In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease”, Heffern, M. C.; Park, H. M.; Au-Yeung, H. Y.; Van de Bittner, G. C.; Ackerman, C. M.; Stahl, A.; Chang, C. J.* Proc. Natl. Acad. Sci. USA 2016, 113, 14219-14224. “A Molecular MoS2 Edge Site Mimic for Catalytic Hydrogen Generation”, Karunadasa, H. I.; Montalvo, E.; Sun, Y.; Majda, M.; Long, J. R.; Chang, C. J.* Science 2012, 335, 698-702. “Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy”, Dodani, S. C.; Domaille, D. W.; Nam, C. I.; Miller, E. W.; Finney, L. A.; Vogt, S.; Chang, C. J.* Proc. Natl. Acad. Sci. USA 2011, 108, 5980-5985. “Aquaporin-3 Mediates Hydrogen Peroxide Uptake to Regulate Downstream Intracellular Signaling”, Miller, E. W.; Dickinson, B. C.; Chang, C. J.* “Proc. Natl. Acad. Sci. USA 2010, 107, 15681-15686. “Molecular Imaging of Hydrogen Peroxide Produced for Cell Signaling”, Miller, E. W.; Tulyathan, O.; Isacoff, E. Y.; Chang, C. J.* Nature Chem. Biol. 2007, 3, 263-267. “A Selective, Cell-Permeable Optical Probe for Hydrogen Peroxide in Living Cells”, Chang, M. C. Y.; Pralle, A.; Isacoff, E. Y.; Chang, C. J.* J. Am. Chem. Soc. 2004, 126, 15392-15393.